Induction of Hsp104 synthesis in Saccharomyces cerevisiae in the stationary growth phase is inhibited by the petite mutation

The elevation of Hsp104 (heat shock protein) content under heat stress plays a key role in the development of thermotolerance in yeast ( Saccharomyces cerevisiae ) cells. Hsp104 synthesis is increased under heat stress and in the stationary growth phase. The loss of mitochondrial DNA (petite mutatio...

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Veröffentlicht in:	Russian journal of genetics 2014-03, Vol.50 (3), p.237-244
Hauptverfasser:	Fedoseeva, I. V., Rikhvanov, E. G., Varakina, N. N., Rusaleva, T. M., Pyatrikas, D. V., Stepanov, A. V., Fedyaeva, A. V.
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Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Genetics of Microorganisms Human Genetics Microbial Genetics and Genomics Saccharomyces cerevisiae
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container_title	Russian journal of genetics
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creator	Fedoseeva, I. V. Rikhvanov, E. G. Varakina, N. N. Rusaleva, T. M. Pyatrikas, D. V. Stepanov, A. V. Fedyaeva, A. V.
description	The elevation of Hsp104 (heat shock protein) content under heat stress plays a key role in the development of thermotolerance in yeast ( Saccharomyces cerevisiae ) cells. Hsp104 synthesis is increased under heat stress and in the stationary growth phase. The loss of mitochondrial DNA (petite mutation) was shown to inhibit the induction of Hsp104 synthesis under heat stress (39°C) and during the transition to the stationary growth phase. Also, the petite mutation suppressed the increase in activity of antioxidant enzymes in the stationary phase, which accompanied by decrease in thermotolerance. At the same time, mutation inhibited production of reactive oxygen species and prevented cell death under heat shock in the logarithmic growth phase. The results of this study suggest that disruption of the mitochondrial functional state suppresses the expression of yeast nuclear genes upon upon entry into the stationary growth phase.
doi_str_mv	10.1134/S102279541403003X
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At the same time, mutation inhibited production of reactive oxygen species and prevented cell death under heat shock in the logarithmic growth phase. 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subjects	Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Genetics of Microorganisms Human Genetics Microbial Genetics and Genomics Saccharomyces cerevisiae
title	Induction of Hsp104 synthesis in Saccharomyces cerevisiae in the stationary growth phase is inhibited by the petite mutation
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