Genomic profiling of histological special types of breast cancer
Histological special types of breast cancer have distinctive morphological features and account for up to 25 % of all invasive breast cancers. We sought to determine whether at the genomic level, histological special types of breast cancer are distinct from grade- and estrogen receptor (ER)-matched...
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| Veröffentlicht in: | Breast cancer research and treatment 2013-11, Vol.142 (2), p.257-269 |
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| creator | Horlings, Hugo M. Weigelt, Britta Anderson, Eric M. Lambros, Maryou B. Mackay, Alan Natrajan, Rachael Ng, Charlotte K. Y. Geyer, Felipe C. van de Vijver, Marc J. Reis-Filho, Jorge S. |
| description | Histological special types of breast cancer have distinctive morphological features and account for up to 25 % of all invasive breast cancers. We sought to determine whether at the genomic level, histological special types of breast cancer are distinct from grade- and estrogen receptor (ER)-matched invasive carcinomas of no special type (IC-NSTs), and to define genes whose expression correlates with gene copy number in histological special types of breast cancer. We characterized 59 breast cancers of ten histological special types using array-based comparative genomic hybridization (aCGH). Hierarchical clustering revealed that the patterns of gene copy number aberrations segregated with ER-status and histological grade, and that samples from each of the breast cancer histological special types preferentially clustered together. We confirmed the patterns of gene copy number aberrations previously reported for lobular, micropapillary, metaplastic, and mucinous carcinomas. On the other hand, metaplastic and medullary carcinomas were found to have genomic profiles similar to those of grade- and ER-matched IC-NSTs. The genomic aberrations observed in invasive carcinomas with osteoclast-like stromal giant cells support its classification as IC-NST variant. Integrative aCGH and gene expression analysis led to the identification of 145 transcripts that were significantly overexpressed when amplified in histological special types of breast cancer. Our results illustrate that together with histological grade and ER-status, histological type is also associated with the patterns and complexity of gene copy number aberrations in breast cancer, with adenoid cystic and mucinous carcinomas being examples of ER-negative and ER-positive breast cancers with distinctive repertoires of gene copy number aberrations. |
| doi_str_mv | 10.1007/s10549-013-2740-6 |
| format | Article |
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Hierarchical clustering revealed that the patterns of gene copy number aberrations segregated with ER-status and histological grade, and that samples from each of the breast cancer histological special types preferentially clustered together. We confirmed the patterns of gene copy number aberrations previously reported for lobular, micropapillary, metaplastic, and mucinous carcinomas. On the other hand, metaplastic and medullary carcinomas were found to have genomic profiles similar to those of grade- and ER-matched IC-NSTs. The genomic aberrations observed in invasive carcinomas with osteoclast-like stromal giant cells support its classification as IC-NST variant. Integrative aCGH and gene expression analysis led to the identification of 145 transcripts that were significantly overexpressed when amplified in histological special types of breast cancer. Our results illustrate that together with histological grade and ER-status, histological type is also associated with the patterns and complexity of gene copy number aberrations in breast cancer, with adenoid cystic and mucinous carcinomas being examples of ER-negative and ER-positive breast cancers with distinctive repertoires of gene copy number aberrations.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-013-2740-6</identifier><identifier>PMID: 24162157</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adenocarcinoma, Mucinous - genetics ; Adenocarcinoma, Mucinous - pathology ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cancer ; Cancer research ; Cancer therapies ; Cluster Analysis ; Cytogenetics ; Estrogen ; Female ; Gene Dosage ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genes ; Genetic aspects ; Genome, Human ; Genomics ; Gynecology. 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Y.</creatorcontrib><creatorcontrib>Geyer, Felipe C.</creatorcontrib><creatorcontrib>van de Vijver, Marc J.</creatorcontrib><creatorcontrib>Reis-Filho, Jorge S.</creatorcontrib><title>Genomic profiling of histological special types of breast cancer</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><addtitle>Breast Cancer Res Treat</addtitle><description>Histological special types of breast cancer have distinctive morphological features and account for up to 25 % of all invasive breast cancers. We sought to determine whether at the genomic level, histological special types of breast cancer are distinct from grade- and estrogen receptor (ER)-matched invasive carcinomas of no special type (IC-NSTs), and to define genes whose expression correlates with gene copy number in histological special types of breast cancer. We characterized 59 breast cancers of ten histological special types using array-based comparative genomic hybridization (aCGH). Hierarchical clustering revealed that the patterns of gene copy number aberrations segregated with ER-status and histological grade, and that samples from each of the breast cancer histological special types preferentially clustered together. We confirmed the patterns of gene copy number aberrations previously reported for lobular, micropapillary, metaplastic, and mucinous carcinomas. On the other hand, metaplastic and medullary carcinomas were found to have genomic profiles similar to those of grade- and ER-matched IC-NSTs. The genomic aberrations observed in invasive carcinomas with osteoclast-like stromal giant cells support its classification as IC-NST variant. Integrative aCGH and gene expression analysis led to the identification of 145 transcripts that were significantly overexpressed when amplified in histological special types of breast cancer. Our results illustrate that together with histological grade and ER-status, histological type is also associated with the patterns and complexity of gene copy number aberrations in breast cancer, with adenoid cystic and mucinous carcinomas being examples of ER-negative and ER-positive breast cancers with distinctive repertoires of gene copy number aberrations.</description><subject>Adenocarcinoma, Mucinous - genetics</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Cluster Analysis</subject><subject>Cytogenetics</subject><subject>Estrogen</subject><subject>Female</subject><subject>Gene Dosage</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genome, Human</subject><subject>Genomics</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Histology</subject><subject>Humans</subject><subject>Hybridization</subject><subject>In Situ Hybridization - methods</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Oncology</subject><subject>Preclinical Study</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Tumors</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk1v1DAQhi0EosvCD-CCIiFQLymeOLbjW6uKlkqVuMDZ8trjXVfZeLGTQ_89Drv0A1FVPsxhnnc8884Q8h7oCVAqv2SgvFU1BVY3sqW1eEEWwCWrZQPyJVlQELIWHRVH5E3ON5RSJal6TY6aFkRTyAU5vcQhboOtdin60IdhXUVfbUIeYx_XwZq-yju0ocTxdod5zq4SmjxW1gwW01vyyps-47tDXJKfF19_nH-rr79fXp2fXdeWMzbWK0c7KZwHx1lnDKwaJcE2Ho11HIRCRMMsk4JRC85TqRx49N47L5STLVuS433d0uivCfOotyFb7HszYJyyBs7arm2LIc-jLVdKcg4z-vEf9CZOaSiD_KEYMK66e2ptetRh8HFMxs5F9RnjjIOUpfElOfkPVZ7DYnAcsPiLjwWfHwg2aPpxk2M_jSEO-TEIe9CmmHNCr3cpbE261UD1fAl6fwm6XIKeL0HPmg-HyabVFt2d4u_qC_DpAJhc1uxTWWfI95xUgoqmKVyz53JJDWtMDyx68vffY7bHrQ</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Horlings, Hugo M.</creator><creator>Weigelt, Britta</creator><creator>Anderson, Eric M.</creator><creator>Lambros, Maryou B.</creator><creator>Mackay, Alan</creator><creator>Natrajan, Rachael</creator><creator>Ng, Charlotte K. 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Y. ; Geyer, Felipe C. ; van de Vijver, Marc J. ; Reis-Filho, Jorge S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-bd0876df1d538aa1b2971c2feacd5169eeea3c37630c1df079d1fefffdf69d743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma, Mucinous - genetics</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>Cluster Analysis</topic><topic>Cytogenetics</topic><topic>Estrogen</topic><topic>Female</topic><topic>Gene Dosage</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genome, Human</topic><topic>Genomics</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Histology</topic><topic>Humans</topic><topic>Hybridization</topic><topic>In Situ Hybridization - methods</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Oncology</topic><topic>Preclinical Study</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horlings, Hugo M.</creatorcontrib><creatorcontrib>Weigelt, Britta</creatorcontrib><creatorcontrib>Anderson, Eric M.</creatorcontrib><creatorcontrib>Lambros, Maryou B.</creatorcontrib><creatorcontrib>Mackay, Alan</creatorcontrib><creatorcontrib>Natrajan, Rachael</creatorcontrib><creatorcontrib>Ng, Charlotte K. Y.</creatorcontrib><creatorcontrib>Geyer, Felipe C.</creatorcontrib><creatorcontrib>van de Vijver, Marc J.</creatorcontrib><creatorcontrib>Reis-Filho, Jorge S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horlings, Hugo M.</au><au>Weigelt, Britta</au><au>Anderson, Eric M.</au><au>Lambros, Maryou B.</au><au>Mackay, Alan</au><au>Natrajan, Rachael</au><au>Ng, Charlotte K. Y.</au><au>Geyer, Felipe C.</au><au>van de Vijver, Marc J.</au><au>Reis-Filho, Jorge S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic profiling of histological special types of breast cancer</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><addtitle>Breast Cancer Res Treat</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>142</volume><issue>2</issue><spage>257</spage><epage>269</epage><pages>257-269</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>Histological special types of breast cancer have distinctive morphological features and account for up to 25 % of all invasive breast cancers. We sought to determine whether at the genomic level, histological special types of breast cancer are distinct from grade- and estrogen receptor (ER)-matched invasive carcinomas of no special type (IC-NSTs), and to define genes whose expression correlates with gene copy number in histological special types of breast cancer. We characterized 59 breast cancers of ten histological special types using array-based comparative genomic hybridization (aCGH). Hierarchical clustering revealed that the patterns of gene copy number aberrations segregated with ER-status and histological grade, and that samples from each of the breast cancer histological special types preferentially clustered together. We confirmed the patterns of gene copy number aberrations previously reported for lobular, micropapillary, metaplastic, and mucinous carcinomas. On the other hand, metaplastic and medullary carcinomas were found to have genomic profiles similar to those of grade- and ER-matched IC-NSTs. The genomic aberrations observed in invasive carcinomas with osteoclast-like stromal giant cells support its classification as IC-NST variant. Integrative aCGH and gene expression analysis led to the identification of 145 transcripts that were significantly overexpressed when amplified in histological special types of breast cancer. Our results illustrate that together with histological grade and ER-status, histological type is also associated with the patterns and complexity of gene copy number aberrations in breast cancer, with adenoid cystic and mucinous carcinomas being examples of ER-negative and ER-positive breast cancers with distinctive repertoires of gene copy number aberrations.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24162157</pmid><doi>10.1007/s10549-013-2740-6</doi><tpages>13</tpages></addata></record> |
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| subjects | Adenocarcinoma, Mucinous - genetics Adenocarcinoma, Mucinous - pathology Biological and medical sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cancer research Cancer therapies Cluster Analysis Cytogenetics Estrogen Female Gene Dosage Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genetic aspects Genome, Human Genomics Gynecology. Andrology. Obstetrics Histology Humans Hybridization In Situ Hybridization - methods Mammary gland diseases Medical sciences Medicine Medicine & Public Health Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oncology Preclinical Study Receptors, Estrogen - metabolism Tumors |
| title | Genomic profiling of histological special types of breast cancer |
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