TCR Affinity Associated with Functional Differences between Dominant and Subdominant SIV Epitope-Specific CD8+ T Cells in Mamu-A01+ Rhesus Monkeys: e1004069

Many of the factors that contribute to CD8+ T cell immunodominance hierarchies during viral infection are known. However, the functional differences that exist between dominant and subdominant epitope-specific CD8+ T cells remain poorly understood. In this study, we characterized the phenotypic and...

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Veröffentlicht in:	PLoS pathogens 2014-04, Vol.10 (4)
Hauptverfasser:	Osuna, Christa E, Gonzalez, Ana Maria, Chang, Hsun-Hsien, Hung, Amy Shi, Ehlinger, Elizabeth, Anasti, Kara, Alam, S Munir, Letvin, Norman L
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytotoxicity Gene expression Genomes HIV Human immunodeficiency virus Infections Lymphocytes Macaca mulatta Peptides Simian immunodeficiency virus Studies Vaccines Viral infections
Online-Zugang:	Volltext
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