Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors

Accumulating data indicate that some microRNAs (miRNAs or miRs) can function as tumor suppressors or oncogenes and as such are important in cancer development. We previously reported that miR-143 and -145 are frequently downregulated in colon adenomas and cancers, acting as tumor suppressors. In thi...

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Veröffentlicht in:	Medical molecular morphology 2013-09, Vol.46 (3), p.166-171
Hauptverfasser:	Kamatani, Akemi, Nakagawa, Yoshihito, Akao, Yukihiro, Maruyama, Naoko, Nagasaka, Mitsuo, Shibata, Tomoyuki, Tahara, Tomomitsu, Hirata, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - metabolism Adult Aged Anatomy Carcinogenesis - genetics Carcinogenesis - metabolism Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Down-Regulation Female Gene Expression Gene Expression Regulation, Neoplastic Genes, APC Humans Male Medicine Medicine & Public Health MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Molecular biology Molecular Medicine Multigene Family Original Paper Pathology Young Adult
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