Small MAF genes variants and chronic myeloid leukemia
Chronic myeloid leukemia (CML) is one of the most frequent hematological neoplasia worldwide. The abnormal accumulation of reactive oxygen species may be an important factor in CML development. The transcription factor NRF2 can regulate the transcription of a battery of antioxidant and detoxificant...
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| Veröffentlicht in: | European journal of haematology 2014-01, Vol.92 (1), p.35-41 |
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| creator | Martínez-Hernández, Angelica Gutierrez-Malacatt, Humberto Carrillo-Sánchez, Karol Saldaña-Alvarez, Yolanda Rojas-Ochoa, Alberto Crespo-Solis, Erick Aguayo-González, Alvaro Rosas-López, Adriana Ayala-Sanchez, Jose Manuel Aquino-Ortega, Xochitl Orozco, Lorena Cordova, Emilio J |
| description | Chronic myeloid leukemia (CML) is one of the most frequent hematological neoplasia worldwide. The abnormal accumulation of reactive oxygen species may be an important factor in CML development. The transcription factor NRF2 can regulate the transcription of a battery of antioxidant and detoxificant genes after heterodimerizing with small‐Maf proteins. Although the participation of NRF2 in the development of chronic degenerative diseases has been thoroughly studied, the role of small‐Maf genes has not been documented. We have identified polymorphisms in the three MAF genes (F, G and K) and assessed their association with CML. Over 266 subjects with CML and 399 unrelated healthy donors have been studied. After sequencing each MAF gene by Sanger technology, we found 17 variants in MAFF gene, eight in MAFG and seven in MAFK. In the case‐control study, the homozygote genotype CC for the rs9610915 SNP of MAFF was significantly associated with CML. The frequency of the ACC haplotype from MAFK was significantly lower than controls. After stratification by gender, the ACC and GTG haplotypes were associated only with males with CML. These novel data suggest an association between MAFF and MAFG and the development of CML. |
| doi_str_mv | 10.1111/ejh.12211 |
| format | Article |
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The abnormal accumulation of reactive oxygen species may be an important factor in CML development. The transcription factor NRF2 can regulate the transcription of a battery of antioxidant and detoxificant genes after heterodimerizing with small‐Maf proteins. Although the participation of NRF2 in the development of chronic degenerative diseases has been thoroughly studied, the role of small‐Maf genes has not been documented. We have identified polymorphisms in the three MAF genes (F, G and K) and assessed their association with CML. Over 266 subjects with CML and 399 unrelated healthy donors have been studied. After sequencing each MAF gene by Sanger technology, we found 17 variants in MAFF gene, eight in MAFG and seven in MAFK. In the case‐control study, the homozygote genotype CC for the rs9610915 SNP of MAFF was significantly associated with CML. The frequency of the ACC haplotype from MAFK was significantly lower than controls. After stratification by gender, the ACC and GTG haplotypes were associated only with males with CML. These novel data suggest an association between MAFF and MAFG and the development of CML.</description><identifier>ISSN: 0902-4441</identifier><identifier>EISSN: 1600-0609</identifier><identifier>DOI: 10.1111/ejh.12211</identifier><identifier>PMID: 24118457</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Alleles ; Case-Control Studies ; Computational Biology ; Female ; Gene Frequency ; Genetic Variation ; Genotype ; Haplotypes ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics ; MafF Transcription Factor - genetics ; MAFG ; MAFK ; MafK Transcription Factor - genetics ; Male ; Middle Aged ; Nuclear Proteins - genetics ; Odds Ratio ; oxidative stress ; Polymorphism, Single Nucleotide ; polymorphisms ; Proto-Oncogene Proteins c-maf - genetics ; re-sequencing ; Sex Factors</subject><ispartof>European journal of haematology, 2014-01, Vol.92 (1), p.35-41</ispartof><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4621-1ae934c132fb2ea8994094f6b11b042d8a3fe1dae958813ee2e8501c52eb3b0f3</citedby><cites>FETCH-LOGICAL-c4621-1ae934c132fb2ea8994094f6b11b042d8a3fe1dae958813ee2e8501c52eb3b0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejh.12211$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejh.12211$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24118457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martínez-Hernández, Angelica</creatorcontrib><creatorcontrib>Gutierrez-Malacatt, Humberto</creatorcontrib><creatorcontrib>Carrillo-Sánchez, Karol</creatorcontrib><creatorcontrib>Saldaña-Alvarez, Yolanda</creatorcontrib><creatorcontrib>Rojas-Ochoa, Alberto</creatorcontrib><creatorcontrib>Crespo-Solis, Erick</creatorcontrib><creatorcontrib>Aguayo-González, Alvaro</creatorcontrib><creatorcontrib>Rosas-López, Adriana</creatorcontrib><creatorcontrib>Ayala-Sanchez, Jose Manuel</creatorcontrib><creatorcontrib>Aquino-Ortega, Xochitl</creatorcontrib><creatorcontrib>Orozco, Lorena</creatorcontrib><creatorcontrib>Cordova, Emilio J</creatorcontrib><title>Small MAF genes variants and chronic myeloid leukemia</title><title>European journal of haematology</title><addtitle>Eur J Haematol</addtitle><description>Chronic myeloid leukemia (CML) is one of the most frequent hematological neoplasia worldwide. The abnormal accumulation of reactive oxygen species may be an important factor in CML development. The transcription factor NRF2 can regulate the transcription of a battery of antioxidant and detoxificant genes after heterodimerizing with small‐Maf proteins. Although the participation of NRF2 in the development of chronic degenerative diseases has been thoroughly studied, the role of small‐Maf genes has not been documented. We have identified polymorphisms in the three MAF genes (F, G and K) and assessed their association with CML. Over 266 subjects with CML and 399 unrelated healthy donors have been studied. After sequencing each MAF gene by Sanger technology, we found 17 variants in MAFF gene, eight in MAFG and seven in MAFK. In the case‐control study, the homozygote genotype CC for the rs9610915 SNP of MAFF was significantly associated with CML. The frequency of the ACC haplotype from MAFK was significantly lower than controls. After stratification by gender, the ACC and GTG haplotypes were associated only with males with CML. These novel data suggest an association between MAFF and MAFG and the development of CML.</description><subject>Adult</subject><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Computational Biology</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics</subject><subject>MafF Transcription Factor - genetics</subject><subject>MAFG</subject><subject>MAFK</subject><subject>MafK Transcription Factor - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nuclear Proteins - genetics</subject><subject>Odds Ratio</subject><subject>oxidative stress</subject><subject>Polymorphism, Single Nucleotide</subject><subject>polymorphisms</subject><subject>Proto-Oncogene Proteins c-maf - genetics</subject><subject>re-sequencing</subject><subject>Sex Factors</subject><issn>0902-4441</issn><issn>1600-0609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOw0AQRVcIBOFR8APIJRQOM7vrx5ZRlAAmgBAgytXaHoMTP4I3BvL3GAx0iGmmOfcUh7FDhCF2d0rz5yFyjrjBBugDuOCD2mQDUMBdKSXusF1r5wDAFQbbbIdLxFB6wYB5d6UpCudqNHWeqCLrvJomN9XKOqZKneS5qas8cco1FXWeOgW1Cypzs8-2MlNYOvj-e-xhOrkfn7uzm7OL8WjmJtLn6KIhJWSCgmcxJxMqJUHJzI8RY5A8DY3ICNOO8sIQBRGn0ANMPE6xiCETe-y49y6b-qUlu9JlbhMqClNR3VqNnpChBAT8H5WKB10BoTr0pEeTpra2oUwvm7w0zVoj6M-guguqv4J27NG3to1LSn_Jn4IdcNoDb3lB679NehKd_yjdfpHbFb3_Lkyz0H4gAk8_Xp_p6FJG00iE-lZ8AM9di6o</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Martínez-Hernández, Angelica</creator><creator>Gutierrez-Malacatt, Humberto</creator><creator>Carrillo-Sánchez, Karol</creator><creator>Saldaña-Alvarez, Yolanda</creator><creator>Rojas-Ochoa, Alberto</creator><creator>Crespo-Solis, Erick</creator><creator>Aguayo-González, Alvaro</creator><creator>Rosas-López, Adriana</creator><creator>Ayala-Sanchez, Jose Manuel</creator><creator>Aquino-Ortega, Xochitl</creator><creator>Orozco, Lorena</creator><creator>Cordova, Emilio J</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201401</creationdate><title>Small MAF genes variants and chronic myeloid leukemia</title><author>Martínez-Hernández, Angelica ; 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The abnormal accumulation of reactive oxygen species may be an important factor in CML development. The transcription factor NRF2 can regulate the transcription of a battery of antioxidant and detoxificant genes after heterodimerizing with small‐Maf proteins. Although the participation of NRF2 in the development of chronic degenerative diseases has been thoroughly studied, the role of small‐Maf genes has not been documented. We have identified polymorphisms in the three MAF genes (F, G and K) and assessed their association with CML. Over 266 subjects with CML and 399 unrelated healthy donors have been studied. After sequencing each MAF gene by Sanger technology, we found 17 variants in MAFF gene, eight in MAFG and seven in MAFK. In the case‐control study, the homozygote genotype CC for the rs9610915 SNP of MAFF was significantly associated with CML. The frequency of the ACC haplotype from MAFK was significantly lower than controls. After stratification by gender, the ACC and GTG haplotypes were associated only with males with CML. These novel data suggest an association between MAFF and MAFG and the development of CML.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24118457</pmid><doi>10.1111/ejh.12211</doi><tpages>7</tpages></addata></record> |
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| ispartof | European journal of haematology, 2014-01, Vol.92 (1), p.35-41 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Alleles Case-Control Studies Computational Biology Female Gene Frequency Genetic Variation Genotype Haplotypes Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics MafF Transcription Factor - genetics MAFG MAFK MafK Transcription Factor - genetics Male Middle Aged Nuclear Proteins - genetics Odds Ratio oxidative stress Polymorphism, Single Nucleotide polymorphisms Proto-Oncogene Proteins c-maf - genetics re-sequencing Sex Factors |
| title | Small MAF genes variants and chronic myeloid leukemia |
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