Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis

Objective Proliferating pannus is in many aspects similar to placental tissue. Both fibroblast‐rich tissues have high vascularity, and tissue from patients with rheumatoid arthritis (RA) and patients with osteoarthritis (OA) demonstrates conversion of androgenic prehormones to downstream estrogens....

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2012-06, Vol.64 (6), p.1799-1808
Hauptverfasser:	Lowin, Torsten, Weidler, Claudia, Jenei-Lanzl, Zsuzsa, Capellino, Silvia, Baerwald, Christoph G. O., Buttgereit, Frank, Straub, Rainer H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aromatase - metabolism Arthritis, Rheumatoid - metabolism Biological and medical sciences Dehydroepiandrosterone - metabolism Dehydroepiandrosterone Sulfate - metabolism Diseases of the osteoarticular system Female Humans Inflammatory joint diseases Knee Joint - metabolism Macrophages - metabolism Male Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Neovascularization, Pathologic - metabolism Osteoarthritis Osteoarthritis, Knee - metabolism Placenta Placenta Growth Factor Pregnancy Proteins - metabolism Rheumatoid arthritis Studies Synovial Fluid - metabolism Synovial Membrane - metabolism Vascular Endothelial Growth Factor A - metabolism
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