Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis
Objective Proliferating pannus is in many aspects similar to placental tissue. Both fibroblast‐rich tissues have high vascularity, and tissue from patients with rheumatoid arthritis (RA) and patients with osteoarthritis (OA) demonstrates conversion of androgenic prehormones to downstream estrogens....
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| Veröffentlicht in: | Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2012-06, Vol.64 (6), p.1799-1808 |
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| creator | Lowin, Torsten Weidler, Claudia Jenei-Lanzl, Zsuzsa Capellino, Silvia Baerwald, Christoph G. O. Buttgereit, Frank Straub, Rainer H. |
| description | Objective
Proliferating pannus is in many aspects similar to placental tissue. Both fibroblast‐rich tissues have high vascularity, and tissue from patients with rheumatoid arthritis (RA) and patients with osteoarthritis (OA) demonstrates conversion of androgenic prehormones to downstream estrogens. We undertook this study to investigate similarities between proliferating pannus and placental tissue by focusing on angiogenic placenta growth factor 1 (PlGF‐1) in patients with OA and patients with RA.
Methods
We used immunohistochemistry to study the presence of PlGF‐1, its synovial distribution, and the PlGF‐1–expressing synovial cell type. The relationship between PlGF‐1 and conversion of the biologically inactive placental prehormone dehydroepiandrosterone sulfate (DHEAS) to the biologically active dehydroepiandrosterone (DHEA) was investigated in mixed synovial cells. The effects of DHEA on PlGF‐1 expression were studied by intracellular fluorescence‐activated cell sorting analysis.
Results
PlGF‐1–positive cells were detected in the lining and sublining areas in patients with RA and patients with OA, and cellular density was similar. Double staining revealed that PlGF‐1–positive cells were macrophages. In RA and OA, the density of PlGF‐1–positive cells correlated positively with the density of macrophages and the density of type IV collagen–positive vessels. The supernatant concentration of 3H‐DHEA after conversion from 3H‐DHEAS and the density of aromatase‐positive cells were positively correlated with the density of PlGF‐1–positive cells only in OA. Low DHEA concentrations (≤10−9M) had stimulatory effects on PlGF‐1 when compared to serum concentrations (10−8M to 10−7M) in the monocytic cell line THP‐1 and in primary mixed synovial cells.
Conclusion
PlGF‐1 functions similarly in inflamed synovium and in the placenta. It is related to vessel formation and, in OA patients, to androgen/estrogen conversion. Evolutionarily conserved functions of PlGF‐1 for placental phenomena are obviously also present in synovial inflammation. |
| doi_str_mv | 10.1002/art.34338 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1534839710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1534839710</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4548-31aaec82889e54424964cc4840f6c3b50bc61ede80fa5b95f3169ea6c4c4ec153</originalsourceid><addsrcrecordid>eNqFkl1rFDEUhgdRbK1e-AckIIKC0-ZrZjKXpWgVSsW1fuBNOJs546bOTsYk0-36g_0dZj-6olC8CiHP-54355wse8zoIaOUH4GPh0IKoe5k-6zgdU6ZYHezfUqpzEVRs73sQQiX6cpFIe5ne5yzispC7Ge_JthBtK4PMzuQKcYFYk-GDgz2Ecg37xZxRlow0XnCCPQNuYJgxg68_bkWviQNzpaNdzjY9OxdiOhdjySMXQsRSXS3Ecb1V-jD2iTZg3dziBCQ4PXgMaweiE1pUp2UJpCFTVn8DMeEOdskQZx5G21Y5_obWxVxO-Bhdq-FLuCj7XmQfXz96uLkTX727vTtyfFZbmQhVS4YABrFlaqxkJLLupTGSCVpWxoxLejUlAwbVLSFYloXrWBljVAaaSQaVoiD7PnGd_Dux4gh6rkNBrsOenRj0AmRStQVo_9HKVOirLgqE_r0H_TSjb5PH0mGrGKsklwl6sWGMqnDwWOrB2_n4JfJSq_2RKd26PWeJPbJ1nGczrHZkTeLkYBnWyBNG7rWQ29s-MOVlFNerbijDbewHS5vr6iPJxc3pfONwqYJXe8U4L_rshJVoT-fn-ovk8n5108fqH4vfgMe7Ot4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1517117428</pqid></control><display><type>article</type><title>Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lowin, Torsten ; Weidler, Claudia ; Jenei-Lanzl, Zsuzsa ; Capellino, Silvia ; Baerwald, Christoph G. O. ; Buttgereit, Frank ; Straub, Rainer H.</creator><creatorcontrib>Lowin, Torsten ; Weidler, Claudia ; Jenei-Lanzl, Zsuzsa ; Capellino, Silvia ; Baerwald, Christoph G. O. ; Buttgereit, Frank ; Straub, Rainer H.</creatorcontrib><description>Objective
Proliferating pannus is in many aspects similar to placental tissue. Both fibroblast‐rich tissues have high vascularity, and tissue from patients with rheumatoid arthritis (RA) and patients with osteoarthritis (OA) demonstrates conversion of androgenic prehormones to downstream estrogens. We undertook this study to investigate similarities between proliferating pannus and placental tissue by focusing on angiogenic placenta growth factor 1 (PlGF‐1) in patients with OA and patients with RA.
Methods
We used immunohistochemistry to study the presence of PlGF‐1, its synovial distribution, and the PlGF‐1–expressing synovial cell type. The relationship between PlGF‐1 and conversion of the biologically inactive placental prehormone dehydroepiandrosterone sulfate (DHEAS) to the biologically active dehydroepiandrosterone (DHEA) was investigated in mixed synovial cells. The effects of DHEA on PlGF‐1 expression were studied by intracellular fluorescence‐activated cell sorting analysis.
Results
PlGF‐1–positive cells were detected in the lining and sublining areas in patients with RA and patients with OA, and cellular density was similar. Double staining revealed that PlGF‐1–positive cells were macrophages. In RA and OA, the density of PlGF‐1–positive cells correlated positively with the density of macrophages and the density of type IV collagen–positive vessels. The supernatant concentration of 3H‐DHEA after conversion from 3H‐DHEAS and the density of aromatase‐positive cells were positively correlated with the density of PlGF‐1–positive cells only in OA. Low DHEA concentrations (≤10−9M) had stimulatory effects on PlGF‐1 when compared to serum concentrations (10−8M to 10−7M) in the monocytic cell line THP‐1 and in primary mixed synovial cells.
Conclusion
PlGF‐1 functions similarly in inflamed synovium and in the placenta. It is related to vessel formation and, in OA patients, to androgen/estrogen conversion. Evolutionarily conserved functions of PlGF‐1 for placental phenomena are obviously also present in synovial inflammation.</description><identifier>ISSN: 0004-3591</identifier><identifier>ISSN: 2326-5191</identifier><identifier>EISSN: 1529-0131</identifier><identifier>EISSN: 2326-5205</identifier><identifier>DOI: 10.1002/art.34338</identifier><identifier>PMID: 22170453</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aromatase - metabolism ; Arthritis, Rheumatoid - metabolism ; Biological and medical sciences ; Dehydroepiandrosterone - metabolism ; Dehydroepiandrosterone Sulfate - metabolism ; Diseases of the osteoarticular system ; Female ; Humans ; Inflammatory joint diseases ; Knee Joint - metabolism ; Macrophages - metabolism ; Male ; Medical sciences ; Middle Aged ; Miscellaneous. Osteoarticular involvement in other diseases ; Neovascularization, Pathologic - metabolism ; Osteoarthritis ; Osteoarthritis, Knee - metabolism ; Placenta ; Placenta Growth Factor ; Pregnancy Proteins - metabolism ; Rheumatoid arthritis ; Studies ; Synovial Fluid - metabolism ; Synovial Membrane - metabolism ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Arthritis & rheumatology (Hoboken, N.J.), 2012-06, Vol.64 (6), p.1799-1808</ispartof><rights>Copyright © 2012 by the American College of Rheumatology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 by the American College of Rheumatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4548-31aaec82889e54424964cc4840f6c3b50bc61ede80fa5b95f3169ea6c4c4ec153</citedby><cites>FETCH-LOGICAL-c4548-31aaec82889e54424964cc4840f6c3b50bc61ede80fa5b95f3169ea6c4c4ec153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.34338$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.34338$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26020273$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22170453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lowin, Torsten</creatorcontrib><creatorcontrib>Weidler, Claudia</creatorcontrib><creatorcontrib>Jenei-Lanzl, Zsuzsa</creatorcontrib><creatorcontrib>Capellino, Silvia</creatorcontrib><creatorcontrib>Baerwald, Christoph G. O.</creatorcontrib><creatorcontrib>Buttgereit, Frank</creatorcontrib><creatorcontrib>Straub, Rainer H.</creatorcontrib><title>Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis</title><title>Arthritis & rheumatology (Hoboken, N.J.)</title><addtitle>Arthritis & Rheumatism</addtitle><description>Objective
Proliferating pannus is in many aspects similar to placental tissue. Both fibroblast‐rich tissues have high vascularity, and tissue from patients with rheumatoid arthritis (RA) and patients with osteoarthritis (OA) demonstrates conversion of androgenic prehormones to downstream estrogens. We undertook this study to investigate similarities between proliferating pannus and placental tissue by focusing on angiogenic placenta growth factor 1 (PlGF‐1) in patients with OA and patients with RA.
Methods
We used immunohistochemistry to study the presence of PlGF‐1, its synovial distribution, and the PlGF‐1–expressing synovial cell type. The relationship between PlGF‐1 and conversion of the biologically inactive placental prehormone dehydroepiandrosterone sulfate (DHEAS) to the biologically active dehydroepiandrosterone (DHEA) was investigated in mixed synovial cells. The effects of DHEA on PlGF‐1 expression were studied by intracellular fluorescence‐activated cell sorting analysis.
Results
PlGF‐1–positive cells were detected in the lining and sublining areas in patients with RA and patients with OA, and cellular density was similar. Double staining revealed that PlGF‐1–positive cells were macrophages. In RA and OA, the density of PlGF‐1–positive cells correlated positively with the density of macrophages and the density of type IV collagen–positive vessels. The supernatant concentration of 3H‐DHEA after conversion from 3H‐DHEAS and the density of aromatase‐positive cells were positively correlated with the density of PlGF‐1–positive cells only in OA. Low DHEA concentrations (≤10−9M) had stimulatory effects on PlGF‐1 when compared to serum concentrations (10−8M to 10−7M) in the monocytic cell line THP‐1 and in primary mixed synovial cells.
Conclusion
PlGF‐1 functions similarly in inflamed synovium and in the placenta. It is related to vessel formation and, in OA patients, to androgen/estrogen conversion. Evolutionarily conserved functions of PlGF‐1 for placental phenomena are obviously also present in synovial inflammation.</description><subject>Aged</subject><subject>Aromatase - metabolism</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Dehydroepiandrosterone - metabolism</subject><subject>Dehydroepiandrosterone Sulfate - metabolism</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Knee Joint - metabolism</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - metabolism</subject><subject>Placenta</subject><subject>Placenta Growth Factor</subject><subject>Pregnancy Proteins - metabolism</subject><subject>Rheumatoid arthritis</subject><subject>Studies</subject><subject>Synovial Fluid - metabolism</subject><subject>Synovial Membrane - metabolism</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0004-3591</issn><issn>2326-5191</issn><issn>1529-0131</issn><issn>2326-5205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl1rFDEUhgdRbK1e-AckIIKC0-ZrZjKXpWgVSsW1fuBNOJs546bOTsYk0-36g_0dZj-6olC8CiHP-54355wse8zoIaOUH4GPh0IKoe5k-6zgdU6ZYHezfUqpzEVRs73sQQiX6cpFIe5ne5yzispC7Ge_JthBtK4PMzuQKcYFYk-GDgz2Ecg37xZxRlow0XnCCPQNuYJgxg68_bkWviQNzpaNdzjY9OxdiOhdjySMXQsRSXS3Ecb1V-jD2iTZg3dziBCQ4PXgMaweiE1pUp2UJpCFTVn8DMeEOdskQZx5G21Y5_obWxVxO-Bhdq-FLuCj7XmQfXz96uLkTX727vTtyfFZbmQhVS4YABrFlaqxkJLLupTGSCVpWxoxLejUlAwbVLSFYloXrWBljVAaaSQaVoiD7PnGd_Dux4gh6rkNBrsOenRj0AmRStQVo_9HKVOirLgqE_r0H_TSjb5PH0mGrGKsklwl6sWGMqnDwWOrB2_n4JfJSq_2RKd26PWeJPbJ1nGczrHZkTeLkYBnWyBNG7rWQ29s-MOVlFNerbijDbewHS5vr6iPJxc3pfONwqYJXe8U4L_rshJVoT-fn-ovk8n5108fqH4vfgMe7Ot4</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Lowin, Torsten</creator><creator>Weidler, Claudia</creator><creator>Jenei-Lanzl, Zsuzsa</creator><creator>Capellino, Silvia</creator><creator>Baerwald, Christoph G. O.</creator><creator>Buttgereit, Frank</creator><creator>Straub, Rainer H.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis</title><author>Lowin, Torsten ; Weidler, Claudia ; Jenei-Lanzl, Zsuzsa ; Capellino, Silvia ; Baerwald, Christoph G. O. ; Buttgereit, Frank ; Straub, Rainer H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4548-31aaec82889e54424964cc4840f6c3b50bc61ede80fa5b95f3169ea6c4c4ec153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aromatase - metabolism</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Dehydroepiandrosterone - metabolism</topic><topic>Dehydroepiandrosterone Sulfate - metabolism</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Knee Joint - metabolism</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Knee - metabolism</topic><topic>Placenta</topic><topic>Placenta Growth Factor</topic><topic>Pregnancy Proteins - metabolism</topic><topic>Rheumatoid arthritis</topic><topic>Studies</topic><topic>Synovial Fluid - metabolism</topic><topic>Synovial Membrane - metabolism</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lowin, Torsten</creatorcontrib><creatorcontrib>Weidler, Claudia</creatorcontrib><creatorcontrib>Jenei-Lanzl, Zsuzsa</creatorcontrib><creatorcontrib>Capellino, Silvia</creatorcontrib><creatorcontrib>Baerwald, Christoph G. O.</creatorcontrib><creatorcontrib>Buttgereit, Frank</creatorcontrib><creatorcontrib>Straub, Rainer H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lowin, Torsten</au><au>Weidler, Claudia</au><au>Jenei-Lanzl, Zsuzsa</au><au>Capellino, Silvia</au><au>Baerwald, Christoph G. O.</au><au>Buttgereit, Frank</au><au>Straub, Rainer H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis</atitle><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle><addtitle>Arthritis & Rheumatism</addtitle><date>2012-06</date><risdate>2012</risdate><volume>64</volume><issue>6</issue><spage>1799</spage><epage>1808</epage><pages>1799-1808</pages><issn>0004-3591</issn><issn>2326-5191</issn><eissn>1529-0131</eissn><eissn>2326-5205</eissn><coden>ARHEAW</coden><abstract>Objective
Proliferating pannus is in many aspects similar to placental tissue. Both fibroblast‐rich tissues have high vascularity, and tissue from patients with rheumatoid arthritis (RA) and patients with osteoarthritis (OA) demonstrates conversion of androgenic prehormones to downstream estrogens. We undertook this study to investigate similarities between proliferating pannus and placental tissue by focusing on angiogenic placenta growth factor 1 (PlGF‐1) in patients with OA and patients with RA.
Methods
We used immunohistochemistry to study the presence of PlGF‐1, its synovial distribution, and the PlGF‐1–expressing synovial cell type. The relationship between PlGF‐1 and conversion of the biologically inactive placental prehormone dehydroepiandrosterone sulfate (DHEAS) to the biologically active dehydroepiandrosterone (DHEA) was investigated in mixed synovial cells. The effects of DHEA on PlGF‐1 expression were studied by intracellular fluorescence‐activated cell sorting analysis.
Results
PlGF‐1–positive cells were detected in the lining and sublining areas in patients with RA and patients with OA, and cellular density was similar. Double staining revealed that PlGF‐1–positive cells were macrophages. In RA and OA, the density of PlGF‐1–positive cells correlated positively with the density of macrophages and the density of type IV collagen–positive vessels. The supernatant concentration of 3H‐DHEA after conversion from 3H‐DHEAS and the density of aromatase‐positive cells were positively correlated with the density of PlGF‐1–positive cells only in OA. Low DHEA concentrations (≤10−9M) had stimulatory effects on PlGF‐1 when compared to serum concentrations (10−8M to 10−7M) in the monocytic cell line THP‐1 and in primary mixed synovial cells.
Conclusion
PlGF‐1 functions similarly in inflamed synovium and in the placenta. It is related to vessel formation and, in OA patients, to androgen/estrogen conversion. Evolutionarily conserved functions of PlGF‐1 for placental phenomena are obviously also present in synovial inflammation.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22170453</pmid><doi>10.1002/art.34338</doi><tpages>10</tpages></addata></record> |
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| ispartof | Arthritis & rheumatology (Hoboken, N.J.), 2012-06, Vol.64 (6), p.1799-1808 |
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| subjects | Aged Aromatase - metabolism Arthritis, Rheumatoid - metabolism Biological and medical sciences Dehydroepiandrosterone - metabolism Dehydroepiandrosterone Sulfate - metabolism Diseases of the osteoarticular system Female Humans Inflammatory joint diseases Knee Joint - metabolism Macrophages - metabolism Male Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Neovascularization, Pathologic - metabolism Osteoarthritis Osteoarthritis, Knee - metabolism Placenta Placenta Growth Factor Pregnancy Proteins - metabolism Rheumatoid arthritis Studies Synovial Fluid - metabolism Synovial Membrane - metabolism Vascular Endothelial Growth Factor A - metabolism |
| title | Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis |
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