A Quantitative High-Resolution Genetic Profile Rapidly Identifies Sequence Determinants of Hepatitis C Viral Fitness and Drug Sensitivity: e1004064

Widely used chemical genetic screens have greatly facilitated the identification of many antiviral agents. However, the regions of interaction and inhibitory mechanisms of many therapeutic candidates have yet to be elucidated. Previous chemical screens identified Daclatasvir (BMS-790052) as a potent...

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Veröffentlicht in:	PLoS pathogens 2014-04, Vol.10 (4)
Hauptverfasser:	Qi, Hangfei, Olson, C Anders, Wu, Nicholas C, Ke, Ruian, Loverdo, Claude, Chu, Virginia, Truong, Shawna, Remenyi, Roland, Chen, Zugen, Du, Yushen, Su, Sheng-Yao, Al-Mawsawi, Laith Q, Wu, Ting-Ting, Chen, Shu-Hua, Lin, Chung-Yen, Zhong, Weidong, Lloyd-Smith, James O, Sun, Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antiviral agents Biomedical research Cancer Cancer therapies Drug resistance Hepatitis Hepatitis C virus Infections Libraries Mathematical models Mutation Pharmaceuticals Probability Proteins Technological change
Online-Zugang:	Volltext
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