Effect of micronutrient deficiency on QuantiFERON-TB Gold In-Tube test and tuberculin skin test in diagnosis of childhood intrathoracic tuberculosis
Background/Objectives: Data on performance of QuantiFERON-TB Gold In-Tube test (QFT) and tuberculin skin test (TST) in children with active tuberculosis from high burden countries in the context of micronutrient deficiency are scarce. The objective of this study was to evaluate the effect of micronu...
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| Veröffentlicht in: | European journal of clinical nutrition 2014-01, Vol.68 (1), p.38-42 |
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| creator | Mukherjee, A Saini, S Kabra, S K Gupta, N Singh, V Singh, S Bhatnagar, S Saini, D Grewal, H M S Lodha, R |
| description | Background/Objectives:
Data on performance of QuantiFERON-TB Gold In-Tube test (QFT) and tuberculin skin test (TST) in children with active tuberculosis from high burden countries in the context of micronutrient deficiency are scarce. The objective of this study was to evaluate the effect of micronutrient deficiency on the performance of TST and QFT in children with intrathoracic tuberculosis.
subjects/Methods:
Children with probable intrathoracic tuberculosis underwent TST, QFT, gastric lavages and induced sputum examination for AFB (Acid-Fast Bacilli) smear and culture. Zinc, copper, ferritin and vitamin D were measured on stored serum samples. The study used cross-sectional data at initiation of anti-tubercular therapy.
Results:
Three hundred and sixty-two children (median age 115.5 months (interquartile range: 73, 144), 200 (55.3%) girls) were enrolled in the study. Microbiological confirmation of tuberculosis could be obtained in 128 patients. TST and QFT were positive in 337 (93%) and 297 (82%) children, respectively. Performance of both the tests was unaffected by weight-for-age and height-for-age ‘
z
-scores’ or by serum copper levels. TST was not affected by serum zinc and ferritin levels. Children with negative QFT results had lower mean serum zinc level (
P
=0.01) and higher ferritin levels (
P
=0.007) as compared to those with positive test. Higher proportion of children with positive TST were vitamin D deficient/insufficient (
P
=0.003).
Conclusion:
Micronutrient status, especially serum levels of zinc, may influence the performance of QFT in children with intrathoracic tuberculosis. Considering the high prevalence of zinc deficiency in developing countries, QFT should be used cautiously for diagnosing tuberculosis. |
| doi_str_mv | 10.1038/ejcn.2013.216 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1534836865</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A357967960</galeid><sourcerecordid>A357967960</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-cf5eeb66c50789510e1d4cd30cecf32b94d8252088641b74cfeab1b76f9409153</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhi0EotvCkSuyhIR6yWInjhMfS7UtlSoq0HK2HH_sesnaxXYO_R_8YCZsKQVxQLI8Y83j8cz4RegVJUtKmv6d3emwrAltljXlT9CCso5XLWfkKVoQ0bKqIaQ7Qsc57wiBYFc_R0c1o1wwThfo-8o5qwuODu-9TjFMJXkbCjbWeQ2evsMx4E-TCsVfrD7ffKzW7_FlHA2-CtV6GiwuNhesgsEFTklPow84f4XtZwCs8WoTYvZ5fkVv_Wi2MRqIlKTKNialvX64PHMv0DOnxmxf3tsT9OVitT7_UF3fXF6dn11XmglaKu1aawfOdUu6XrSUWGqYNg3RVrumHgQzfd3WpO85o0PHtLNqAIc7wYigbXOCTg95b1P8NkG1cu-ztuOogo1TloCwvuE9_w-UCdJRmHsP6Ju_0F2cUoBGgOpaSoXgzW9qo0YrfXARpqHnpPKsaTvBYRGg3j6itlaNZZvjOBUfQ_4TrA4g_GHOyTp5m_xepTtJiZyFImehyFkoEoQC_Ov7Iqdhb80D_UsZACwPQIZQ2Nj0qIt_ZvwBjbDHwg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1475119963</pqid></control><display><type>article</type><title>Effect of micronutrient deficiency on QuantiFERON-TB Gold In-Tube test and tuberculin skin test in diagnosis of childhood intrathoracic tuberculosis</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Mukherjee, A ; Saini, S ; Kabra, S K ; Gupta, N ; Singh, V ; Singh, S ; Bhatnagar, S ; Saini, D ; Grewal, H M S ; Lodha, R</creator><creatorcontrib>Mukherjee, A ; Saini, S ; Kabra, S K ; Gupta, N ; Singh, V ; Singh, S ; Bhatnagar, S ; Saini, D ; Grewal, H M S ; Lodha, R ; Delhi TB Study group</creatorcontrib><description>Background/Objectives:
Data on performance of QuantiFERON-TB Gold In-Tube test (QFT) and tuberculin skin test (TST) in children with active tuberculosis from high burden countries in the context of micronutrient deficiency are scarce. The objective of this study was to evaluate the effect of micronutrient deficiency on the performance of TST and QFT in children with intrathoracic tuberculosis.
subjects/Methods:
Children with probable intrathoracic tuberculosis underwent TST, QFT, gastric lavages and induced sputum examination for AFB (Acid-Fast Bacilli) smear and culture. Zinc, copper, ferritin and vitamin D were measured on stored serum samples. The study used cross-sectional data at initiation of anti-tubercular therapy.
Results:
Three hundred and sixty-two children (median age 115.5 months (interquartile range: 73, 144), 200 (55.3%) girls) were enrolled in the study. Microbiological confirmation of tuberculosis could be obtained in 128 patients. TST and QFT were positive in 337 (93%) and 297 (82%) children, respectively. Performance of both the tests was unaffected by weight-for-age and height-for-age ‘
z
-scores’ or by serum copper levels. TST was not affected by serum zinc and ferritin levels. Children with negative QFT results had lower mean serum zinc level (
P
=0.01) and higher ferritin levels (
P
=0.007) as compared to those with positive test. Higher proportion of children with positive TST were vitamin D deficient/insufficient (
P
=0.003).
Conclusion:
Micronutrient status, especially serum levels of zinc, may influence the performance of QFT in children with intrathoracic tuberculosis. Considering the high prevalence of zinc deficiency in developing countries, QFT should be used cautiously for diagnosing tuberculosis.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2013.216</identifier><identifier>PMID: 24169461</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/1702/295 ; 692/699/255/1856 ; 692/700/139 ; 692/700/1720 ; Adolescent ; Antitubercular Agents - therapeutic use ; Child ; Child, Preschool ; Children ; Childrens health ; Clinical Nutrition ; Copper ; Copper - blood ; Cross-Sectional Studies ; Developing countries ; Diagnosis ; Diagnostic tests ; Diseases ; Double-Blind Method ; Epidemiology ; Female ; Ferritins - blood ; Gold ; Humans ; India ; Infant ; Internal Medicine ; LDCs ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Metabolic Diseases ; Methods ; Micronutrients - administration & dosage ; Micronutrients - deficiency ; Mycobacterium ; Nutrition ; original-article ; Prevalence ; Public Health ; Randomized Controlled Trials as Topic ; Skin tests ; Tuberculin Test - methods ; Tuberculosis ; Tuberculosis - diagnosis ; Tuberculosis - drug therapy ; Vitamin D ; Vitamin D - blood ; Zinc ; Zinc - blood</subject><ispartof>European journal of clinical nutrition, 2014-01, Vol.68 (1), p.38-42</ispartof><rights>Macmillan Publishers Limited 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-cf5eeb66c50789510e1d4cd30cecf32b94d8252088641b74cfeab1b76f9409153</citedby><cites>FETCH-LOGICAL-c491t-cf5eeb66c50789510e1d4cd30cecf32b94d8252088641b74cfeab1b76f9409153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ejcn.2013.216$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ejcn.2013.216$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24169461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mukherjee, A</creatorcontrib><creatorcontrib>Saini, S</creatorcontrib><creatorcontrib>Kabra, S K</creatorcontrib><creatorcontrib>Gupta, N</creatorcontrib><creatorcontrib>Singh, V</creatorcontrib><creatorcontrib>Singh, S</creatorcontrib><creatorcontrib>Bhatnagar, S</creatorcontrib><creatorcontrib>Saini, D</creatorcontrib><creatorcontrib>Grewal, H M S</creatorcontrib><creatorcontrib>Lodha, R</creatorcontrib><creatorcontrib>Delhi TB Study group</creatorcontrib><title>Effect of micronutrient deficiency on QuantiFERON-TB Gold In-Tube test and tuberculin skin test in diagnosis of childhood intrathoracic tuberculosis</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives:
Data on performance of QuantiFERON-TB Gold In-Tube test (QFT) and tuberculin skin test (TST) in children with active tuberculosis from high burden countries in the context of micronutrient deficiency are scarce. The objective of this study was to evaluate the effect of micronutrient deficiency on the performance of TST and QFT in children with intrathoracic tuberculosis.
subjects/Methods:
Children with probable intrathoracic tuberculosis underwent TST, QFT, gastric lavages and induced sputum examination for AFB (Acid-Fast Bacilli) smear and culture. Zinc, copper, ferritin and vitamin D were measured on stored serum samples. The study used cross-sectional data at initiation of anti-tubercular therapy.
Results:
Three hundred and sixty-two children (median age 115.5 months (interquartile range: 73, 144), 200 (55.3%) girls) were enrolled in the study. Microbiological confirmation of tuberculosis could be obtained in 128 patients. TST and QFT were positive in 337 (93%) and 297 (82%) children, respectively. Performance of both the tests was unaffected by weight-for-age and height-for-age ‘
z
-scores’ or by serum copper levels. TST was not affected by serum zinc and ferritin levels. Children with negative QFT results had lower mean serum zinc level (
P
=0.01) and higher ferritin levels (
P
=0.007) as compared to those with positive test. Higher proportion of children with positive TST were vitamin D deficient/insufficient (
P
=0.003).
Conclusion:
Micronutrient status, especially serum levels of zinc, may influence the performance of QFT in children with intrathoracic tuberculosis. Considering the high prevalence of zinc deficiency in developing countries, QFT should be used cautiously for diagnosing tuberculosis.</description><subject>692/699/1702/295</subject><subject>692/699/255/1856</subject><subject>692/700/139</subject><subject>692/700/1720</subject><subject>Adolescent</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Childrens health</subject><subject>Clinical Nutrition</subject><subject>Copper</subject><subject>Copper - blood</subject><subject>Cross-Sectional Studies</subject><subject>Developing countries</subject><subject>Diagnosis</subject><subject>Diagnostic tests</subject><subject>Diseases</subject><subject>Double-Blind Method</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Ferritins - blood</subject><subject>Gold</subject><subject>Humans</subject><subject>India</subject><subject>Infant</subject><subject>Internal Medicine</subject><subject>LDCs</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Metabolic Diseases</subject><subject>Methods</subject><subject>Micronutrients - administration & dosage</subject><subject>Micronutrients - deficiency</subject><subject>Mycobacterium</subject><subject>Nutrition</subject><subject>original-article</subject><subject>Prevalence</subject><subject>Public Health</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Skin tests</subject><subject>Tuberculin Test - methods</subject><subject>Tuberculosis</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - drug therapy</subject><subject>Vitamin D</subject><subject>Vitamin D - blood</subject><subject>Zinc</subject><subject>Zinc - blood</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk1v1DAQhi0EotvCkSuyhIR6yWInjhMfS7UtlSoq0HK2HH_sesnaxXYO_R_8YCZsKQVxQLI8Y83j8cz4RegVJUtKmv6d3emwrAltljXlT9CCso5XLWfkKVoQ0bKqIaQ7Qsc57wiBYFc_R0c1o1wwThfo-8o5qwuODu-9TjFMJXkbCjbWeQ2evsMx4E-TCsVfrD7ffKzW7_FlHA2-CtV6GiwuNhesgsEFTklPow84f4XtZwCs8WoTYvZ5fkVv_Wi2MRqIlKTKNialvX64PHMv0DOnxmxf3tsT9OVitT7_UF3fXF6dn11XmglaKu1aawfOdUu6XrSUWGqYNg3RVrumHgQzfd3WpO85o0PHtLNqAIc7wYigbXOCTg95b1P8NkG1cu-ztuOogo1TloCwvuE9_w-UCdJRmHsP6Ju_0F2cUoBGgOpaSoXgzW9qo0YrfXARpqHnpPKsaTvBYRGg3j6itlaNZZvjOBUfQ_4TrA4g_GHOyTp5m_xepTtJiZyFImehyFkoEoQC_Ov7Iqdhb80D_UsZACwPQIZQ2Nj0qIt_ZvwBjbDHwg</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Mukherjee, A</creator><creator>Saini, S</creator><creator>Kabra, S K</creator><creator>Gupta, N</creator><creator>Singh, V</creator><creator>Singh, S</creator><creator>Bhatnagar, S</creator><creator>Saini, D</creator><creator>Grewal, H M S</creator><creator>Lodha, R</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20140101</creationdate><title>Effect of micronutrient deficiency on QuantiFERON-TB Gold In-Tube test and tuberculin skin test in diagnosis of childhood intrathoracic tuberculosis</title><author>Mukherjee, A ; Saini, S ; Kabra, S K ; Gupta, N ; Singh, V ; Singh, S ; Bhatnagar, S ; Saini, D ; Grewal, H M S ; Lodha, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-cf5eeb66c50789510e1d4cd30cecf32b94d8252088641b74cfeab1b76f9409153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>692/699/1702/295</topic><topic>692/699/255/1856</topic><topic>692/700/139</topic><topic>692/700/1720</topic><topic>Adolescent</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Childrens health</topic><topic>Clinical Nutrition</topic><topic>Copper</topic><topic>Copper - blood</topic><topic>Cross-Sectional Studies</topic><topic>Developing countries</topic><topic>Diagnosis</topic><topic>Diagnostic tests</topic><topic>Diseases</topic><topic>Double-Blind Method</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Ferritins - blood</topic><topic>Gold</topic><topic>Humans</topic><topic>India</topic><topic>Infant</topic><topic>Internal Medicine</topic><topic>LDCs</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Metabolic Diseases</topic><topic>Methods</topic><topic>Micronutrients - administration & dosage</topic><topic>Micronutrients - deficiency</topic><topic>Mycobacterium</topic><topic>Nutrition</topic><topic>original-article</topic><topic>Prevalence</topic><topic>Public Health</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Skin tests</topic><topic>Tuberculin Test - methods</topic><topic>Tuberculosis</topic><topic>Tuberculosis - diagnosis</topic><topic>Tuberculosis - drug therapy</topic><topic>Vitamin D</topic><topic>Vitamin D - blood</topic><topic>Zinc</topic><topic>Zinc - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mukherjee, A</creatorcontrib><creatorcontrib>Saini, S</creatorcontrib><creatorcontrib>Kabra, S K</creatorcontrib><creatorcontrib>Gupta, N</creatorcontrib><creatorcontrib>Singh, V</creatorcontrib><creatorcontrib>Singh, S</creatorcontrib><creatorcontrib>Bhatnagar, S</creatorcontrib><creatorcontrib>Saini, D</creatorcontrib><creatorcontrib>Grewal, H M S</creatorcontrib><creatorcontrib>Lodha, R</creatorcontrib><creatorcontrib>Delhi TB Study group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mukherjee, A</au><au>Saini, S</au><au>Kabra, S K</au><au>Gupta, N</au><au>Singh, V</au><au>Singh, S</au><au>Bhatnagar, S</au><au>Saini, D</au><au>Grewal, H M S</au><au>Lodha, R</au><aucorp>Delhi TB Study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of micronutrient deficiency on QuantiFERON-TB Gold In-Tube test and tuberculin skin test in diagnosis of childhood intrathoracic tuberculosis</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>68</volume><issue>1</issue><spage>38</spage><epage>42</epage><pages>38-42</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background/Objectives:
Data on performance of QuantiFERON-TB Gold In-Tube test (QFT) and tuberculin skin test (TST) in children with active tuberculosis from high burden countries in the context of micronutrient deficiency are scarce. The objective of this study was to evaluate the effect of micronutrient deficiency on the performance of TST and QFT in children with intrathoracic tuberculosis.
subjects/Methods:
Children with probable intrathoracic tuberculosis underwent TST, QFT, gastric lavages and induced sputum examination for AFB (Acid-Fast Bacilli) smear and culture. Zinc, copper, ferritin and vitamin D were measured on stored serum samples. The study used cross-sectional data at initiation of anti-tubercular therapy.
Results:
Three hundred and sixty-two children (median age 115.5 months (interquartile range: 73, 144), 200 (55.3%) girls) were enrolled in the study. Microbiological confirmation of tuberculosis could be obtained in 128 patients. TST and QFT were positive in 337 (93%) and 297 (82%) children, respectively. Performance of both the tests was unaffected by weight-for-age and height-for-age ‘
z
-scores’ or by serum copper levels. TST was not affected by serum zinc and ferritin levels. Children with negative QFT results had lower mean serum zinc level (
P
=0.01) and higher ferritin levels (
P
=0.007) as compared to those with positive test. Higher proportion of children with positive TST were vitamin D deficient/insufficient (
P
=0.003).
Conclusion:
Micronutrient status, especially serum levels of zinc, may influence the performance of QFT in children with intrathoracic tuberculosis. Considering the high prevalence of zinc deficiency in developing countries, QFT should be used cautiously for diagnosing tuberculosis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24169461</pmid><doi>10.1038/ejcn.2013.216</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2014-01, Vol.68 (1), p.38-42 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1534836865 |
| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 692/699/1702/295 692/699/255/1856 692/700/139 692/700/1720 Adolescent Antitubercular Agents - therapeutic use Child Child, Preschool Children Childrens health Clinical Nutrition Copper Copper - blood Cross-Sectional Studies Developing countries Diagnosis Diagnostic tests Diseases Double-Blind Method Epidemiology Female Ferritins - blood Gold Humans India Infant Internal Medicine LDCs Male Medical research Medicine Medicine & Public Health Medicine, Experimental Metabolic Diseases Methods Micronutrients - administration & dosage Micronutrients - deficiency Mycobacterium Nutrition original-article Prevalence Public Health Randomized Controlled Trials as Topic Skin tests Tuberculin Test - methods Tuberculosis Tuberculosis - diagnosis Tuberculosis - drug therapy Vitamin D Vitamin D - blood Zinc Zinc - blood |
| title | Effect of micronutrient deficiency on QuantiFERON-TB Gold In-Tube test and tuberculin skin test in diagnosis of childhood intrathoracic tuberculosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T09%3A42%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20micronutrient%20deficiency%20on%20QuantiFERON-TB%20Gold%20In-Tube%20test%20and%20tuberculin%20skin%20test%20in%20diagnosis%20of%20childhood%20intrathoracic%20tuberculosis&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=Mukherjee,%20A&rft.aucorp=Delhi%20TB%20Study%20group&rft.date=2014-01-01&rft.volume=68&rft.issue=1&rft.spage=38&rft.epage=42&rft.pages=38-42&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/ejcn.2013.216&rft_dat=%3Cgale_proqu%3EA357967960%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1475119963&rft_id=info:pmid/24169461&rft_galeid=A357967960&rfr_iscdi=true |