Neomaclafungins A–I: Oligomycin-Class Macrolides from a Marine-Derived Actinomycete
Nine new 26-membered macrolides of the oligomycin subfamily, neomaclafungins A–I, were isolated from the fermentation broth of Actinoalloteichus sp. NPS702, which was isolated from marine sediment collected from Usa Bay, Kochi Prefecture, Japan. Their structures were identified through mass spectrom...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2012-11, Vol.75 (11), p.1974-1982 |
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| container_end_page | 1982 |
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| container_issue | 11 |
| container_start_page | 1974 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 75 |
| creator | Sato, Seizo Iwata, Fumie Yamada, Shoichi Katayama, Masashi |
| description | Nine new 26-membered macrolides of the oligomycin subfamily, neomaclafungins A–I, were isolated from the fermentation broth of Actinoalloteichus sp. NPS702, which was isolated from marine sediment collected from Usa Bay, Kochi Prefecture, Japan. Their structures were identified through mass spectrometry and NMR experiments. They belong to the oligomycin class and have several distinct features including the presence of alkane or alkanol branches. Neomaclafungins A–I exhibited significant antifungal activity in vitro against Trichophyton mentagrophytes (ATCC 9533), showing MIC values between 1 and 3 μg/mL. |
| doi_str_mv | 10.1021/np300719g |
| format | Article |
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NPS702, which was isolated from marine sediment collected from Usa Bay, Kochi Prefecture, Japan. Their structures were identified through mass spectrometry and NMR experiments. They belong to the oligomycin class and have several distinct features including the presence of alkane or alkanol branches. 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Neomaclafungins A–I exhibited significant antifungal activity in vitro against Trichophyton mentagrophytes (ATCC 9533), showing MIC values between 1 and 3 μg/mL.</description><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Antifungal Agents - pharmacology</subject><subject>Japan</subject><subject>Marine Biology</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Oligomycins - chemistry</subject><subject>Oligomycins - isolation & purification</subject><subject>Oligomycins - pharmacology</subject><subject>Streptomyces - chemistry</subject><subject>Trichophyton - drug effects</subject><subject>Trichophyton mentagrophytes</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MtKw0AUBuBBFFurC19AshF0ET1zSzruSr0Vqt3UdZgkJ2VKLnUmEbrzHXxDn8QprV0JrgYO3_k58xNyTuGGAqO39YoDxFQtDkifSgZhBEwekj7QiId8GIkeOXFuCQAclDwmPcb9nqDQJ2-v2FQ6K3XR1QtTu2D0_fk1uQtmpVk01TozdTgutXPBi85sU5ocXVDYpgq0n1hTY3iP1nxgHoyy1tSbFWzxlBwVunR4tnsHZP74MB8_h9PZ02Q8moZaUNGGKde8gCFlPI0FMlAQKyUQlZIADFCyNIoEE4UWXHsIkEfeKhRRATLmA3K1jV3Z5r1D1yaVcRmWpa6x6VxCJRdDLhQf_k-FUtRfoKSn11vqP-ycxSJZWVNpu04oJJu-k33f3l7sYru0wnwvfwv24HILdOaSZdPZ2vfxR9APLoWFRA</recordid><startdate>20121126</startdate><enddate>20121126</enddate><creator>Sato, Seizo</creator><creator>Iwata, Fumie</creator><creator>Yamada, Shoichi</creator><creator>Katayama, Masashi</creator><general>American Chemical Society and American Society of Pharmacognosy</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7TN</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope></search><sort><creationdate>20121126</creationdate><title>Neomaclafungins A–I: Oligomycin-Class Macrolides from a Marine-Derived Actinomycete</title><author>Sato, Seizo ; 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Nat. Prod</addtitle><date>2012-11-26</date><risdate>2012</risdate><volume>75</volume><issue>11</issue><spage>1974</spage><epage>1982</epage><pages>1974-1982</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><abstract>Nine new 26-membered macrolides of the oligomycin subfamily, neomaclafungins A–I, were isolated from the fermentation broth of Actinoalloteichus sp. NPS702, which was isolated from marine sediment collected from Usa Bay, Kochi Prefecture, Japan. Their structures were identified through mass spectrometry and NMR experiments. They belong to the oligomycin class and have several distinct features including the presence of alkane or alkanol branches. 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| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2012-11, Vol.75 (11), p.1974-1982 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1534834938 |
| source | MEDLINE; ACS Publications |
| subjects | Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Japan Marine Biology Microbial Sensitivity Tests Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oligomycins - chemistry Oligomycins - isolation & purification Oligomycins - pharmacology Streptomyces - chemistry Trichophyton - drug effects Trichophyton mentagrophytes |
| title | Neomaclafungins A–I: Oligomycin-Class Macrolides from a Marine-Derived Actinomycete |
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