Neomaclafungins A–I: Oligomycin-Class Macrolides from a Marine-Derived Actinomycete

Nine new 26-membered macrolides of the oligomycin subfamily, neomaclafungins A–I, were isolated from the fermentation broth of Actinoalloteichus sp. NPS702, which was isolated from marine sediment collected from Usa Bay, Kochi Prefecture, Japan. Their structures were identified through mass spectrom...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2012-11, Vol.75 (11), p.1974-1982
Hauptverfasser:	Sato, Seizo, Iwata, Fumie, Yamada, Shoichi, Katayama, Masashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Japan Marine Biology Microbial Sensitivity Tests Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oligomycins - chemistry Oligomycins - isolation & purification Oligomycins - pharmacology Streptomyces - chemistry Trichophyton - drug effects Trichophyton mentagrophytes
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Beschreibung
Zusammenfassung:	Nine new 26-membered macrolides of the oligomycin subfamily, neomaclafungins A–I, were isolated from the fermentation broth of Actinoalloteichus sp. NPS702, which was isolated from marine sediment collected from Usa Bay, Kochi Prefecture, Japan. Their structures were identified through mass spectrometry and NMR experiments. They belong to the oligomycin class and have several distinct features including the presence of alkane or alkanol branches. Neomaclafungins A–I exhibited significant antifungal activity in vitro against Trichophyton mentagrophytes (ATCC 9533), showing MIC values between 1 and 3 μg/mL.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np300719g