Interethnic differences in the relevance of CYP2C9 genotype and environmental factors for diclofenac metabolism in Hispanics from Cuba and Spain

The aims of this study were to evaluate the diclofenac metabolism in Hispanics from Cuba and Spain and its relation to ethnicity, CYP2C9 genotypes and environmental factors. Diclofenac hydroxylation capacity (concentration ratios of diclofenac/metabolites in 8-h urine) was studied in 160 Cuban (clas...

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Veröffentlicht in:	The pharmacogenomics journal 2014-06, Vol.14 (3), p.229-234
Hauptverfasser:	Llerena, A, Alvarez, M, Dorado, P, González, I, Peñas-LLedó, E, Pérez, B, Cobaleda, J, Calzadilla, L R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436/434 692/700/478 Alleles Anti-Inflammatory Agents, Non-Steroidal - metabolism Biomedical and Life Sciences Biomedicine Caffeine Cuba - ethnology Cytochrome P-450 Cytochrome P-450 CYP2C9 - genetics Diclofenac Diclofenac - metabolism Drug metabolism Environmental factors Ethanol Ethnic Groups - genetics Ethnicity Gene Expression Genetic aspects Genetic research Genotype Genotypes Human Genetics Humans Hydroxylation Metabolism Metabolites Nonsteroidal anti-inflammatory drugs Oncology original-article Pharmacotherapy Polymorphism, Genetic Properties Psychopharmacology Spain - ethnology
Online-Zugang:	Volltext
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