A 4-year-old girl with clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection
Rotavirus is a common cause of severe gastroenteritis in children. It is known that rotavirus gastroenteritis may be accompanied by neurological manifestations, including encephalitis/encephalopathy and seizures. We report a case of a 4-year-old girl with clinically mild encephalopathy with a revers...
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| Veröffentlicht in: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2013-02, Vol.19 (1), p.149-153 |
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| container_title | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy |
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| creator | Fuchigami, Tatsuo Goto, Kosei Hasegawa, Maki Saito, Katsuya Kida, Tomoko Hashimoto, Koji Inamo, Yasuji Fujita, Yukihiko Kuzuya, Mitsutaka |
| description | Rotavirus is a common cause of severe gastroenteritis in children. It is known that rotavirus gastroenteritis may be accompanied by neurological manifestations, including encephalitis/encephalopathy and seizures. We report a case of a 4-year-old girl with clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection. She was admitted to our hospital because of reduced level of consciousness, seizures, diarrhea, and vomiting. Fecal rotavirus antigen testing was positive. Cell counts in the cerebrospinal fluid (CSF) were normal. She had a normal serum sodium level on admission. Brain computed tomography showed no cerebral edema. However, electroencephalography showed generalized high-voltage slow waves, and diffusion-weighted magnetic resonance imaging demonstrated a transient abnormality in the splenium of the corpus callosum. We diagnosed clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection. She recovered well and exhibited no neurological sequelae. Rotavirus RNA and antigen were not detected in the CSF, suggesting that the reversible splenial change was caused by indirect effects on the central nervous system subsequent to viral infection. Her normal serum sodium level indicates that this change can occur without hyponatremia. |
| doi_str_mv | 10.1007/s10156-012-0421-8 |
| format | Article |
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It is known that rotavirus gastroenteritis may be accompanied by neurological manifestations, including encephalitis/encephalopathy and seizures. We report a case of a 4-year-old girl with clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection. She was admitted to our hospital because of reduced level of consciousness, seizures, diarrhea, and vomiting. Fecal rotavirus antigen testing was positive. Cell counts in the cerebrospinal fluid (CSF) were normal. She had a normal serum sodium level on admission. Brain computed tomography showed no cerebral edema. However, electroencephalography showed generalized high-voltage slow waves, and diffusion-weighted magnetic resonance imaging demonstrated a transient abnormality in the splenium of the corpus callosum. We diagnosed clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection. She recovered well and exhibited no neurological sequelae. Rotavirus RNA and antigen were not detected in the CSF, suggesting that the reversible splenial change was caused by indirect effects on the central nervous system subsequent to viral infection. Her normal serum sodium level indicates that this change can occur without hyponatremia.</description><identifier>ISSN: 1341-321X</identifier><identifier>EISSN: 1437-7780</identifier><identifier>DOI: 10.1007/s10156-012-0421-8</identifier><identifier>PMID: 22569794</identifier><language>eng</language><publisher>Japan: Elsevier Ltd</publisher><subject>Brain Diseases - pathology ; Brain Diseases - virology ; Case Report ; Child, Preschool ; Corpus callosum ; Corpus Callosum - pathology ; Diffusion Magnetic Resonance Imaging ; Diffusion-weighted imaging ; Electroencephalography ; Encephalopathy ; Female ; Gastroenteritis - complications ; Gastroenteritis - virology ; Hematology, Oncology and Palliative Medicine ; Humans ; Infectious Diseases ; Medical Microbiology ; Medicine ; Medicine & Public Health ; Rotavirus ; Rotavirus - genetics ; Rotavirus - isolation & purification ; Rotavirus Infections - complications ; Rotavirus Infections - virology ; Splenial lesion ; Virology</subject><ispartof>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2013-02, Vol.19 (1), p.149-153</ispartof><rights>Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases</rights><rights>2013 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases</rights><rights>Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-961106661256cc868d7556c5e798cbbb9e7c171d5ce0f8dc9cea503e6fdbe2563</citedby><cites>FETCH-LOGICAL-c537t-961106661256cc868d7556c5e798cbbb9e7c171d5ce0f8dc9cea503e6fdbe2563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10156-012-0421-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10156-012-0421-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22569794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuchigami, Tatsuo</creatorcontrib><creatorcontrib>Goto, Kosei</creatorcontrib><creatorcontrib>Hasegawa, Maki</creatorcontrib><creatorcontrib>Saito, Katsuya</creatorcontrib><creatorcontrib>Kida, Tomoko</creatorcontrib><creatorcontrib>Hashimoto, Koji</creatorcontrib><creatorcontrib>Inamo, Yasuji</creatorcontrib><creatorcontrib>Fujita, Yukihiko</creatorcontrib><creatorcontrib>Kuzuya, Mitsutaka</creatorcontrib><title>A 4-year-old girl with clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection</title><title>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</title><addtitle>J Infect Chemother</addtitle><addtitle>J Infect Chemother</addtitle><description>Rotavirus is a common cause of severe gastroenteritis in children. It is known that rotavirus gastroenteritis may be accompanied by neurological manifestations, including encephalitis/encephalopathy and seizures. We report a case of a 4-year-old girl with clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection. She was admitted to our hospital because of reduced level of consciousness, seizures, diarrhea, and vomiting. Fecal rotavirus antigen testing was positive. Cell counts in the cerebrospinal fluid (CSF) were normal. She had a normal serum sodium level on admission. Brain computed tomography showed no cerebral edema. However, electroencephalography showed generalized high-voltage slow waves, and diffusion-weighted magnetic resonance imaging demonstrated a transient abnormality in the splenium of the corpus callosum. We diagnosed clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection. She recovered well and exhibited no neurological sequelae. Rotavirus RNA and antigen were not detected in the CSF, suggesting that the reversible splenial change was caused by indirect effects on the central nervous system subsequent to viral infection. Her normal serum sodium level indicates that this change can occur without hyponatremia.</description><subject>Brain Diseases - pathology</subject><subject>Brain Diseases - virology</subject><subject>Case Report</subject><subject>Child, Preschool</subject><subject>Corpus callosum</subject><subject>Corpus Callosum - pathology</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Diffusion-weighted imaging</subject><subject>Electroencephalography</subject><subject>Encephalopathy</subject><subject>Female</subject><subject>Gastroenteritis - complications</subject><subject>Gastroenteritis - virology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Medical Microbiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Rotavirus</subject><subject>Rotavirus - genetics</subject><subject>Rotavirus - isolation & purification</subject><subject>Rotavirus Infections - complications</subject><subject>Rotavirus Infections - virology</subject><subject>Splenial lesion</subject><subject>Virology</subject><issn>1341-321X</issn><issn>1437-7780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1q3TAQhU1padK0D9BN0bIbtRrJtmQKhRD6B4EukkJ3QpbHuUp1LVeybzB9-cg4aSGLdKWBOd_RMGeK4jWwd8CYfJ-AQVVTBpyykgNVT4pjKIWkUir2NNeiBCo4_DwqXqR0zRjISqnnxRHnVd3Ipjwu_pySki5oIg2-I1cuenLjph2x3g3OGu8Xsne5g4PFcWd8GM20WzaNIREPGJNrPZI0ehyc8cRjcmEgJqVgnZmw28QxTObg4pyIG3q0U9a8LJ71xid8dfeeFD8-f7o8-0rPv3_5dnZ6Tm0l5ESbGoDVdQ15aGtVrTpZ5apC2Sjbtm2D0oKErrLIetXZxqKpmMC671rMjDgp3m6-Ywy_Z0yT3rtk0XszYJiThkqUSvCS8_9LuVJNwxlfXWGT2hhSitjrMbq9iYsGptd49BaPzvHoNR6tMvPmzn5u99j9Je7zyAK-CVJuDVcY9XWY45C386jrhw3CvMSDy1Cybg2sczFvWnfBPUp_fEDfZ_8LF0z__tcpM_piPar1pkBIBo0oxS3AfcR8</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Fuchigami, Tatsuo</creator><creator>Goto, Kosei</creator><creator>Hasegawa, Maki</creator><creator>Saito, Katsuya</creator><creator>Kida, Tomoko</creator><creator>Hashimoto, Koji</creator><creator>Inamo, Yasuji</creator><creator>Fujita, Yukihiko</creator><creator>Kuzuya, Mitsutaka</creator><general>Elsevier Ltd</general><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20130201</creationdate><title>A 4-year-old girl with clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection</title><author>Fuchigami, Tatsuo ; Goto, Kosei ; Hasegawa, Maki ; Saito, Katsuya ; Kida, Tomoko ; Hashimoto, Koji ; Inamo, Yasuji ; Fujita, Yukihiko ; Kuzuya, Mitsutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-961106661256cc868d7556c5e798cbbb9e7c171d5ce0f8dc9cea503e6fdbe2563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Brain Diseases - pathology</topic><topic>Brain Diseases - virology</topic><topic>Case Report</topic><topic>Child, Preschool</topic><topic>Corpus callosum</topic><topic>Corpus Callosum - pathology</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Diffusion-weighted imaging</topic><topic>Electroencephalography</topic><topic>Encephalopathy</topic><topic>Female</topic><topic>Gastroenteritis - complications</topic><topic>Gastroenteritis - virology</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Medical Microbiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Rotavirus</topic><topic>Rotavirus - genetics</topic><topic>Rotavirus - isolation & purification</topic><topic>Rotavirus Infections - complications</topic><topic>Rotavirus Infections - virology</topic><topic>Splenial lesion</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuchigami, Tatsuo</creatorcontrib><creatorcontrib>Goto, Kosei</creatorcontrib><creatorcontrib>Hasegawa, Maki</creatorcontrib><creatorcontrib>Saito, Katsuya</creatorcontrib><creatorcontrib>Kida, Tomoko</creatorcontrib><creatorcontrib>Hashimoto, Koji</creatorcontrib><creatorcontrib>Inamo, Yasuji</creatorcontrib><creatorcontrib>Fujita, Yukihiko</creatorcontrib><creatorcontrib>Kuzuya, Mitsutaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuchigami, Tatsuo</au><au>Goto, Kosei</au><au>Hasegawa, Maki</au><au>Saito, Katsuya</au><au>Kida, Tomoko</au><au>Hashimoto, Koji</au><au>Inamo, Yasuji</au><au>Fujita, Yukihiko</au><au>Kuzuya, Mitsutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A 4-year-old girl with clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection</atitle><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle><stitle>J Infect Chemother</stitle><addtitle>J Infect Chemother</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>19</volume><issue>1</issue><spage>149</spage><epage>153</epage><pages>149-153</pages><issn>1341-321X</issn><eissn>1437-7780</eissn><abstract>Rotavirus is a common cause of severe gastroenteritis in children. It is known that rotavirus gastroenteritis may be accompanied by neurological manifestations, including encephalitis/encephalopathy and seizures. We report a case of a 4-year-old girl with clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection. She was admitted to our hospital because of reduced level of consciousness, seizures, diarrhea, and vomiting. Fecal rotavirus antigen testing was positive. Cell counts in the cerebrospinal fluid (CSF) were normal. She had a normal serum sodium level on admission. Brain computed tomography showed no cerebral edema. However, electroencephalography showed generalized high-voltage slow waves, and diffusion-weighted magnetic resonance imaging demonstrated a transient abnormality in the splenium of the corpus callosum. We diagnosed clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection. She recovered well and exhibited no neurological sequelae. Rotavirus RNA and antigen were not detected in the CSF, suggesting that the reversible splenial change was caused by indirect effects on the central nervous system subsequent to viral infection. Her normal serum sodium level indicates that this change can occur without hyponatremia.</abstract><cop>Japan</cop><pub>Elsevier Ltd</pub><pmid>22569794</pmid><doi>10.1007/s10156-012-0421-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2013-02, Vol.19 (1), p.149-153 |
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| subjects | Brain Diseases - pathology Brain Diseases - virology Case Report Child, Preschool Corpus callosum Corpus Callosum - pathology Diffusion Magnetic Resonance Imaging Diffusion-weighted imaging Electroencephalography Encephalopathy Female Gastroenteritis - complications Gastroenteritis - virology Hematology, Oncology and Palliative Medicine Humans Infectious Diseases Medical Microbiology Medicine Medicine & Public Health Rotavirus Rotavirus - genetics Rotavirus - isolation & purification Rotavirus Infections - complications Rotavirus Infections - virology Splenial lesion Virology |
| title | A 4-year-old girl with clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection |
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