Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages
Aim Chromosomal abnormalities are an important cause of repeated miscarriage. Several studies have discussed the association between chromosomal abnormalities and repeated miscarriage. This study attempts to describe the pattern of miscarriage in this group of women and the eventual pregnancy outcom...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2014-01, Vol.40 (1), p.109-116 |
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| container_title | The journal of obstetrics and gynaecology research |
| container_volume | 40 |
| creator | Flynn, Helen Yan, Junhao Saravelos, Sotirios H. Li, Tin-Chiu |
| description | Aim
Chromosomal abnormalities are an important cause of repeated miscarriage. Several studies have discussed the association between chromosomal abnormalities and repeated miscarriage. This study attempts to describe the pattern of miscarriage in this group of women and the eventual pregnancy outcome of couples with chromosomal abnormalities compared with couples with unexplained repeated pregnancy loss.
Material and Methods
This was a retrospective study involving 795 couples with repeated miscarriages.
Results
Out of 795 couples, 28 (3.52%) were found to have a chromosomal abnormality (carrier group). Over half (65.5%) of the chromosomal abnormalities were balanced reciprocal translocations. After referral, this carrier group had a total of 159 pregnancies, leading to 36 live births (22.6%) among 18 couples. The after referral miscarriage rate in the chromosomal anomaly group (55.6%) was significantly (P |
| doi_str_mv | 10.1111/jog.12133 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1534831296</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1534831296</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4203-23a8eec9451c37d1ffb89b3a1716fbd5f9805cb656e667c1ef6b8a9bfa4bc6d23</originalsourceid><addsrcrecordid>eNqFkctu1TAQhiMEohdY8ALIS5Ca1o5vyRId6OFS0Q2XpWU7k3Nckji1HU77OjwpPk3bHWI280v-5h9r_qJ4RfApyXV25TenpCKUPikOCWOyxJKLp1lTRsoaS3FQHMV4hTGRDamfFwcVw5RyJg6LPys_TDq46EfkOxRgCr6dbXK_Afk5WT_ACXKj7efWjRuUtoAmnRKEO7z3MZ4gA2kHMCLr56mHiHYubZHdBj_46AfdI21GH7JwyeVnPbbZx0dYwHmEm6nXboR2vx50ymJw0eoQnN5AfFE863Qf4eV9Py6-n3_4tvpYXlyuP63eXZSWVZiWFdU1gG0YJ5bKlnSdqRtDNZFEdKblXVNjbo3gAoSQlkAnTK0b02lmrGgrely8WXzzCa5niEntfwF9r0fwc1SEU1ZTUjXi_yhrcgSkrnhG3y6oDflYATo1BTfocKsIVvv0VE5P3aWX2df3trMZoH0kH-LKwNkC7FwPt_92Up8v1w-W5TLhYoKbxwkdfikhqeTq59e1ovUPjr_I92pN_wJxpbeQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1490751825</pqid></control><display><type>article</type><title>Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Flynn, Helen ; Yan, Junhao ; Saravelos, Sotirios H. ; Li, Tin-Chiu</creator><creatorcontrib>Flynn, Helen ; Yan, Junhao ; Saravelos, Sotirios H. ; Li, Tin-Chiu</creatorcontrib><description>Aim
Chromosomal abnormalities are an important cause of repeated miscarriage. Several studies have discussed the association between chromosomal abnormalities and repeated miscarriage. This study attempts to describe the pattern of miscarriage in this group of women and the eventual pregnancy outcome of couples with chromosomal abnormalities compared with couples with unexplained repeated pregnancy loss.
Material and Methods
This was a retrospective study involving 795 couples with repeated miscarriages.
Results
Out of 795 couples, 28 (3.52%) were found to have a chromosomal abnormality (carrier group). Over half (65.5%) of the chromosomal abnormalities were balanced reciprocal translocations. After referral, this carrier group had a total of 159 pregnancies, leading to 36 live births (22.6%) among 18 couples. The after referral miscarriage rate in the chromosomal anomaly group (55.6%) was significantly (P < 0.01) higher than that in the unexplained recurrent miscarriage group (28.1%). In couples with chromosomal anomaly, the miscarriages were more likely to occur between 6 and 12 weeks' gestation.
Conclusions
The encouraging cumulative live birth rate of 64.3% for couples with chromosomal anomaly and repeated miscarriage suggests that further attempts at natural conception are a viable option.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.12133</identifier><identifier>PMID: 24033546</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Abortion, Habitual - etiology ; Adult ; chromosomal abnormality ; Chromosome Aberrations ; Embryo Implantation ; Embryo Loss - etiology ; Embryo Loss - genetics ; Embryo Loss - physiopathology ; Family Characteristics ; Female ; Fetal Death - etiology ; Fetal Death - genetics ; Fetal Death - physiopathology ; Heterozygote ; Humans ; Live Birth ; Male ; Pregnancy ; Pregnancy, Ectopic - physiopathology ; repeated miscarriage ; Retrospective Studies ; Translocation, Genetic</subject><ispartof>The journal of obstetrics and gynaecology research, 2014-01, Vol.40 (1), p.109-116</ispartof><rights>2013 The Authors. Journal of Obstetrics and Gynaecology Research © 2013 Japan Society of Obstetrics and Gynecology</rights><rights>2013 The Authors. Journal of Obstetrics and Gynaecology Research © 2013 Japan Society of Obstetrics and Gynecology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4203-23a8eec9451c37d1ffb89b3a1716fbd5f9805cb656e667c1ef6b8a9bfa4bc6d23</citedby><cites>FETCH-LOGICAL-c4203-23a8eec9451c37d1ffb89b3a1716fbd5f9805cb656e667c1ef6b8a9bfa4bc6d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.12133$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.12133$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24033546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flynn, Helen</creatorcontrib><creatorcontrib>Yan, Junhao</creatorcontrib><creatorcontrib>Saravelos, Sotirios H.</creatorcontrib><creatorcontrib>Li, Tin-Chiu</creatorcontrib><title>Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim
Chromosomal abnormalities are an important cause of repeated miscarriage. Several studies have discussed the association between chromosomal abnormalities and repeated miscarriage. This study attempts to describe the pattern of miscarriage in this group of women and the eventual pregnancy outcome of couples with chromosomal abnormalities compared with couples with unexplained repeated pregnancy loss.
Material and Methods
This was a retrospective study involving 795 couples with repeated miscarriages.
Results
Out of 795 couples, 28 (3.52%) were found to have a chromosomal abnormality (carrier group). Over half (65.5%) of the chromosomal abnormalities were balanced reciprocal translocations. After referral, this carrier group had a total of 159 pregnancies, leading to 36 live births (22.6%) among 18 couples. The after referral miscarriage rate in the chromosomal anomaly group (55.6%) was significantly (P < 0.01) higher than that in the unexplained recurrent miscarriage group (28.1%). In couples with chromosomal anomaly, the miscarriages were more likely to occur between 6 and 12 weeks' gestation.
Conclusions
The encouraging cumulative live birth rate of 64.3% for couples with chromosomal anomaly and repeated miscarriage suggests that further attempts at natural conception are a viable option.</description><subject>Abortion, Habitual - etiology</subject><subject>Adult</subject><subject>chromosomal abnormality</subject><subject>Chromosome Aberrations</subject><subject>Embryo Implantation</subject><subject>Embryo Loss - etiology</subject><subject>Embryo Loss - genetics</subject><subject>Embryo Loss - physiopathology</subject><subject>Family Characteristics</subject><subject>Female</subject><subject>Fetal Death - etiology</subject><subject>Fetal Death - genetics</subject><subject>Fetal Death - physiopathology</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Live Birth</subject><subject>Male</subject><subject>Pregnancy</subject><subject>Pregnancy, Ectopic - physiopathology</subject><subject>repeated miscarriage</subject><subject>Retrospective Studies</subject><subject>Translocation, Genetic</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1TAQhiMEohdY8ALIS5Ca1o5vyRId6OFS0Q2XpWU7k3Nckji1HU77OjwpPk3bHWI280v-5h9r_qJ4RfApyXV25TenpCKUPikOCWOyxJKLp1lTRsoaS3FQHMV4hTGRDamfFwcVw5RyJg6LPys_TDq46EfkOxRgCr6dbXK_Afk5WT_ACXKj7efWjRuUtoAmnRKEO7z3MZ4gA2kHMCLr56mHiHYubZHdBj_46AfdI21GH7JwyeVnPbbZx0dYwHmEm6nXboR2vx50ymJw0eoQnN5AfFE863Qf4eV9Py6-n3_4tvpYXlyuP63eXZSWVZiWFdU1gG0YJ5bKlnSdqRtDNZFEdKblXVNjbo3gAoSQlkAnTK0b02lmrGgrely8WXzzCa5niEntfwF9r0fwc1SEU1ZTUjXi_yhrcgSkrnhG3y6oDflYATo1BTfocKsIVvv0VE5P3aWX2df3trMZoH0kH-LKwNkC7FwPt_92Up8v1w-W5TLhYoKbxwkdfikhqeTq59e1ovUPjr_I92pN_wJxpbeQ</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Flynn, Helen</creator><creator>Yan, Junhao</creator><creator>Saravelos, Sotirios H.</creator><creator>Li, Tin-Chiu</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201401</creationdate><title>Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages</title><author>Flynn, Helen ; Yan, Junhao ; Saravelos, Sotirios H. ; Li, Tin-Chiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4203-23a8eec9451c37d1ffb89b3a1716fbd5f9805cb656e667c1ef6b8a9bfa4bc6d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abortion, Habitual - etiology</topic><topic>Adult</topic><topic>chromosomal abnormality</topic><topic>Chromosome Aberrations</topic><topic>Embryo Implantation</topic><topic>Embryo Loss - etiology</topic><topic>Embryo Loss - genetics</topic><topic>Embryo Loss - physiopathology</topic><topic>Family Characteristics</topic><topic>Female</topic><topic>Fetal Death - etiology</topic><topic>Fetal Death - genetics</topic><topic>Fetal Death - physiopathology</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Live Birth</topic><topic>Male</topic><topic>Pregnancy</topic><topic>Pregnancy, Ectopic - physiopathology</topic><topic>repeated miscarriage</topic><topic>Retrospective Studies</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flynn, Helen</creatorcontrib><creatorcontrib>Yan, Junhao</creatorcontrib><creatorcontrib>Saravelos, Sotirios H.</creatorcontrib><creatorcontrib>Li, Tin-Chiu</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flynn, Helen</au><au>Yan, Junhao</au><au>Saravelos, Sotirios H.</au><au>Li, Tin-Chiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2014-01</date><risdate>2014</risdate><volume>40</volume><issue>1</issue><spage>109</spage><epage>116</epage><pages>109-116</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
Chromosomal abnormalities are an important cause of repeated miscarriage. Several studies have discussed the association between chromosomal abnormalities and repeated miscarriage. This study attempts to describe the pattern of miscarriage in this group of women and the eventual pregnancy outcome of couples with chromosomal abnormalities compared with couples with unexplained repeated pregnancy loss.
Material and Methods
This was a retrospective study involving 795 couples with repeated miscarriages.
Results
Out of 795 couples, 28 (3.52%) were found to have a chromosomal abnormality (carrier group). Over half (65.5%) of the chromosomal abnormalities were balanced reciprocal translocations. After referral, this carrier group had a total of 159 pregnancies, leading to 36 live births (22.6%) among 18 couples. The after referral miscarriage rate in the chromosomal anomaly group (55.6%) was significantly (P < 0.01) higher than that in the unexplained recurrent miscarriage group (28.1%). In couples with chromosomal anomaly, the miscarriages were more likely to occur between 6 and 12 weeks' gestation.
Conclusions
The encouraging cumulative live birth rate of 64.3% for couples with chromosomal anomaly and repeated miscarriage suggests that further attempts at natural conception are a viable option.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>24033546</pmid><doi>10.1111/jog.12133</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1341-8076 |
| ispartof | The journal of obstetrics and gynaecology research, 2014-01, Vol.40 (1), p.109-116 |
| issn | 1341-8076 1447-0756 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Abortion, Habitual - etiology Adult chromosomal abnormality Chromosome Aberrations Embryo Implantation Embryo Loss - etiology Embryo Loss - genetics Embryo Loss - physiopathology Family Characteristics Female Fetal Death - etiology Fetal Death - genetics Fetal Death - physiopathology Heterozygote Humans Live Birth Male Pregnancy Pregnancy, Ectopic - physiopathology repeated miscarriage Retrospective Studies Translocation, Genetic |
| title | Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages |
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