Regulation of BMI1 Polycomb gene expression in histological grades of invasive ductal breast carcinomas and its correlation with hormone receptor status
BMI1 is the first functional mammalian Polycomb group (PcG) proto-oncogene involved in multiple biological processes. Regulation of B cell-specific Moloney murine leukaemia virus integration site 1 (BMI1) expression with increase in histological grades of breast carcinoma in correlation with hormone...
Gespeichert in:
| Veröffentlicht in: | Tumor biology 2013-12, Vol.34 (6), p.3807-3815 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3815 |
|---|---|
| container_issue | 6 |
| container_start_page | 3807 |
| container_title | Tumor biology |
| container_volume | 34 |
| creator | Parvathi, M. V. S. Murthy, P. Balakrishna Vennila, M. Suresh, B. V. |
| description | BMI1 is the first functional mammalian Polycomb group (PcG) proto-oncogene involved in multiple biological processes. Regulation of B cell-specific Moloney murine leukaemia virus integration site 1 (BMI1) expression with increase in histological grades of breast carcinoma in correlation with hormone receptor status was studied in 60 Indian breast cancer patient's formalin-fixed paraffin-embedded tissue blocks. Relative expression of BMI1 was studied using real-time PCR. Immunohistochemistry explained the distribution of hormone receptor markers. Correlation of BMI1 gene expression with oestrogen receptor, progesterone receptor (PR) and human epidermal growth factor receptor 2/neu status was analysed using Hex—protein docking tool. The hormone receptor expression was reduced with increasing grades of breast tumour. BMI1 gene expression was downregulated (real-time polymerase chain reaction analysis). Docking analysis explained the correlation between BMI1 and PR expression. BMI1 gene was co-regulated (down) with PR in the invasive ductal breast carcinoma with relative progression explicating it a diagnostic biomarker for ductal carcinoma of the breast. |
| doi_str_mv | 10.1007/s13277-013-0965-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1534830523</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3152052841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-3eb52263d364598a5890f8fad437055989290b77e56621d36679fb9fc62418b13</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhS0EoqXwAGyQJTZsQv0TO84SqlIqFYEQrC3Hucm4SuLB1ynMm_Rx69EMCCGx8s_9zjlXOoS85OwtZ6w5Ry5F01SMy4q1WlW7R-SU16K8pGGPy51xVtXCyBPyDPGWMa7aVj8lJ0KaRnJmTsn9VxjXyeUQFxoH-v7TNadf4rTzce7oCAtQ-LVNgLgHwkI3AXOc4hi8m-iYXA-414XlzmG4A9qvPpdJl8Bhpt4lH5Y4O6Ru6WnISH1MCY6BP0Pe0E1Mcyw5CTxsc0wUs8srPidPBjchvDieZ-T7h8tvFx-rm89X1xfvbipfM5UrCZ0SQste6lq1xinTssEMrq9lw1T5aUXLuqYBpbXghdJNO3Tt4LWouem4PCNvDr7bFH-sgNnOAT1Mk1sgrmi5krWRTAlZ0Nf_oLdxTUvZzvJa67KH4axQ_ED5FBETDHabwuzSznJm97XZQ2221Gb3tdld0bw6Oq_dDP0fxe-eCiAOAJbRMkL6K_q_rg-Z3qR3</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1466522810</pqid></control><display><type>article</type><title>Regulation of BMI1 Polycomb gene expression in histological grades of invasive ductal breast carcinomas and its correlation with hormone receptor status</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Parvathi, M. V. S. ; Murthy, P. Balakrishna ; Vennila, M. ; Suresh, B. V.</creator><creatorcontrib>Parvathi, M. V. S. ; Murthy, P. Balakrishna ; Vennila, M. ; Suresh, B. V.</creatorcontrib><description>BMI1 is the first functional mammalian Polycomb group (PcG) proto-oncogene involved in multiple biological processes. Regulation of B cell-specific Moloney murine leukaemia virus integration site 1 (BMI1) expression with increase in histological grades of breast carcinoma in correlation with hormone receptor status was studied in 60 Indian breast cancer patient's formalin-fixed paraffin-embedded tissue blocks. Relative expression of BMI1 was studied using real-time PCR. Immunohistochemistry explained the distribution of hormone receptor markers. Correlation of BMI1 gene expression with oestrogen receptor, progesterone receptor (PR) and human epidermal growth factor receptor 2/neu status was analysed using Hex—protein docking tool. The hormone receptor expression was reduced with increasing grades of breast tumour. BMI1 gene expression was downregulated (real-time polymerase chain reaction analysis). Docking analysis explained the correlation between BMI1 and PR expression. BMI1 gene was co-regulated (down) with PR in the invasive ductal breast carcinoma with relative progression explicating it a diagnostic biomarker for ductal carcinoma of the breast.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-013-0965-y</identifier><identifier>PMID: 23873108</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cancer Research ; Carcinoma, Ductal, Breast - genetics ; Carcinoma, Ductal, Breast - metabolism ; Carcinoma, Ductal, Breast - pathology ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Histology ; Hormones ; Humans ; Immunohistochemistry ; Models, Molecular ; Murine leukemia virus ; Neoplasm Grading ; Polycomb Repressive Complex 1 - chemistry ; Polycomb Repressive Complex 1 - genetics ; Polycomb Repressive Complex 1 - metabolism ; Protein Binding ; Protein Structure, Tertiary ; Proteins ; Receptor, ErbB-2 - chemistry ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - chemistry ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - chemistry ; Receptors, Progesterone - metabolism ; Research Article ; Reverse Transcriptase Polymerase Chain Reaction</subject><ispartof>Tumor biology, 2013-12, Vol.34 (6), p.3807-3815</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-3eb52263d364598a5890f8fad437055989290b77e56621d36679fb9fc62418b13</citedby><cites>FETCH-LOGICAL-c405t-3eb52263d364598a5890f8fad437055989290b77e56621d36679fb9fc62418b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-013-0965-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-013-0965-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23873108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parvathi, M. V. S.</creatorcontrib><creatorcontrib>Murthy, P. Balakrishna</creatorcontrib><creatorcontrib>Vennila, M.</creatorcontrib><creatorcontrib>Suresh, B. V.</creatorcontrib><title>Regulation of BMI1 Polycomb gene expression in histological grades of invasive ductal breast carcinomas and its correlation with hormone receptor status</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>BMI1 is the first functional mammalian Polycomb group (PcG) proto-oncogene involved in multiple biological processes. Regulation of B cell-specific Moloney murine leukaemia virus integration site 1 (BMI1) expression with increase in histological grades of breast carcinoma in correlation with hormone receptor status was studied in 60 Indian breast cancer patient's formalin-fixed paraffin-embedded tissue blocks. Relative expression of BMI1 was studied using real-time PCR. Immunohistochemistry explained the distribution of hormone receptor markers. Correlation of BMI1 gene expression with oestrogen receptor, progesterone receptor (PR) and human epidermal growth factor receptor 2/neu status was analysed using Hex—protein docking tool. The hormone receptor expression was reduced with increasing grades of breast tumour. BMI1 gene expression was downregulated (real-time polymerase chain reaction analysis). Docking analysis explained the correlation between BMI1 and PR expression. BMI1 gene was co-regulated (down) with PR in the invasive ductal breast carcinoma with relative progression explicating it a diagnostic biomarker for ductal carcinoma of the breast.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Carcinoma, Ductal, Breast - genetics</subject><subject>Carcinoma, Ductal, Breast - metabolism</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Histology</subject><subject>Hormones</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Models, Molecular</subject><subject>Murine leukemia virus</subject><subject>Neoplasm Grading</subject><subject>Polycomb Repressive Complex 1 - chemistry</subject><subject>Polycomb Repressive Complex 1 - genetics</subject><subject>Polycomb Repressive Complex 1 - metabolism</subject><subject>Protein Binding</subject><subject>Protein Structure, Tertiary</subject><subject>Proteins</subject><subject>Receptor, ErbB-2 - chemistry</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Estrogen - chemistry</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - chemistry</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Research Article</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc1u1DAUhS0EoqXwAGyQJTZsQv0TO84SqlIqFYEQrC3Hucm4SuLB1ynMm_Rx69EMCCGx8s_9zjlXOoS85OwtZ6w5Ry5F01SMy4q1WlW7R-SU16K8pGGPy51xVtXCyBPyDPGWMa7aVj8lJ0KaRnJmTsn9VxjXyeUQFxoH-v7TNadf4rTzce7oCAtQ-LVNgLgHwkI3AXOc4hi8m-iYXA-414XlzmG4A9qvPpdJl8Bhpt4lH5Y4O6Ru6WnISH1MCY6BP0Pe0E1Mcyw5CTxsc0wUs8srPidPBjchvDieZ-T7h8tvFx-rm89X1xfvbipfM5UrCZ0SQste6lq1xinTssEMrq9lw1T5aUXLuqYBpbXghdJNO3Tt4LWouem4PCNvDr7bFH-sgNnOAT1Mk1sgrmi5krWRTAlZ0Nf_oLdxTUvZzvJa67KH4axQ_ED5FBETDHabwuzSznJm97XZQ2221Gb3tdld0bw6Oq_dDP0fxe-eCiAOAJbRMkL6K_q_rg-Z3qR3</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Parvathi, M. V. S.</creator><creator>Murthy, P. Balakrishna</creator><creator>Vennila, M.</creator><creator>Suresh, B. V.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20131201</creationdate><title>Regulation of BMI1 Polycomb gene expression in histological grades of invasive ductal breast carcinomas and its correlation with hormone receptor status</title><author>Parvathi, M. V. S. ; Murthy, P. Balakrishna ; Vennila, M. ; Suresh, B. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-3eb52263d364598a5890f8fad437055989290b77e56621d36679fb9fc62418b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer Research</topic><topic>Carcinoma, Ductal, Breast - genetics</topic><topic>Carcinoma, Ductal, Breast - metabolism</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Histology</topic><topic>Hormones</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Models, Molecular</topic><topic>Murine leukemia virus</topic><topic>Neoplasm Grading</topic><topic>Polycomb Repressive Complex 1 - chemistry</topic><topic>Polycomb Repressive Complex 1 - genetics</topic><topic>Polycomb Repressive Complex 1 - metabolism</topic><topic>Protein Binding</topic><topic>Protein Structure, Tertiary</topic><topic>Proteins</topic><topic>Receptor, ErbB-2 - chemistry</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Receptors, Estrogen - chemistry</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - chemistry</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Research Article</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parvathi, M. V. S.</creatorcontrib><creatorcontrib>Murthy, P. Balakrishna</creatorcontrib><creatorcontrib>Vennila, M.</creatorcontrib><creatorcontrib>Suresh, B. V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parvathi, M. V. S.</au><au>Murthy, P. Balakrishna</au><au>Vennila, M.</au><au>Suresh, B. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of BMI1 Polycomb gene expression in histological grades of invasive ductal breast carcinomas and its correlation with hormone receptor status</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>34</volume><issue>6</issue><spage>3807</spage><epage>3815</epage><pages>3807-3815</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>BMI1 is the first functional mammalian Polycomb group (PcG) proto-oncogene involved in multiple biological processes. Regulation of B cell-specific Moloney murine leukaemia virus integration site 1 (BMI1) expression with increase in histological grades of breast carcinoma in correlation with hormone receptor status was studied in 60 Indian breast cancer patient's formalin-fixed paraffin-embedded tissue blocks. Relative expression of BMI1 was studied using real-time PCR. Immunohistochemistry explained the distribution of hormone receptor markers. Correlation of BMI1 gene expression with oestrogen receptor, progesterone receptor (PR) and human epidermal growth factor receptor 2/neu status was analysed using Hex—protein docking tool. The hormone receptor expression was reduced with increasing grades of breast tumour. BMI1 gene expression was downregulated (real-time polymerase chain reaction analysis). Docking analysis explained the correlation between BMI1 and PR expression. BMI1 gene was co-regulated (down) with PR in the invasive ductal breast carcinoma with relative progression explicating it a diagnostic biomarker for ductal carcinoma of the breast.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>23873108</pmid><doi>10.1007/s13277-013-0965-y</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1010-4283 |
| ispartof | Tumor biology, 2013-12, Vol.34 (6), p.3807-3815 |
| issn | 1010-4283 1423-0380 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1534830523 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Female Gene expression Gene Expression Regulation, Neoplastic Histology Hormones Humans Immunohistochemistry Models, Molecular Murine leukemia virus Neoplasm Grading Polycomb Repressive Complex 1 - chemistry Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Protein Binding Protein Structure, Tertiary Proteins Receptor, ErbB-2 - chemistry Receptor, ErbB-2 - metabolism Receptors, Estrogen - chemistry Receptors, Estrogen - metabolism Receptors, Progesterone - chemistry Receptors, Progesterone - metabolism Research Article Reverse Transcriptase Polymerase Chain Reaction |
| title | Regulation of BMI1 Polycomb gene expression in histological grades of invasive ductal breast carcinomas and its correlation with hormone receptor status |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T23%3A49%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20BMI1%20Polycomb%20gene%20expression%20in%20histological%20grades%20of%20invasive%20ductal%20breast%20carcinomas%20and%20its%20correlation%20with%20hormone%20receptor%20status&rft.jtitle=Tumor%20biology&rft.au=Parvathi,%20M.%20V.%20S.&rft.date=2013-12-01&rft.volume=34&rft.issue=6&rft.spage=3807&rft.epage=3815&rft.pages=3807-3815&rft.issn=1010-4283&rft.eissn=1423-0380&rft_id=info:doi/10.1007/s13277-013-0965-y&rft_dat=%3Cproquest_cross%3E3152052841%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1466522810&rft_id=info:pmid/23873108&rfr_iscdi=true |