Topical application of polyethylenimine as a candidate for novel prophylactic therapeutics against genital herpes caused by herpes simplex virus

Herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) cause genital herpes, which can enhance the acquisition of human immunodeficiency virus. The development of anti-HSV agents with novel mechanisms of action is urgently required in the topical therapy of genital herpes. In this study, the in vitro an...

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Veröffentlicht in:	Archives of virology 2014-03, Vol.159 (3), p.425-435
Hauptverfasser:	Hayashi, Kyoko, Onoue, Hiroki, Sasaki, Kohei, Lee, Jung-Bum, Kumar, Penmetcha K. R, Gopinath, Subash C. B, Maitani, Yoshie, Kai, Takashi, Hayashi, Toshimitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Anti-Infective Agents, Local - pharmacology Anti-Infective Agents, Local - therapeutic use antiviral properties Biomedical and Life Sciences Biomedicine Cytotoxicity disease course Disease Models, Animal Female Glycoproteins Herpes Genitalis - prevention & control herpes simplex Herpes simplex virus 1 Herpes simplex virus 2 Herpes viruses Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - physiology Herpesvirus 2, Human - drug effects Herpesvirus 2, Human - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Human immunodeficiency virus 2 Infections Infectious Diseases Medical Microbiology Mice Mice, Inbred BALB C Microbial Sensitivity Tests Microbial Viability - drug effects Original Article Polyethyleneimine - pharmacology Polyethyleneimine - therapeutic use therapeutics topical application Treatment Outcome Virology Virus Internalization - drug effects viruses
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