Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene ( NR3C1 ) promoter region in cord blood
Abstract Background The methylation status of the human glucocorticoid receptor gene NR3C1 in newborns has been reported to be sensitive to prenatal maternal mood. This study investigates both the association between maternal cortisol and emotional state during pregnancy and the methylation state of...
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| Veröffentlicht in: | Journal of psychiatric research 2013-07, Vol.47 (7), p.880-891 |
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| creator | Hompes, Titia Izzi, Benedetta Gellens, Edith Morreels, Maarten Fieuws, Steffen Pexsters, Anne Schops, Ganel Dom, Myriam Van Bree, Rieta Freson, Kathleen Verhaeghe, Johan Spitz, Bernard Demyttenaere, Koen Glover, Vivette Van den Bergh, Bea Allegaert, Karel Claes, Stephan |
| description | Abstract Background The methylation status of the human glucocorticoid receptor gene NR3C1 in newborns has been reported to be sensitive to prenatal maternal mood. This study investigates both the association between maternal cortisol and emotional state during pregnancy and the methylation state of the promoter region of NR3C1 gene. Methods We examined 83 pregnant women. Psychological data and diurnal cortisol data were assessed to evaluate maternal stress once each trimester. DNA methylation at different loci of the NR3C1 gene, including exon 1B , 1D and 1F , was analyzed in genomic DNA from cord blood mononuclear cells. Results Univariable analyses indicated pregnancy related anxiety to be the strongest psychological parameter throughout pregnancy. Most significant findings concerned 1F . Particularly the methylation state of CpG9 was significantly associated with maternal emotional wellbeing. In a multivariable model the proportion of variance in methylation state of F9 explained (PVE) by pregnancy related anxiety was 7.8% ( p = 0.023) during T1. Furthermore different CpG-units located at the nerve growth factor inducible protein A (NGFI-A) binding sites of 1F were associated with maternal anxiety [(F20.21: PC PRAQ and fear of integrity in T1: respectively PVE:8.9% and PVE:9.0%; Fear of delivery T2: PVE:8.0%, Fear of integrity T2: PVE:6.0% and STAI T2: PVE:5.9%) – (F12.13: PC PRAQ T1: PVE:6.9%, fear of integrity T2: PVE:6.0% and fear of delivery T2: PVE:8.0%)] and cortisol (F38.39: PVE:8.9%) in T2. Conclusion These data indicate that prenatal maternal emotional state, particularly pregnancy related anxiety, are associated with the methylation state of the NR3C1 gene in the child. |
| doi_str_mv | 10.1016/j.jpsychires.2013.03.009 |
| format | Article |
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This study investigates both the association between maternal cortisol and emotional state during pregnancy and the methylation state of the promoter region of NR3C1 gene. Methods We examined 83 pregnant women. Psychological data and diurnal cortisol data were assessed to evaluate maternal stress once each trimester. DNA methylation at different loci of the NR3C1 gene, including exon 1B , 1D and 1F , was analyzed in genomic DNA from cord blood mononuclear cells. Results Univariable analyses indicated pregnancy related anxiety to be the strongest psychological parameter throughout pregnancy. Most significant findings concerned 1F . Particularly the methylation state of CpG9 was significantly associated with maternal emotional wellbeing. In a multivariable model the proportion of variance in methylation state of F9 explained (PVE) by pregnancy related anxiety was 7.8% ( p = 0.023) during T1. Furthermore different CpG-units located at the nerve growth factor inducible protein A (NGFI-A) binding sites of 1F were associated with maternal anxiety [(F20.21: PC PRAQ and fear of integrity in T1: respectively PVE:8.9% and PVE:9.0%; Fear of delivery T2: PVE:8.0%, Fear of integrity T2: PVE:6.0% and STAI T2: PVE:5.9%) – (F12.13: PC PRAQ T1: PVE:6.9%, fear of integrity T2: PVE:6.0% and fear of delivery T2: PVE:8.0%)] and cortisol (F38.39: PVE:8.9%) in T2. Conclusion These data indicate that prenatal maternal emotional state, particularly pregnancy related anxiety, are associated with the methylation state of the NR3C1 gene in the child.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2013.03.009</identifier><identifier>PMID: 23566423</identifier><identifier>CODEN: JPYRA3</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Anxiety ; Anxiety - blood ; Anxiety - genetics ; Anxiety - psychology ; Area Under Curve ; Biological and medical sciences ; Cord blood ; Cortisol ; CpG Islands - genetics ; DNA Methylation ; Emotions - physiology ; Epigenomics ; Europe ; Fear ; Female ; Fetal Blood - metabolism ; Genes ; Gestational Age ; Humans ; Hydrocortisone - metabolism ; Maternal anxiety ; Maternal HPA axis ; Maternal-Fetal Exchange - genetics ; Medical sciences ; Methylation state NR3C1 ; Pregnancy ; Pregnant women ; Prenatal maternal emotional wellbeing ; Promoter Regions, Genetic - genetics ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Receptors, Glucocorticoid - genetics ; Receptors, Glucocorticoid - metabolism ; Retrospective Studies ; Saliva - metabolism ; Surveys and Questionnaires</subject><ispartof>Journal of psychiatric research, 2013-07, Vol.47 (7), p.880-891</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c646t-3bac06c3b14c1ecabf3553abfe43078a672bd0dc1c400eaeabbb25229a7256a83</citedby><cites>FETCH-LOGICAL-c646t-3bac06c3b14c1ecabf3553abfe43078a672bd0dc1c400eaeabbb25229a7256a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpsychires.2013.03.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,31000,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27325251$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23566423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hompes, Titia</creatorcontrib><creatorcontrib>Izzi, Benedetta</creatorcontrib><creatorcontrib>Gellens, Edith</creatorcontrib><creatorcontrib>Morreels, Maarten</creatorcontrib><creatorcontrib>Fieuws, Steffen</creatorcontrib><creatorcontrib>Pexsters, Anne</creatorcontrib><creatorcontrib>Schops, Ganel</creatorcontrib><creatorcontrib>Dom, Myriam</creatorcontrib><creatorcontrib>Van Bree, Rieta</creatorcontrib><creatorcontrib>Freson, Kathleen</creatorcontrib><creatorcontrib>Verhaeghe, Johan</creatorcontrib><creatorcontrib>Spitz, Bernard</creatorcontrib><creatorcontrib>Demyttenaere, Koen</creatorcontrib><creatorcontrib>Glover, Vivette</creatorcontrib><creatorcontrib>Van den Bergh, Bea</creatorcontrib><creatorcontrib>Allegaert, Karel</creatorcontrib><creatorcontrib>Claes, Stephan</creatorcontrib><title>Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene ( NR3C1 ) promoter region in cord blood</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Abstract Background The methylation status of the human glucocorticoid receptor gene NR3C1 in newborns has been reported to be sensitive to prenatal maternal mood. This study investigates both the association between maternal cortisol and emotional state during pregnancy and the methylation state of the promoter region of NR3C1 gene. Methods We examined 83 pregnant women. Psychological data and diurnal cortisol data were assessed to evaluate maternal stress once each trimester. DNA methylation at different loci of the NR3C1 gene, including exon 1B , 1D and 1F , was analyzed in genomic DNA from cord blood mononuclear cells. Results Univariable analyses indicated pregnancy related anxiety to be the strongest psychological parameter throughout pregnancy. Most significant findings concerned 1F . Particularly the methylation state of CpG9 was significantly associated with maternal emotional wellbeing. In a multivariable model the proportion of variance in methylation state of F9 explained (PVE) by pregnancy related anxiety was 7.8% ( p = 0.023) during T1. Furthermore different CpG-units located at the nerve growth factor inducible protein A (NGFI-A) binding sites of 1F were associated with maternal anxiety [(F20.21: PC PRAQ and fear of integrity in T1: respectively PVE:8.9% and PVE:9.0%; Fear of delivery T2: PVE:8.0%, Fear of integrity T2: PVE:6.0% and STAI T2: PVE:5.9%) – (F12.13: PC PRAQ T1: PVE:6.9%, fear of integrity T2: PVE:6.0% and fear of delivery T2: PVE:8.0%)] and cortisol (F38.39: PVE:8.9%) in T2. Conclusion These data indicate that prenatal maternal emotional state, particularly pregnancy related anxiety, are associated with the methylation state of the NR3C1 gene in the child.</description><subject>Adult</subject><subject>Anxiety</subject><subject>Anxiety - blood</subject><subject>Anxiety - genetics</subject><subject>Anxiety - psychology</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Cord blood</subject><subject>Cortisol</subject><subject>CpG Islands - genetics</subject><subject>DNA Methylation</subject><subject>Emotions - physiology</subject><subject>Epigenomics</subject><subject>Europe</subject><subject>Fear</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Genes</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Hydrocortisone - metabolism</subject><subject>Maternal anxiety</subject><subject>Maternal HPA axis</subject><subject>Maternal-Fetal Exchange - genetics</subject><subject>Medical sciences</subject><subject>Methylation state NR3C1</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Prenatal maternal emotional wellbeing</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Receptors, Glucocorticoid - genetics</subject><subject>Receptors, Glucocorticoid - metabolism</subject><subject>Retrospective Studies</subject><subject>Saliva - metabolism</subject><subject>Surveys and Questionnaires</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkl2L1DAUhoso7rj6FyQ3wnoxYz7atL0R1vFrYVnBj-uQpqedjGkyJunC_Dr_msnM6II3uxAIJE_e9-SctygQwSuCCX-zXW13Ya822kNYUUzYCqeF20fFgjR1uySsbh8XC4wpXbK24mfFsxC2GOOakvJpcUZZxXlJ2aL4fWVvIUQ9yqjtiOIGkLaDmcEqQG5Ak4zgrTRIOR91cAZJ2yOYXNQuH4eYANTPPr_eeRittGqPnD1Ivb-5RBPEzd7IzB_oOWTdfDuaWbmDrnK6Rx4U7KLzaAQL6ALdfGVrgl4nVZfswCdgzCLa5mJ61Bnn-ufFk0GaAC9O-3nx4-OH7-vPy-svn67Wl9dLxUsel6yTCnPFOlIqAkp2A6sqljYoGa4byWva9bhXRJUYgwTZdR2tKG1lTSsuG3ZeXBx1UzW_5tQxMemgwBhpwc1BkIqVDW1Yyx-AYtykmRF6P1qSuiqbNNL7UVZTXPGqzKrNEVXeheBhEDuvJ-n3gmCR8yO24i4_IudH4LRwdnl5cpm7Cfp_D_8GJgGvToAMSprBp3HrcMfVLLWtIol7d-QgDeVWgxdB6RyqPnmqKHqnH1LN2_9ElNFWJ9-fsIewdXOOZvq7CFRg8S3nPcedsBT1NtXyB17vAKw</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Hompes, Titia</creator><creator>Izzi, Benedetta</creator><creator>Gellens, Edith</creator><creator>Morreels, Maarten</creator><creator>Fieuws, Steffen</creator><creator>Pexsters, Anne</creator><creator>Schops, Ganel</creator><creator>Dom, Myriam</creator><creator>Van Bree, Rieta</creator><creator>Freson, Kathleen</creator><creator>Verhaeghe, Johan</creator><creator>Spitz, Bernard</creator><creator>Demyttenaere, Koen</creator><creator>Glover, Vivette</creator><creator>Van den Bergh, Bea</creator><creator>Allegaert, Karel</creator><creator>Claes, Stephan</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7QJ</scope></search><sort><creationdate>20130701</creationdate><title>Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene ( NR3C1 ) promoter region in cord blood</title><author>Hompes, Titia ; Izzi, Benedetta ; Gellens, Edith ; Morreels, Maarten ; Fieuws, Steffen ; Pexsters, Anne ; Schops, Ganel ; Dom, Myriam ; Van Bree, Rieta ; Freson, Kathleen ; Verhaeghe, Johan ; Spitz, Bernard ; Demyttenaere, Koen ; Glover, Vivette ; Van den Bergh, Bea ; Allegaert, Karel ; Claes, Stephan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c646t-3bac06c3b14c1ecabf3553abfe43078a672bd0dc1c400eaeabbb25229a7256a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Anxiety</topic><topic>Anxiety - blood</topic><topic>Anxiety - genetics</topic><topic>Anxiety - psychology</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Cord blood</topic><topic>Cortisol</topic><topic>CpG Islands - genetics</topic><topic>DNA Methylation</topic><topic>Emotions - physiology</topic><topic>Epigenomics</topic><topic>Europe</topic><topic>Fear</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Genes</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Hydrocortisone - metabolism</topic><topic>Maternal anxiety</topic><topic>Maternal HPA axis</topic><topic>Maternal-Fetal Exchange - genetics</topic><topic>Medical sciences</topic><topic>Methylation state NR3C1</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>Prenatal maternal emotional wellbeing</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Receptors, Glucocorticoid - genetics</topic><topic>Receptors, Glucocorticoid - metabolism</topic><topic>Retrospective Studies</topic><topic>Saliva - metabolism</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hompes, Titia</creatorcontrib><creatorcontrib>Izzi, Benedetta</creatorcontrib><creatorcontrib>Gellens, Edith</creatorcontrib><creatorcontrib>Morreels, Maarten</creatorcontrib><creatorcontrib>Fieuws, Steffen</creatorcontrib><creatorcontrib>Pexsters, Anne</creatorcontrib><creatorcontrib>Schops, Ganel</creatorcontrib><creatorcontrib>Dom, Myriam</creatorcontrib><creatorcontrib>Van Bree, Rieta</creatorcontrib><creatorcontrib>Freson, Kathleen</creatorcontrib><creatorcontrib>Verhaeghe, Johan</creatorcontrib><creatorcontrib>Spitz, Bernard</creatorcontrib><creatorcontrib>Demyttenaere, Koen</creatorcontrib><creatorcontrib>Glover, Vivette</creatorcontrib><creatorcontrib>Van den Bergh, Bea</creatorcontrib><creatorcontrib>Allegaert, Karel</creatorcontrib><creatorcontrib>Claes, Stephan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hompes, Titia</au><au>Izzi, Benedetta</au><au>Gellens, Edith</au><au>Morreels, Maarten</au><au>Fieuws, Steffen</au><au>Pexsters, Anne</au><au>Schops, Ganel</au><au>Dom, Myriam</au><au>Van Bree, Rieta</au><au>Freson, Kathleen</au><au>Verhaeghe, Johan</au><au>Spitz, Bernard</au><au>Demyttenaere, Koen</au><au>Glover, Vivette</au><au>Van den Bergh, Bea</au><au>Allegaert, Karel</au><au>Claes, Stephan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene ( NR3C1 ) promoter region in cord blood</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>47</volume><issue>7</issue><spage>880</spage><epage>891</epage><pages>880-891</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><coden>JPYRA3</coden><abstract>Abstract Background The methylation status of the human glucocorticoid receptor gene NR3C1 in newborns has been reported to be sensitive to prenatal maternal mood. This study investigates both the association between maternal cortisol and emotional state during pregnancy and the methylation state of the promoter region of NR3C1 gene. Methods We examined 83 pregnant women. Psychological data and diurnal cortisol data were assessed to evaluate maternal stress once each trimester. DNA methylation at different loci of the NR3C1 gene, including exon 1B , 1D and 1F , was analyzed in genomic DNA from cord blood mononuclear cells. Results Univariable analyses indicated pregnancy related anxiety to be the strongest psychological parameter throughout pregnancy. Most significant findings concerned 1F . Particularly the methylation state of CpG9 was significantly associated with maternal emotional wellbeing. In a multivariable model the proportion of variance in methylation state of F9 explained (PVE) by pregnancy related anxiety was 7.8% ( p = 0.023) during T1. Furthermore different CpG-units located at the nerve growth factor inducible protein A (NGFI-A) binding sites of 1F were associated with maternal anxiety [(F20.21: PC PRAQ and fear of integrity in T1: respectively PVE:8.9% and PVE:9.0%; Fear of delivery T2: PVE:8.0%, Fear of integrity T2: PVE:6.0% and STAI T2: PVE:5.9%) – (F12.13: PC PRAQ T1: PVE:6.9%, fear of integrity T2: PVE:6.0% and fear of delivery T2: PVE:8.0%)] and cortisol (F38.39: PVE:8.9%) in T2. Conclusion These data indicate that prenatal maternal emotional state, particularly pregnancy related anxiety, are associated with the methylation state of the NR3C1 gene in the child.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>23566423</pmid><doi>10.1016/j.jpsychires.2013.03.009</doi><tpages>12</tpages></addata></record> |
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| subjects | Adult Anxiety Anxiety - blood Anxiety - genetics Anxiety - psychology Area Under Curve Biological and medical sciences Cord blood Cortisol CpG Islands - genetics DNA Methylation Emotions - physiology Epigenomics Europe Fear Female Fetal Blood - metabolism Genes Gestational Age Humans Hydrocortisone - metabolism Maternal anxiety Maternal HPA axis Maternal-Fetal Exchange - genetics Medical sciences Methylation state NR3C1 Pregnancy Pregnant women Prenatal maternal emotional wellbeing Promoter Regions, Genetic - genetics Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Retrospective Studies Saliva - metabolism Surveys and Questionnaires |
| title | Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene ( NR3C1 ) promoter region in cord blood |
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