Uptake of O-(2-[18 F]fluoroethyl)- L -tyrosine in reactive astrocytosis in the vicinity of cerebral gliomas

Abstract PET using O-(2-[18 F]fluoroethyl)- L -tyrosine (18 F-FET) allows improved imaging of tumor extent of cerebral gliomas in comparison to MRI. In experimental brain infarction and hematoma, an unspecific accumulation of18 F-FET has been detected in the area of reactive astrogliosis which is a...

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Veröffentlicht in:	Nuclear medicine and biology 2013-08, Vol.40 (6), p.795-800
Hauptverfasser:	Piroth, Marc D, Prasath, Jeyakamalini, Willuweit, Antje, Stoffels, Gabriele, Sellhaus, Bernd, van Osterhout, Ansel, Geisler, Stefanie, Shah, Nadim J, Eble, Michael J, Coenen, Heinz H, Langen, Karl-Josef
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrogliosis Autoradiography Biological Transport Brain - diagnostic imaging Brain - metabolism Brain Neoplasms - complications Brain Neoplasms - radiotherapy Cell Line, Tumor Cerebral glioma False Positive Reactions Glioma - complications Glioma - radiotherapy Gliosis - complications Gliosis - diagnostic imaging Gliosis - metabolism Male O-(2-[18F]fluoroethyl)-L-tyrosine PET Positron-Emission Tomography Radiology Rats Tyrosine - analogs & derivatives Tyrosine - metabolism
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