The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol

Arimoclomol is a hydroxylamine derivative, a group of compounds which have unique properties as co-inducers of heat shock protein expression, but only under conditions of cellular stress. Arimoclomol has been found to be neuroprotective in a number of neurodegenerative disease models, including Amyo...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2014, Vol.141 (1), p.40-54
Hauptverfasser:	KALMAR, Bernadett, LU, Ching-Hua, GREENSMITH, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis - drug therapy Amyotrophic Lateral Sclerosis - metabolism Animals Biological and medical sciences Cerebrospinal fluid. Meninges. Spinal cord Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Endoplasmic Reticulum Chaperone BiP Enzyme Induction - drug effects Heat-Shock Proteins - biosynthesis Heat-Shock Proteins - drug effects Heat-Shock Proteins - metabolism Heat-Shock Response - drug effects Humans Hydroxylamines - pharmacology Hydroxylamines - therapeutic use Medical sciences Models, Biological Molecular Targeted Therapy - methods Nervous system (semeiology, syndromes) Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use
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