Disrupted anatomic white matter network in left mesial temporal lobe epilepsy
Summary Objective Brain imaging studies have shown widespread structural abnormalities in patients with temporal lobe epilepsy (TLE) within and beyond the affected temporal lobe, suggesting an altered network. Graph theoretical analysis based on white matter tractography has provided a new perspecti...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2014-05, Vol.55 (5), p.674-682 |
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| container_title | Epilepsia (Copenhagen) |
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| creator | Liu, Min Chen, Zhang Beaulieu, Christian Gross, Donald W. |
| description | Summary
Objective
Brain imaging studies have shown widespread structural abnormalities in patients with temporal lobe epilepsy (TLE) within and beyond the affected temporal lobe, suggesting an altered network. Graph theoretical analysis based on white matter tractography has provided a new perspective to evaluate the connectivity of the brain. The alterations in the topologic properties of a whole brain white matter network in patients with TLE remain unknown. The purpose of this study was to examine the white matter network in a cohort of patients with left TLE and mesial temporal sclerosis (mTLE) compared to healthy controls.
Methods
Anatomic brain networks of 16 patients with left mTLE were compared to those of 21 healthy controls. A white matter structural network was constructed from diffusion tensor tractography for each participant, and network parameters were compared between the patient and control groups.
Results
Patients with left mTLE exhibited concurrent decreases of global and local efficiencies and widespread reduction of regional efficiency in ipsilateral temporal, bilateral frontal, and bilateral parietal areas. Communication hubs, such as the left precuneus, were also altered in patients with mTLE compared to controls.
Significance
Our results demonstrate white matter network disruption in patients with left mTLE, supporting the notion that mTLE is a systemic brain disorder.
A PowerPoint slide summarizing this article is available for download in the Supporting Information section here. |
| doi_str_mv | 10.1111/epi.12581 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1534826962</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1527329853</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4871-538689bed269656356d36970ab84f057ea803894a2345e0e25220d8f9199b1983</originalsourceid><addsrcrecordid>eNqN0ctKAzEUBuAgiq3VhS8gATe6mDaXSSZZSq1aqOhC10Omcwanzs0kQ-nbm9rqQhDM5mTx8ZP8B6FzSsY0nAl05ZgyoegBGlLBVESpTA7RkBDKIy0UGaAT51aEkEQm_BgNWCwFCWaIHm9LZ_vOQ45NY3xbl0u8fis94Np4DxY34NetfcdlgysoPK7BlabCHuquteFStRng8IAKOrc5RUeFqRyc7ecIvd7NXqYP0eLpfj69WUTLWCU0ElxJpTPImdRSSC5kzqVOiMlUXBCRgFGEKx0bxmMBBJhgjOSq0FTrjGrFR-hql9vZ9qMH59O6dEuoKtNA27uUCh6rbTj7B2UJZ1oJHujlL7pqe9uEj2yVDO3xwEboeqeWtnXOQpF2tqyN3aSUpNt1pKGN9GsdwV7sE_ushvxHfvcfwGQH1qHAzd9J6ex5vov8BJ6kkR0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1526007385</pqid></control><display><type>article</type><title>Disrupted anatomic white matter network in left mesial temporal lobe epilepsy</title><source>Wiley Free Content</source><source>MEDLINE</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Liu, Min ; Chen, Zhang ; Beaulieu, Christian ; Gross, Donald W.</creator><creatorcontrib>Liu, Min ; Chen, Zhang ; Beaulieu, Christian ; Gross, Donald W.</creatorcontrib><description>Summary
Objective
Brain imaging studies have shown widespread structural abnormalities in patients with temporal lobe epilepsy (TLE) within and beyond the affected temporal lobe, suggesting an altered network. Graph theoretical analysis based on white matter tractography has provided a new perspective to evaluate the connectivity of the brain. The alterations in the topologic properties of a whole brain white matter network in patients with TLE remain unknown. The purpose of this study was to examine the white matter network in a cohort of patients with left TLE and mesial temporal sclerosis (mTLE) compared to healthy controls.
Methods
Anatomic brain networks of 16 patients with left mTLE were compared to those of 21 healthy controls. A white matter structural network was constructed from diffusion tensor tractography for each participant, and network parameters were compared between the patient and control groups.
Results
Patients with left mTLE exhibited concurrent decreases of global and local efficiencies and widespread reduction of regional efficiency in ipsilateral temporal, bilateral frontal, and bilateral parietal areas. Communication hubs, such as the left precuneus, were also altered in patients with mTLE compared to controls.
Significance
Our results demonstrate white matter network disruption in patients with left mTLE, supporting the notion that mTLE is a systemic brain disorder.
A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/epi.12581</identifier><identifier>PMID: 24650167</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Brain ; Brain - pathology ; Brain - physiopathology ; Cerebral Cortex - pathology ; Cerebral Cortex - physiopathology ; Diffusion Magnetic Resonance Imaging ; Diffusion tensor imaging ; Dominance, Cerebral - physiology ; Epilepsy, Temporal Lobe - diagnosis ; Epilepsy, Temporal Lobe - pathology ; Epilepsy, Temporal Lobe - physiopathology ; Female ; Graph theory ; Hippocampus - pathology ; Hippocampus - physiopathology ; Humans ; Image Enhancement ; Image Interpretation, Computer-Assisted ; Leukoencephalopathies - diagnosis ; Leukoencephalopathies - pathology ; Leukoencephalopathies - physiopathology ; Male ; Medical research ; Middle Aged ; Nerve Net - pathology ; Nerve Net - physiopathology ; Network ; Neuropsychological Tests ; Sclerosis ; Temporal Lobe - pathology ; Temporal Lobe - physiopathology ; Temporal lobe epilepsy ; Tractography ; Young Adult</subject><ispartof>Epilepsia (Copenhagen), 2014-05, Vol.55 (5), p.674-682</ispartof><rights>Wiley Periodicals, Inc. © 2014 International League Against Epilepsy</rights><rights>Wiley Periodicals, Inc. © 2014 International League Against Epilepsy.</rights><rights>Copyright © 2014 International League Against Epilepsy</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4871-538689bed269656356d36970ab84f057ea803894a2345e0e25220d8f9199b1983</citedby><cites>FETCH-LOGICAL-c4871-538689bed269656356d36970ab84f057ea803894a2345e0e25220d8f9199b1983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fepi.12581$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fepi.12581$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24650167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Min</creatorcontrib><creatorcontrib>Chen, Zhang</creatorcontrib><creatorcontrib>Beaulieu, Christian</creatorcontrib><creatorcontrib>Gross, Donald W.</creatorcontrib><title>Disrupted anatomic white matter network in left mesial temporal lobe epilepsy</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Objective
Brain imaging studies have shown widespread structural abnormalities in patients with temporal lobe epilepsy (TLE) within and beyond the affected temporal lobe, suggesting an altered network. Graph theoretical analysis based on white matter tractography has provided a new perspective to evaluate the connectivity of the brain. The alterations in the topologic properties of a whole brain white matter network in patients with TLE remain unknown. The purpose of this study was to examine the white matter network in a cohort of patients with left TLE and mesial temporal sclerosis (mTLE) compared to healthy controls.
Methods
Anatomic brain networks of 16 patients with left mTLE were compared to those of 21 healthy controls. A white matter structural network was constructed from diffusion tensor tractography for each participant, and network parameters were compared between the patient and control groups.
Results
Patients with left mTLE exhibited concurrent decreases of global and local efficiencies and widespread reduction of regional efficiency in ipsilateral temporal, bilateral frontal, and bilateral parietal areas. Communication hubs, such as the left precuneus, were also altered in patients with mTLE compared to controls.
Significance
Our results demonstrate white matter network disruption in patients with left mTLE, supporting the notion that mTLE is a systemic brain disorder.
A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.</description><subject>Adult</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Diffusion tensor imaging</subject><subject>Dominance, Cerebral - physiology</subject><subject>Epilepsy, Temporal Lobe - diagnosis</subject><subject>Epilepsy, Temporal Lobe - pathology</subject><subject>Epilepsy, Temporal Lobe - physiopathology</subject><subject>Female</subject><subject>Graph theory</subject><subject>Hippocampus - pathology</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Image Enhancement</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Leukoencephalopathies - diagnosis</subject><subject>Leukoencephalopathies - pathology</subject><subject>Leukoencephalopathies - physiopathology</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Nerve Net - pathology</subject><subject>Nerve Net - physiopathology</subject><subject>Network</subject><subject>Neuropsychological Tests</subject><subject>Sclerosis</subject><subject>Temporal Lobe - pathology</subject><subject>Temporal Lobe - physiopathology</subject><subject>Temporal lobe epilepsy</subject><subject>Tractography</subject><subject>Young Adult</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0ctKAzEUBuAgiq3VhS8gATe6mDaXSSZZSq1aqOhC10Omcwanzs0kQ-nbm9rqQhDM5mTx8ZP8B6FzSsY0nAl05ZgyoegBGlLBVESpTA7RkBDKIy0UGaAT51aEkEQm_BgNWCwFCWaIHm9LZ_vOQ45NY3xbl0u8fis94Np4DxY34NetfcdlgysoPK7BlabCHuquteFStRng8IAKOrc5RUeFqRyc7ecIvd7NXqYP0eLpfj69WUTLWCU0ElxJpTPImdRSSC5kzqVOiMlUXBCRgFGEKx0bxmMBBJhgjOSq0FTrjGrFR-hql9vZ9qMH59O6dEuoKtNA27uUCh6rbTj7B2UJZ1oJHujlL7pqe9uEj2yVDO3xwEboeqeWtnXOQpF2tqyN3aSUpNt1pKGN9GsdwV7sE_ushvxHfvcfwGQH1qHAzd9J6ex5vov8BJ6kkR0</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Liu, Min</creator><creator>Chen, Zhang</creator><creator>Beaulieu, Christian</creator><creator>Gross, Donald W.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>Disrupted anatomic white matter network in left mesial temporal lobe epilepsy</title><author>Liu, Min ; Chen, Zhang ; Beaulieu, Christian ; Gross, Donald W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4871-538689bed269656356d36970ab84f057ea803894a2345e0e25220d8f9199b1983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Brain</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Cerebral Cortex - pathology</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Diffusion tensor imaging</topic><topic>Dominance, Cerebral - physiology</topic><topic>Epilepsy, Temporal Lobe - diagnosis</topic><topic>Epilepsy, Temporal Lobe - pathology</topic><topic>Epilepsy, Temporal Lobe - physiopathology</topic><topic>Female</topic><topic>Graph theory</topic><topic>Hippocampus - pathology</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Image Enhancement</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Leukoencephalopathies - diagnosis</topic><topic>Leukoencephalopathies - pathology</topic><topic>Leukoencephalopathies - physiopathology</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Nerve Net - pathology</topic><topic>Nerve Net - physiopathology</topic><topic>Network</topic><topic>Neuropsychological Tests</topic><topic>Sclerosis</topic><topic>Temporal Lobe - pathology</topic><topic>Temporal Lobe - physiopathology</topic><topic>Temporal lobe epilepsy</topic><topic>Tractography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Min</creatorcontrib><creatorcontrib>Chen, Zhang</creatorcontrib><creatorcontrib>Beaulieu, Christian</creatorcontrib><creatorcontrib>Gross, Donald W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Min</au><au>Chen, Zhang</au><au>Beaulieu, Christian</au><au>Gross, Donald W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disrupted anatomic white matter network in left mesial temporal lobe epilepsy</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2014-05</date><risdate>2014</risdate><volume>55</volume><issue>5</issue><spage>674</spage><epage>682</epage><pages>674-682</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary
Objective
Brain imaging studies have shown widespread structural abnormalities in patients with temporal lobe epilepsy (TLE) within and beyond the affected temporal lobe, suggesting an altered network. Graph theoretical analysis based on white matter tractography has provided a new perspective to evaluate the connectivity of the brain. The alterations in the topologic properties of a whole brain white matter network in patients with TLE remain unknown. The purpose of this study was to examine the white matter network in a cohort of patients with left TLE and mesial temporal sclerosis (mTLE) compared to healthy controls.
Methods
Anatomic brain networks of 16 patients with left mTLE were compared to those of 21 healthy controls. A white matter structural network was constructed from diffusion tensor tractography for each participant, and network parameters were compared between the patient and control groups.
Results
Patients with left mTLE exhibited concurrent decreases of global and local efficiencies and widespread reduction of regional efficiency in ipsilateral temporal, bilateral frontal, and bilateral parietal areas. Communication hubs, such as the left precuneus, were also altered in patients with mTLE compared to controls.
Significance
Our results demonstrate white matter network disruption in patients with left mTLE, supporting the notion that mTLE is a systemic brain disorder.
A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24650167</pmid><doi>10.1111/epi.12581</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Brain Brain - pathology Brain - physiopathology Cerebral Cortex - pathology Cerebral Cortex - physiopathology Diffusion Magnetic Resonance Imaging Diffusion tensor imaging Dominance, Cerebral - physiology Epilepsy, Temporal Lobe - diagnosis Epilepsy, Temporal Lobe - pathology Epilepsy, Temporal Lobe - physiopathology Female Graph theory Hippocampus - pathology Hippocampus - physiopathology Humans Image Enhancement Image Interpretation, Computer-Assisted Leukoencephalopathies - diagnosis Leukoencephalopathies - pathology Leukoencephalopathies - physiopathology Male Medical research Middle Aged Nerve Net - pathology Nerve Net - physiopathology Network Neuropsychological Tests Sclerosis Temporal Lobe - pathology Temporal Lobe - physiopathology Temporal lobe epilepsy Tractography Young Adult |
| title | Disrupted anatomic white matter network in left mesial temporal lobe epilepsy |
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