Role of the Lipid Peroxidation Product, 4‑Hydroxynonenal, in the Development of Nitrate Tolerance

Tolerance to nitrates such as nitroglycerin (GTN) is associated with oxidative stress, inactivation of aldehyde dehydrogenase 2 (ALDH2), and decreased GTN-induced cGMP accumulation and vasodilation. We hypothesized that GTN-induced inactivation of ALDH2 results in increased 4-hydroxy-2-nonenal (HNE)...

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Veröffentlicht in:	Chemical research in toxicology 2014-04, Vol.27 (4), p.663-673
Hauptverfasser:	D’Souza, Yohan, Kawamoto, Toshihiro, Bennett, Brian M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Dehydrogenase - metabolism Aldehydes - chemistry Animals Drug Tolerance Lipid Peroxidation LLC-PK1 Cells Male Mice Mice, Inbred C57BL Mitochondria, Liver - enzymology Nitrates - pharmacology Rats Rats, Sprague-Dawley Swine Vasodilation
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