Efficacy of Early Intravenous Immunoglobulin for Eosinophilic Granulomatosis with Polyangiitis with Drastically Progressive Neuropathy: A Synopsis of Two Cases
Two women, 66-year-old and 63-year-old, were admitted for drastically progressive neuropathy, and diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA). Steroid pulse therapy failed to exert effect upon neuropathy, so we administered early intravenous immunoglobulin (IVIG) for fear of...
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| Veröffentlicht in: | Internal Medicine 2013, Vol.52(8), pp.913-917 |
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| container_title | Internal Medicine |
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| creator | Matsumoto, Takeshi Otsuka, Kojiro Kawamoto, Michi Nagata, Kazuma Tachikawa, Ryo Imai, Yukihiro Oka, Nobuyuki Tomii, Keisuke |
| description | Two women, 66-year-old and 63-year-old, were admitted for drastically progressive neuropathy, and diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA). Steroid pulse therapy failed to exert effect upon neuropathy, so we administered early intravenous immunoglobulin (IVIG) for fear of immobilization of neuropathy. This resulted in marked improvement in neuropathy without apparent side effects. Recent evidence suggests the efficacy of IVIG for steroid refractory neuropathy associated with EGPA, but has previously been administered during the chronic phase resulting in slow improvement. Our two successfully treated cases indicate the efficacy of early IVIG in preventing the immobilization of neuropathy, especially in progressive cases. |
| doi_str_mv | 10.2169/internalmedicine.52.8889 |
| format | Article |
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Steroid pulse therapy failed to exert effect upon neuropathy, so we administered early intravenous immunoglobulin (IVIG) for fear of immobilization of neuropathy. This resulted in marked improvement in neuropathy without apparent side effects. Recent evidence suggests the efficacy of IVIG for steroid refractory neuropathy associated with EGPA, but has previously been administered during the chronic phase resulting in slow improvement. Our two successfully treated cases indicate the efficacy of early IVIG in preventing the immobilization of neuropathy, especially in progressive cases.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.52.8889</identifier><identifier>PMID: 23583996</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aged ; Churg-Strauss syndrome (CSS) ; Disease Progression ; early administration ; Eosinophilic Granuloma - complications ; Eosinophilic Granuloma - diagnosis ; Eosinophilic Granuloma - drug therapy ; eosinophilic granulomatosis with polyangiitis (EGPA) ; Female ; Humans ; Immunoglobulins, Intravenous - administration & dosage ; Immunoglobulins, Intravenous - therapeutic use ; intravenous immunoglobulin (IVIG) ; Microscopic Polyangiitis - complications ; Microscopic Polyangiitis - diagnosis ; Microscopic Polyangiitis - drug therapy ; Middle Aged ; Neural Conduction - drug effects ; Neural Conduction - physiology ; Neuralgia - complications ; Neuralgia - diagnosis ; Neuralgia - drug therapy ; neuropathy ; Time Factors ; Treatment Outcome</subject><ispartof>Internal Medicine, 2013, Vol.52(8), pp.913-917</ispartof><rights>2013 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-4f71c5119fe98add88da6729a33433b266562afb751960e2ea729c18fbef13db3</citedby><cites>FETCH-LOGICAL-c559t-4f71c5119fe98add88da6729a33433b266562afb751960e2ea729c18fbef13db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23583996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, Takeshi</creatorcontrib><creatorcontrib>Otsuka, Kojiro</creatorcontrib><creatorcontrib>Kawamoto, Michi</creatorcontrib><creatorcontrib>Nagata, Kazuma</creatorcontrib><creatorcontrib>Tachikawa, Ryo</creatorcontrib><creatorcontrib>Imai, Yukihiro</creatorcontrib><creatorcontrib>Oka, Nobuyuki</creatorcontrib><creatorcontrib>Tomii, Keisuke</creatorcontrib><title>Efficacy of Early Intravenous Immunoglobulin for Eosinophilic Granulomatosis with Polyangiitis with Drastically Progressive Neuropathy: A Synopsis of Two Cases</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Two women, 66-year-old and 63-year-old, were admitted for drastically progressive neuropathy, and diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA). Steroid pulse therapy failed to exert effect upon neuropathy, so we administered early intravenous immunoglobulin (IVIG) for fear of immobilization of neuropathy. This resulted in marked improvement in neuropathy without apparent side effects. Recent evidence suggests the efficacy of IVIG for steroid refractory neuropathy associated with EGPA, but has previously been administered during the chronic phase resulting in slow improvement. Our two successfully treated cases indicate the efficacy of early IVIG in preventing the immobilization of neuropathy, especially in progressive cases.</description><subject>Aged</subject><subject>Churg-Strauss syndrome (CSS)</subject><subject>Disease Progression</subject><subject>early administration</subject><subject>Eosinophilic Granuloma - complications</subject><subject>Eosinophilic Granuloma - diagnosis</subject><subject>Eosinophilic Granuloma - drug therapy</subject><subject>eosinophilic granulomatosis with polyangiitis (EGPA)</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulins, Intravenous - administration & dosage</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>intravenous immunoglobulin (IVIG)</subject><subject>Microscopic Polyangiitis - complications</subject><subject>Microscopic Polyangiitis - diagnosis</subject><subject>Microscopic Polyangiitis - drug therapy</subject><subject>Middle Aged</subject><subject>Neural Conduction - drug effects</subject><subject>Neural Conduction - physiology</subject><subject>Neuralgia - complications</subject><subject>Neuralgia - diagnosis</subject><subject>Neuralgia - drug therapy</subject><subject>neuropathy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFr2zAQx8XYWLNuX2HocS_OLCm2pb2VLO0CpSusezZnWUpUZCmT5BZ_mn3VySTNwxgMxAnufve_4_4IYVIuKanFZ-OSCg7soHojjVPLii455-IVWhC2EkVDWfUaLUpBeEFzuEDvYnwsS8YbQd-ii1zmTIh6gX5vtDYS5IS9xhsIdsJblwI8KefHiLfDMDq_s74brXFY-4A3PhrnD3tjjcQ3Adxo_QApZyN-NmmP772dwO2MSS-ZrwFiylNsVr8PfhdUjOZJ4Ts1Bn-AtJ--4Cv8Y8qys0re5OHZ4zVEFd-jNxpsVB9O_yX6eb15WH8rbr_fbNdXt4WsKpGKlW6IrAgRWgkOfc95D3VDBTC2YqyjdV3VFHTXVETUpaIKclESrjulCes7dok-HXUPwf8aVUztYKJU1oJT-RAtqdiK0zK__6OMNg1tSD2j_IjK4GMMSreHYAYIU0vKdnay_dvJtqLt7GRu_XiaMna5eG58sS4Dd0fgMSbYqTMAIZ_aqn8rz-E04QzKPYRWOfYHlarAxg</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Matsumoto, Takeshi</creator><creator>Otsuka, Kojiro</creator><creator>Kawamoto, Michi</creator><creator>Nagata, Kazuma</creator><creator>Tachikawa, Ryo</creator><creator>Imai, Yukihiro</creator><creator>Oka, Nobuyuki</creator><creator>Tomii, Keisuke</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>20130101</creationdate><title>Efficacy of Early Intravenous Immunoglobulin for Eosinophilic Granulomatosis with Polyangiitis with Drastically Progressive Neuropathy: A Synopsis of Two Cases</title><author>Matsumoto, Takeshi ; 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Med.</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>52</volume><issue>8</issue><spage>913</spage><epage>917</epage><pages>913-917</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Two women, 66-year-old and 63-year-old, were admitted for drastically progressive neuropathy, and diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA). Steroid pulse therapy failed to exert effect upon neuropathy, so we administered early intravenous immunoglobulin (IVIG) for fear of immobilization of neuropathy. This resulted in marked improvement in neuropathy without apparent side effects. Recent evidence suggests the efficacy of IVIG for steroid refractory neuropathy associated with EGPA, but has previously been administered during the chronic phase resulting in slow improvement. 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| subjects | Aged Churg-Strauss syndrome (CSS) Disease Progression early administration Eosinophilic Granuloma - complications Eosinophilic Granuloma - diagnosis Eosinophilic Granuloma - drug therapy eosinophilic granulomatosis with polyangiitis (EGPA) Female Humans Immunoglobulins, Intravenous - administration & dosage Immunoglobulins, Intravenous - therapeutic use intravenous immunoglobulin (IVIG) Microscopic Polyangiitis - complications Microscopic Polyangiitis - diagnosis Microscopic Polyangiitis - drug therapy Middle Aged Neural Conduction - drug effects Neural Conduction - physiology Neuralgia - complications Neuralgia - diagnosis Neuralgia - drug therapy neuropathy Time Factors Treatment Outcome |
| title | Efficacy of Early Intravenous Immunoglobulin for Eosinophilic Granulomatosis with Polyangiitis with Drastically Progressive Neuropathy: A Synopsis of Two Cases |
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