The role of cigarette smoking and liver enzymes polymorphisms in anti-tuberculosis drug-induced hepatotoxicity in Brazilian patients

Summary Tuberculosis (TB) is still a major health concern and side-effects related to the treatment, especially drug-induced hepatotoxicity (DIH), should be better investigated. In the present study, a possible association between anti-TB DIH and cigarette smoking, N-acetyltransferase 2 ( NAT2 ), Cy...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2014-05, Vol.94 (3), p.299-305
Hauptverfasser:	Zaverucha-do-Valle, Camila, Monteiro, Sérgio P, El-Jaick, Kênia B, Rosadas, Leonardo A, Costa, Marli J.M, Quintana, Marcel S.B, de Castro, Liane
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antitubercular Agents - adverse effects Arylamine N-Acetyltransferase - genetics Case-Control Studies Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - genetics Cytochrome P-450 CYP2E1 - genetics Cytochrome P-450 CYP3A - genetics Female Genetic Predisposition to Disease - genetics Heterozygote Homozygote Humans Infectious Disease Male Mycobacterium Phenotype Polymerase Chain Reaction Polymorphism, Genetic - genetics Polymorphism, Restriction Fragment Length Pulmonary/Respiratory Retrospective Studies Risk Factors Smoking - genetics Tuberculosis - drug therapy Tuberculosis - enzymology Tuberculosis - genetics
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