Bruton tyrosine kinase mediates TLR9 -dependent human dendritic cell activation

Background Bruton tyrosine kinase (BTK) plays an essential role in various biologic functions of different cell types. Mutations in BTK lead to X-linked agammaglobulinemia (XLA) in humans. BTK was recently linked to the innate immune system, in particular, the Toll-like receptor (TLR) pathway; howev...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2014-06, Vol.133 (6), p.1644-1650.e4
Hauptverfasser:	Lougaris, Vassilios, MD, Baronio, Manuela, PhD, Vitali, Massimiliano, PhD, Tampella, Giacomo, PhD, Cattalini, Marco, MD, Tassone, Laura, PhD, Soresina, Annarosa, MD, Badolato, Raffaele, MD, PhD, Plebani, Alessandro, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Agammaglobulinemia - genetics Agammaglobulinemia - immunology Agammaglobulinemia - metabolism Allergy and Immunology Biological and medical sciences BTK Cytokines - biosynthesis dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Genetic Diseases, X-Linked - genetics Genetic Diseases, X-Linked - immunology Genetic Diseases, X-Linked - metabolism Humans Immunopathology Immunophenotyping Lipopolysaccharides - immunology Lipopolysaccharides - pharmacology Medical sciences Oligodeoxyribonucleotides - pharmacology Phenotype Protein-Tyrosine Kinases - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis STAT1 STAT1 Transcription Factor - metabolism STAT3 STAT3 Transcription Factor - metabolism TLR9 Toll-Like Receptor 9 - metabolism
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