Interleukin-22 and interleukin-22-producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis

Objective The intestinal inflammation observed in patients with ankylosing spondylitis (AS) is characterized by an overexpression of interleukin‐23 (IL‐23). IL‐23 is known to regulate IL‐22 production through lamina propria NKp44+ natural killer (NK) cells, which are thought to be involved in protec...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2012-06, Vol.64 (6), p.1869-1878
Hauptverfasser:	Ciccia, Francesco, Accardo-Palumbo, Antonina, Alessandro, Riccardo, Rizzo, Aroldo, Principe, Simona, Peralta, Sergio, Raiata, Francesca, Giardina, AnnaRita, De Leo, Giacomo, Triolo, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Bowel disease Diseases of the osteoarticular system Diseases of the spine Female Gene expression Humans Ileum - immunology Ileum - metabolism Immune system Inflammation - immunology Inflammation - metabolism Inflammatory joint diseases Interleukin-22 Interleukin-23 - genetics Interleukin-23 - metabolism Interleukins - genetics Interleukins - metabolism Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Male Medical sciences Middle Aged Mucin-1 - genetics Mucin-1 - metabolism Natural Cytotoxicity Triggering Receptor 2 - analysis Spondylitis, Ankylosing - immunology Spondylitis, Ankylosing - metabolism STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism
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