Coumestrol suppresses hypoxia inducible factor 1α by inhibiting ROS mediated sphingosine kinase 1 in hypoxic PC-3 prostate cancer cells

Among many signals to regulate hypoxia inducible factor 1α (HIF-1α), sphingosine kinase 1 (SPHK1) is also involved in various biological activities such as cell growth, survival, invasion, angiogenesis, and carcinogenesis. Thus, in the present study, molecular mechanisms of coumestrol were investiga...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-06, Vol.24 (11), p.2560-2564
Hauptverfasser:	Cho, Sung-Yun, Cho, Sunmi, Park, Eunkyung, Kim, Bonglee, Sohn, Eun Jung, Oh, Bumsuk, Lee, Eun-Ok, Lee, Hyo-Jeong, Kim, Sung-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Coumestrol Coumestrol - chemistry Coumestrol - pharmacology Dose-Response Relationship, Drug Humans Hypoxia inducible factor 1α Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors Molecular Structure Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Phosphotransferases (Alcohol Group Acceptor) - metabolism Reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!