Sustained sympathetic nervous system support of arterial blood pressure during repeated brief umbilical cord occlusions in near-term fetal sheep
Sympathetic nervous system (SNS)-mediated peripheral vasoconstriction plays a key role in initial maintenance of blood pressure during rapid-onset asphyxia in the mammalian fetus, but it is attenuated after the first few minutes. It is unclear whether the SNS response is sustained during the brief,...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2014-06, Vol.306 (11), p.R787-R795 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
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| creator | Galinsky, Robert Jensen, Ellen C Bennet, Laura Mitchell, Clinton J Gunn, Eleanor R Wassink, Guido Fraser, Mhoyra Westgate, Jennifer A Gunn, Alistair J |
| description | Sympathetic nervous system (SNS)-mediated peripheral vasoconstriction plays a key role in initial maintenance of blood pressure during rapid-onset asphyxia in the mammalian fetus, but it is attenuated after the first few minutes. It is unclear whether the SNS response is sustained during the brief, but frequently repeated, episodes of asphyxia characteristic of labor. In the present study, 14 fetal sheep at 0.85 of gestation received either chemical sympathectomy with 6-hydroxydopamine (6-OHDA; n = 7) or sham injection (control; n = 7), followed 4-5 days later by repeated 2-min episodes of complete umbilical cord occlusion every 5 min for up to 4 h or until mean arterial blood pressure (MAP) fell to |
| doi_str_mv | 10.1152/ajpregu.00001.2014 |
| format | Article |
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It is unclear whether the SNS response is sustained during the brief, but frequently repeated, episodes of asphyxia characteristic of labor. In the present study, 14 fetal sheep at 0.85 of gestation received either chemical sympathectomy with 6-hydroxydopamine (6-OHDA; n = 7) or sham injection (control; n = 7), followed 4-5 days later by repeated 2-min episodes of complete umbilical cord occlusion every 5 min for up to 4 h or until mean arterial blood pressure (MAP) fell to <20 mmHg for two successive occlusions. In controls, umbilical cord occlusions were associated with a rapid initial fall in fetal heart rate (FHR) and femoral blood flow (FBF), with initial hypertension, followed by progressive development of hypotension during ongoing occlusions. Sympathectomy was associated with attenuation of the initial rise in MAP during umbilical cord occlusion, and after the onset of hypotension, a markedly more rapid fall of MAP to the nadir, with a correspondingly slower fall in FBF (P < 0.05). In contrast, MAP and FHR between successive occlusions were higher after sympathectomy (P < 0.05). There was no significant difference in the number of occlusions before terminal hypotension (6-OHDA; 16.1 ± 2.2 vs. control; 18.7 ± 2.3). These data show that SNS activity provides ongoing support for fetal MAP during prolonged exposure to brief repeated asphyxia.</description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.00001.2014</identifier><identifier>PMID: 24647590</identifier><identifier>CODEN: AJPRDO</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Animals ; Asphyxia - physiopathology ; Blood pressure ; Blood Pressure - physiology ; Female ; Fetus - physiology ; Heart Rate - physiology ; Models, Animal ; Nervous system ; Oxidopamine - pharmacology ; Pregnancy ; Regional Blood Flow - physiology ; Sheep ; Suffocation ; Sympathectomy, Chemical - methods ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiology ; Sympatholytics - pharmacology ; Umbilical Arteries - physiopathology ; Umbilical Cord - blood supply ; Vasoconstriction - physiology</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2014-06, Vol.306 (11), p.R787-R795</ispartof><rights>Copyright © 2014 the American Physiological Society.</rights><rights>Copyright American Physiological Society Jun 1, 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-161f36f0f9ea7af2d797840966eedd50f6266f95c4ca42b178fbbb0aac50f8563</citedby><cites>FETCH-LOGICAL-c397t-161f36f0f9ea7af2d797840966eedd50f6266f95c4ca42b178fbbb0aac50f8563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24647590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galinsky, Robert</creatorcontrib><creatorcontrib>Jensen, Ellen C</creatorcontrib><creatorcontrib>Bennet, Laura</creatorcontrib><creatorcontrib>Mitchell, Clinton J</creatorcontrib><creatorcontrib>Gunn, Eleanor R</creatorcontrib><creatorcontrib>Wassink, Guido</creatorcontrib><creatorcontrib>Fraser, Mhoyra</creatorcontrib><creatorcontrib>Westgate, Jennifer A</creatorcontrib><creatorcontrib>Gunn, Alistair J</creatorcontrib><title>Sustained sympathetic nervous system support of arterial blood pressure during repeated brief umbilical cord occlusions in near-term fetal sheep</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description>Sympathetic nervous system (SNS)-mediated peripheral vasoconstriction plays a key role in initial maintenance of blood pressure during rapid-onset asphyxia in the mammalian fetus, but it is attenuated after the first few minutes. It is unclear whether the SNS response is sustained during the brief, but frequently repeated, episodes of asphyxia characteristic of labor. In the present study, 14 fetal sheep at 0.85 of gestation received either chemical sympathectomy with 6-hydroxydopamine (6-OHDA; n = 7) or sham injection (control; n = 7), followed 4-5 days later by repeated 2-min episodes of complete umbilical cord occlusion every 5 min for up to 4 h or until mean arterial blood pressure (MAP) fell to <20 mmHg for two successive occlusions. In controls, umbilical cord occlusions were associated with a rapid initial fall in fetal heart rate (FHR) and femoral blood flow (FBF), with initial hypertension, followed by progressive development of hypotension during ongoing occlusions. Sympathectomy was associated with attenuation of the initial rise in MAP during umbilical cord occlusion, and after the onset of hypotension, a markedly more rapid fall of MAP to the nadir, with a correspondingly slower fall in FBF (P < 0.05). In contrast, MAP and FHR between successive occlusions were higher after sympathectomy (P < 0.05). There was no significant difference in the number of occlusions before terminal hypotension (6-OHDA; 16.1 ± 2.2 vs. control; 18.7 ± 2.3). These data show that SNS activity provides ongoing support for fetal MAP during prolonged exposure to brief repeated asphyxia.</description><subject>Animals</subject><subject>Asphyxia - physiopathology</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Female</subject><subject>Fetus - physiology</subject><subject>Heart Rate - physiology</subject><subject>Models, Animal</subject><subject>Nervous system</subject><subject>Oxidopamine - pharmacology</subject><subject>Pregnancy</subject><subject>Regional Blood Flow - physiology</subject><subject>Sheep</subject><subject>Suffocation</subject><subject>Sympathectomy, Chemical - methods</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Sympatholytics - pharmacology</subject><subject>Umbilical Arteries - physiopathology</subject><subject>Umbilical Cord - blood supply</subject><subject>Vasoconstriction - physiology</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9u1DAQhy0EokvhBTggS1y4ZLFjx1kfUcWfSpU4AOfIccatV0kcZmykvgWPjJcuHOqLJc83vxnrY-y1FHspu_a9O24It2Uv6pH7Vkj9hO1qoW2ktuIp2wllVGOktBfsBdGxYlpp9ZxdtNrovrNix35_K5RdXGHidL9sLt9Bjp6vgL9SofpGGRZOZdsSZp4Cd5gBo5v5OKc08boBUUHgU8G43nKEDVyuaSNGCLwsY5yjr7hPOPHk_VwoppV4XOsQh01NW3iAXBG6A9hesmfBzQSvzvcl-_Hp4_erL83N18_XVx9uGq9snxtpZFAmiGDB9S60U2_7gxbWGIBp6kQwrTHBdl57p9tR9ocwjqNwztfaoTPqkr17yN0w_SxAeVgieZhnt0L9-SA7pXtrpDihbx-hx1RwrdtVSovu0PVaVqp9oDwmIoQwbBgXh_eDFMPJ13D2Nfz1NZx81aY35-gyLjD9b_knSP0BwSWWWA</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Galinsky, Robert</creator><creator>Jensen, Ellen C</creator><creator>Bennet, Laura</creator><creator>Mitchell, Clinton J</creator><creator>Gunn, Eleanor R</creator><creator>Wassink, Guido</creator><creator>Fraser, Mhoyra</creator><creator>Westgate, Jennifer A</creator><creator>Gunn, Alistair J</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Sustained sympathetic nervous system support of arterial blood pressure during repeated brief umbilical cord occlusions in near-term fetal sheep</title><author>Galinsky, Robert ; Jensen, Ellen C ; Bennet, Laura ; Mitchell, Clinton J ; Gunn, Eleanor R ; Wassink, Guido ; Fraser, Mhoyra ; Westgate, Jennifer A ; Gunn, Alistair J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-161f36f0f9ea7af2d797840966eedd50f6266f95c4ca42b178fbbb0aac50f8563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Asphyxia - physiopathology</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Female</topic><topic>Fetus - physiology</topic><topic>Heart Rate - physiology</topic><topic>Models, Animal</topic><topic>Nervous system</topic><topic>Oxidopamine - pharmacology</topic><topic>Pregnancy</topic><topic>Regional Blood Flow - physiology</topic><topic>Sheep</topic><topic>Suffocation</topic><topic>Sympathectomy, Chemical - methods</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Sympatholytics - pharmacology</topic><topic>Umbilical Arteries - physiopathology</topic><topic>Umbilical Cord - blood supply</topic><topic>Vasoconstriction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galinsky, Robert</creatorcontrib><creatorcontrib>Jensen, Ellen C</creatorcontrib><creatorcontrib>Bennet, Laura</creatorcontrib><creatorcontrib>Mitchell, Clinton J</creatorcontrib><creatorcontrib>Gunn, Eleanor R</creatorcontrib><creatorcontrib>Wassink, Guido</creatorcontrib><creatorcontrib>Fraser, Mhoyra</creatorcontrib><creatorcontrib>Westgate, Jennifer A</creatorcontrib><creatorcontrib>Gunn, Alistair J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galinsky, Robert</au><au>Jensen, Ellen C</au><au>Bennet, Laura</au><au>Mitchell, Clinton J</au><au>Gunn, Eleanor R</au><au>Wassink, Guido</au><au>Fraser, Mhoyra</au><au>Westgate, Jennifer A</au><au>Gunn, Alistair J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sustained sympathetic nervous system support of arterial blood pressure during repeated brief umbilical cord occlusions in near-term fetal sheep</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>306</volume><issue>11</issue><spage>R787</spage><epage>R795</epage><pages>R787-R795</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><coden>AJPRDO</coden><abstract>Sympathetic nervous system (SNS)-mediated peripheral vasoconstriction plays a key role in initial maintenance of blood pressure during rapid-onset asphyxia in the mammalian fetus, but it is attenuated after the first few minutes. It is unclear whether the SNS response is sustained during the brief, but frequently repeated, episodes of asphyxia characteristic of labor. In the present study, 14 fetal sheep at 0.85 of gestation received either chemical sympathectomy with 6-hydroxydopamine (6-OHDA; n = 7) or sham injection (control; n = 7), followed 4-5 days later by repeated 2-min episodes of complete umbilical cord occlusion every 5 min for up to 4 h or until mean arterial blood pressure (MAP) fell to <20 mmHg for two successive occlusions. In controls, umbilical cord occlusions were associated with a rapid initial fall in fetal heart rate (FHR) and femoral blood flow (FBF), with initial hypertension, followed by progressive development of hypotension during ongoing occlusions. Sympathectomy was associated with attenuation of the initial rise in MAP during umbilical cord occlusion, and after the onset of hypotension, a markedly more rapid fall of MAP to the nadir, with a correspondingly slower fall in FBF (P < 0.05). In contrast, MAP and FHR between successive occlusions were higher after sympathectomy (P < 0.05). There was no significant difference in the number of occlusions before terminal hypotension (6-OHDA; 16.1 ± 2.2 vs. control; 18.7 ± 2.3). These data show that SNS activity provides ongoing support for fetal MAP during prolonged exposure to brief repeated asphyxia.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>24647590</pmid><doi>10.1152/ajpregu.00001.2014</doi></addata></record> |
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| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 2014-06, Vol.306 (11), p.R787-R795 |
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| source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Asphyxia - physiopathology Blood pressure Blood Pressure - physiology Female Fetus - physiology Heart Rate - physiology Models, Animal Nervous system Oxidopamine - pharmacology Pregnancy Regional Blood Flow - physiology Sheep Suffocation Sympathectomy, Chemical - methods Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology Sympatholytics - pharmacology Umbilical Arteries - physiopathology Umbilical Cord - blood supply Vasoconstriction - physiology |
| title | Sustained sympathetic nervous system support of arterial blood pressure during repeated brief umbilical cord occlusions in near-term fetal sheep |
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