Inhibitory effect of selected medicinal plants on the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells
The inhibitory activities of the methanol extracts from 20 selected medicinal plants on the release of pro-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs) were evaluated. The major compound from the most active plant extract was also investigated. The inhibitory effect of...
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| Veröffentlicht in: | Journal of natural medicines 2014-07, Vol.68 (3), p.647-653 |
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| creator | Salim, Emil Kumolosasi, Endang Jantan, Ibrahim |
| description | The inhibitory activities of the methanol extracts from 20 selected medicinal plants on the release of pro-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs) were evaluated. The major compound from the most active plant extract was also investigated. The inhibitory effect of the methanol extracts on the release of pro-inflammatory cytokines was tested by incubating PBMCs with the sample and then stimulating by lipopolysaccharide at 0.1 μg/ml. The level of cytokines was determined using enzyme-linked immunosorbent assay. Among the extracts tested,
Andrographis paniculata
extract demonstrated the strongest inhibition of interleukin (IL)-1β, IL-1α, and IL-6 release, with IC
50
values of 1.54, 1.06, and 0.74 μg/ml, respectively. The IC
50
value of
A. paniculata
extract was significantly higher than that of andrographolide on IL-1α, IL-1β, and IL-6 (
p
|
| doi_str_mv | 10.1007/s11418-014-0841-0 |
| format | Article |
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Andrographis paniculata
extract demonstrated the strongest inhibition of interleukin (IL)-1β, IL-1α, and IL-6 release, with IC
50
values of 1.54, 1.06, and 0.74 μg/ml, respectively. The IC
50
value of
A. paniculata
extract was significantly higher than that of andrographolide on IL-1α, IL-1β, and IL-6 (
p
< 0.001) release. The IC
50
values of andrographolide for IL-1α, IL-1β, and IL-6 were significantly higher (
p
< 0.001) than that of dexamethasone.
Cymbopogon citratus
and
Zingiber officinale
strongly inhibited the release of IL-1β, with IC
50
values of 3.22 and 3.17 μg/ml, respectively. To our knowledge, this is the first report that
A. paniculata
extract and its major compound andrographolide strongly inhibited the release of IL-1α, whereas previous studies only showed their inhibitory effect on the release of another IL-1 family member, IL-1β. The results show that these extracts and this compound have potential effects as anti-inflammatory agents by inhibiting the release of pro-inflammatory cytokines.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-014-0841-0</identifier><identifier>PMID: 24799081</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Andrographis - chemistry ; Anti-Inflammatory Agents - pharmacology ; Biomedical and Life Sciences ; Biomedicine ; Complementary & Alternative Medicine ; Cytokines - metabolism ; Diterpenes - chemistry ; Diterpenes - pharmacology ; Humans ; Inflammation Mediators - metabolism ; Interleukins - metabolism ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - immunology ; Lipopolysaccharides - pharmacology ; Medicinal Chemistry ; Natural Resource Letter ; Pharmacology/Toxicology ; Pharmacy ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Sciences ; Plants, Medicinal - chemistry</subject><ispartof>Journal of natural medicines, 2014-07, Vol.68 (3), p.647-653</ispartof><rights>The Japanese Society of Pharmacognosy and Springer Japan 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-bc35c2705ad0a55a2bc7bf363df1300f88e6d455725ce6b6d92455a7087b04e83</citedby><cites>FETCH-LOGICAL-c428t-bc35c2705ad0a55a2bc7bf363df1300f88e6d455725ce6b6d92455a7087b04e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-014-0841-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-014-0841-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24799081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salim, Emil</creatorcontrib><creatorcontrib>Kumolosasi, Endang</creatorcontrib><creatorcontrib>Jantan, Ibrahim</creatorcontrib><title>Inhibitory effect of selected medicinal plants on the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>The inhibitory activities of the methanol extracts from 20 selected medicinal plants on the release of pro-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs) were evaluated. The major compound from the most active plant extract was also investigated. The inhibitory effect of the methanol extracts on the release of pro-inflammatory cytokines was tested by incubating PBMCs with the sample and then stimulating by lipopolysaccharide at 0.1 μg/ml. The level of cytokines was determined using enzyme-linked immunosorbent assay. Among the extracts tested,
Andrographis paniculata
extract demonstrated the strongest inhibition of interleukin (IL)-1β, IL-1α, and IL-6 release, with IC
50
values of 1.54, 1.06, and 0.74 μg/ml, respectively. The IC
50
value of
A. paniculata
extract was significantly higher than that of andrographolide on IL-1α, IL-1β, and IL-6 (
p
< 0.001) release. The IC
50
values of andrographolide for IL-1α, IL-1β, and IL-6 were significantly higher (
p
< 0.001) than that of dexamethasone.
Cymbopogon citratus
and
Zingiber officinale
strongly inhibited the release of IL-1β, with IC
50
values of 3.22 and 3.17 μg/ml, respectively. To our knowledge, this is the first report that
A. paniculata
extract and its major compound andrographolide strongly inhibited the release of IL-1α, whereas previous studies only showed their inhibitory effect on the release of another IL-1 family member, IL-1β. The results show that these extracts and this compound have potential effects as anti-inflammatory agents by inhibiting the release of pro-inflammatory cytokines.</description><subject>Andrographis - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Complementary & Alternative Medicine</subject><subject>Cytokines - metabolism</subject><subject>Diterpenes - chemistry</subject><subject>Diterpenes - pharmacology</subject><subject>Humans</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interleukins - metabolism</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Medicinal Chemistry</subject><subject>Natural Resource Letter</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Sciences</subject><subject>Plants, Medicinal - chemistry</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu1TAUtBCIPugHsEFesnHxM_FdoopCpUps6NpynOPGxbGDnSzuB_GfdbiFJSuP5TkzxzMIvWf0mlHaf6qMSaYJZZJQLRmhr9A5010D_CBeNywkJUJKcYYuan2iVHIh2Ft0xmV_OFDNztHvuzSFIay5HDF4D27F2eMKsSEY8QxjcCHZiJdo01pxTnidAJdGsBV27lIyCclHO8_2j4w7rvlnSFBxSDiGJS85Hqt1brIljEDqGuYt2l1-2mab8AIlLBOU5jLEnJtrTjltrlkU7CDG-g698TZWuHo5L9HD7ZcfN9_I_fevdzef74mTXK9kcEI53lNlR2qVsnxw_eBFJ0bPBKVea-hGqVTPlYNu6MYDbzfbU90PVIIWl-jjSbd96tcGdTVzqPsGNkHeqmFKtOS44n2jshPVlVxrAW-WEmZbjoZRs7djTu2Y1o7Z2zG0zXx4kd-Gluy_ib91NAI_EWp7So9QzFPeSou__kf1GR6fnxA</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Salim, Emil</creator><creator>Kumolosasi, Endang</creator><creator>Jantan, Ibrahim</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Inhibitory effect of selected medicinal plants on the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells</title><author>Salim, Emil ; Kumolosasi, Endang ; Jantan, Ibrahim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-bc35c2705ad0a55a2bc7bf363df1300f88e6d455725ce6b6d92455a7087b04e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Andrographis - chemistry</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Complementary & Alternative Medicine</topic><topic>Cytokines - metabolism</topic><topic>Diterpenes - chemistry</topic><topic>Diterpenes - pharmacology</topic><topic>Humans</topic><topic>Inflammation Mediators - metabolism</topic><topic>Interleukins - metabolism</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Medicinal Chemistry</topic><topic>Natural Resource Letter</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Sciences</topic><topic>Plants, Medicinal - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salim, Emil</creatorcontrib><creatorcontrib>Kumolosasi, Endang</creatorcontrib><creatorcontrib>Jantan, Ibrahim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salim, Emil</au><au>Kumolosasi, Endang</au><au>Jantan, Ibrahim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effect of selected medicinal plants on the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>68</volume><issue>3</issue><spage>647</spage><epage>653</epage><pages>647-653</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>The inhibitory activities of the methanol extracts from 20 selected medicinal plants on the release of pro-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs) were evaluated. The major compound from the most active plant extract was also investigated. The inhibitory effect of the methanol extracts on the release of pro-inflammatory cytokines was tested by incubating PBMCs with the sample and then stimulating by lipopolysaccharide at 0.1 μg/ml. The level of cytokines was determined using enzyme-linked immunosorbent assay. Among the extracts tested,
Andrographis paniculata
extract demonstrated the strongest inhibition of interleukin (IL)-1β, IL-1α, and IL-6 release, with IC
50
values of 1.54, 1.06, and 0.74 μg/ml, respectively. The IC
50
value of
A. paniculata
extract was significantly higher than that of andrographolide on IL-1α, IL-1β, and IL-6 (
p
< 0.001) release. The IC
50
values of andrographolide for IL-1α, IL-1β, and IL-6 were significantly higher (
p
< 0.001) than that of dexamethasone.
Cymbopogon citratus
and
Zingiber officinale
strongly inhibited the release of IL-1β, with IC
50
values of 3.22 and 3.17 μg/ml, respectively. To our knowledge, this is the first report that
A. paniculata
extract and its major compound andrographolide strongly inhibited the release of IL-1α, whereas previous studies only showed their inhibitory effect on the release of another IL-1 family member, IL-1β. The results show that these extracts and this compound have potential effects as anti-inflammatory agents by inhibiting the release of pro-inflammatory cytokines.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24799081</pmid><doi>10.1007/s11418-014-0841-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Andrographis - chemistry Anti-Inflammatory Agents - pharmacology Biomedical and Life Sciences Biomedicine Complementary & Alternative Medicine Cytokines - metabolism Diterpenes - chemistry Diterpenes - pharmacology Humans Inflammation Mediators - metabolism Interleukins - metabolism Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Lipopolysaccharides - pharmacology Medicinal Chemistry Natural Resource Letter Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Extracts - pharmacology Plant Sciences Plants, Medicinal - chemistry |
| title | Inhibitory effect of selected medicinal plants on the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells |
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