Depression and seizures as the main neuropsychiatric manifestation of mixed connective tissue disorder

A 38 years female presented with arthralgia, dyspnoea, progressive proximal muscle weakness, seizures, weight loss, dysphagia, alopecia, and dryness of the eyes and mouth with tightening of the skin. Psychiatric evaluation revealed major depression. She had oral ulcers, tightening of the skin of the...

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Veröffentlicht in:Journal of the College of Physicians and Surgeons--Pakistan 2014-05, Vol.24 Suppl 2, p.S141-S143
Hauptverfasser: Kiani, Ismaa Ghazanfar, Qureshi, Safina Hameed, Shah, Faridullah
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Qureshi, Safina Hameed
Shah, Faridullah
description A 38 years female presented with arthralgia, dyspnoea, progressive proximal muscle weakness, seizures, weight loss, dysphagia, alopecia, and dryness of the eyes and mouth with tightening of the skin. Psychiatric evaluation revealed major depression. She had oral ulcers, tightening of the skin of the hands with restricted mouth opening, and proximal muscle weakness. Mixed connective tissue disorder (MCTD) with predominant polymyositis and neuropsychiatric manifestations was diagnosed as the patient had anti-RNP positive with significantly raised muscle enzymes. This case is unique because major depression in MCTD is rarely documented, severe polymyositis is a rarity and ANA was negative but characteristic anti-RNP antibody was positive.
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subjects Adult
Antibodies, Antinuclear - analysis
Anticonvulsants - therapeutic use
Antidepressive Agents, Second-Generation - therapeutic use
Azathioprine - administration & dosage
Citalopram - therapeutic use
Depression - diagnosis
Depression - etiology
Depression - psychology
Electromyography
Female
Humans
Immunosuppressive Agents - administration & dosage
Methylprednisolone - administration & dosage
Mixed Connective Tissue Disease - drug therapy
Mixed Connective Tissue Disease - pathology
Mixed Connective Tissue Disease - psychology
Polymyositis - drug therapy
Polymyositis - pathology
Seizures - etiology
Skin - pathology
Treatment Outcome
Valproic Acid - therapeutic use
title Depression and seizures as the main neuropsychiatric manifestation of mixed connective tissue disorder
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