Depression and seizures as the main neuropsychiatric manifestation of mixed connective tissue disorder
A 38 years female presented with arthralgia, dyspnoea, progressive proximal muscle weakness, seizures, weight loss, dysphagia, alopecia, and dryness of the eyes and mouth with tightening of the skin. Psychiatric evaluation revealed major depression. She had oral ulcers, tightening of the skin of the...
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Veröffentlicht in: | Journal of the College of Physicians and Surgeons--Pakistan 2014-05, Vol.24 Suppl 2, p.S141-S143 |
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description | A 38 years female presented with arthralgia, dyspnoea, progressive proximal muscle weakness, seizures, weight loss, dysphagia, alopecia, and dryness of the eyes and mouth with tightening of the skin. Psychiatric evaluation revealed major depression. She had oral ulcers, tightening of the skin of the hands with restricted mouth opening, and proximal muscle weakness. Mixed connective tissue disorder (MCTD) with predominant polymyositis and neuropsychiatric manifestations was diagnosed as the patient had anti-RNP positive with significantly raised muscle enzymes. This case is unique because major depression in MCTD is rarely documented, severe polymyositis is a rarity and ANA was negative but characteristic anti-RNP antibody was positive. |
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Psychiatric evaluation revealed major depression. She had oral ulcers, tightening of the skin of the hands with restricted mouth opening, and proximal muscle weakness. Mixed connective tissue disorder (MCTD) with predominant polymyositis and neuropsychiatric manifestations was diagnosed as the patient had anti-RNP positive with significantly raised muscle enzymes. This case is unique because major depression in MCTD is rarely documented, severe polymyositis is a rarity and ANA was negative but characteristic anti-RNP antibody was positive.</description><identifier>EISSN: 1681-7168</identifier><identifier>PMID: 24906270</identifier><language>eng</language><publisher>Pakistan</publisher><subject>Adult ; Antibodies, Antinuclear - analysis ; Anticonvulsants - therapeutic use ; Antidepressive Agents, Second-Generation - therapeutic use ; Azathioprine - administration & dosage ; Citalopram - therapeutic use ; Depression - diagnosis ; Depression - etiology ; Depression - psychology ; Electromyography ; Female ; Humans ; Immunosuppressive Agents - administration & dosage ; Methylprednisolone - administration & dosage ; Mixed Connective Tissue Disease - drug therapy ; Mixed Connective Tissue Disease - pathology ; Mixed Connective Tissue Disease - psychology ; Polymyositis - drug therapy ; Polymyositis - pathology ; Seizures - etiology ; Skin - pathology ; Treatment Outcome ; Valproic Acid - therapeutic use</subject><ispartof>Journal of the College of Physicians and Surgeons--Pakistan, 2014-05, Vol.24 Suppl 2, p.S141-S143</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24906270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiani, Ismaa Ghazanfar</creatorcontrib><creatorcontrib>Qureshi, Safina Hameed</creatorcontrib><creatorcontrib>Shah, Faridullah</creatorcontrib><title>Depression and seizures as the main neuropsychiatric manifestation of mixed connective tissue disorder</title><title>Journal of the College of Physicians and Surgeons--Pakistan</title><addtitle>J Coll Physicians Surg Pak</addtitle><description>A 38 years female presented with arthralgia, dyspnoea, progressive proximal muscle weakness, seizures, weight loss, dysphagia, alopecia, and dryness of the eyes and mouth with tightening of the skin. Psychiatric evaluation revealed major depression. She had oral ulcers, tightening of the skin of the hands with restricted mouth opening, and proximal muscle weakness. Mixed connective tissue disorder (MCTD) with predominant polymyositis and neuropsychiatric manifestations was diagnosed as the patient had anti-RNP positive with significantly raised muscle enzymes. 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subjects | Adult Antibodies, Antinuclear - analysis Anticonvulsants - therapeutic use Antidepressive Agents, Second-Generation - therapeutic use Azathioprine - administration & dosage Citalopram - therapeutic use Depression - diagnosis Depression - etiology Depression - psychology Electromyography Female Humans Immunosuppressive Agents - administration & dosage Methylprednisolone - administration & dosage Mixed Connective Tissue Disease - drug therapy Mixed Connective Tissue Disease - pathology Mixed Connective Tissue Disease - psychology Polymyositis - drug therapy Polymyositis - pathology Seizures - etiology Skin - pathology Treatment Outcome Valproic Acid - therapeutic use |
title | Depression and seizures as the main neuropsychiatric manifestation of mixed connective tissue disorder |
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