Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

MicroRNAs (miRNAs) control gene expression by regulating mRNA translation and stability. The CCR4-NOT complex is a key effector of miRNA function acting downstream of GW182/TNRC6 proteins. We show that miRNA-mediated repression requires the central region of CNOT1, the scaffold protein of CCR4-NOT....

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Veröffentlicht in:	Molecular cell 2014-06, Vol.54 (5), p.751-765
Hauptverfasser:	Mathys, Hansruedi, Basquin, Jérôme, Ozgur, Sevim, Czarnocki-Cieciura, Mariusz, Bonneau, Fabien, Aartse, Aafke, Dziembowski, Andrzej, Nowotny, Marcin, Conti, Elena, Filipowicz, Witold
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Binding Sites Crystallography, X-Ray DEAD-box RNA Helicases - chemistry DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism HEK293 Cells Humans MicroRNAs - genetics Models, Molecular Multiprotein Complexes - chemistry Mutagenesis, Site-Directed Protein Binding Protein Interaction Domains and Motifs Protein Structure, Quaternary Protein Structure, Secondary Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RNA Interference Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
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