Cytotoxic benzophenone and triterpene from Garcinia hombroniana

[Display omitted] •Fifteen compounds were isolated from Garcinia hombroniana.•Compounds 1 and 9 induced DBTRG cells death.•Compounds 1–8 exhibited strong antioxidant activities. Garcinia hombroniana (seashore mangosteen) in Malaysia is used to treat itching and as a protective medicine after child b...

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Veröffentlicht in:	Bioorganic chemistry 2014-06, Vol.54, p.60-67
Hauptverfasser:	Jamila, Nargis, Khairuddean, Melati, Yaacob, Nik Soriani, Kamal, Nik Nur Syazni Nik Mohamed, Osman, Hasnah, Khan, Sadiq Noor, Khan, Naeem
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Antioxidant activities Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Bark Benzophenones Benzophenones - chemistry Benzophenones - isolation & purification Benzophenones - pharmacology Benzothiazoles - antagonists & inhibitors Biphenyl Compounds - antagonists & inhibitors Cell Death - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cytotoxicity Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Free Radicals - antagonists & inhibitors Garcinia - chemistry Garcinia hombroniana Humans MCF-7 Cells Molecular Structure Picrates - antagonists & inhibitors Structure-Activity Relationship Sulfonic Acids - antagonists & inhibitors Triterpenes Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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