Desogestrel-only contraceptive pill versus sequential contraceptive vaginal ring in the treatment of rectovaginal endometriosis infiltrating the rectum: a prospective open-label comparative study
Objective To compare the efficacy of two hormonal therapies in treating symptoms caused by bowel endometriosis. Design Patient preference study. Setting University hospital. Population A total of 143 women with rectovaginal endometriosis infiltrating the rectum. Methods This study was performed betw...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 2014-03, Vol.93 (3), p.239-247 |
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| container_title | Acta obstetricia et gynecologica Scandinavica |
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| creator | Leone Roberti Maggiore, Umberto Remorgida, Valentino Scala, Carolina Tafi, Emanuela Venturini, Pier L. Ferrero, Simone |
| description | Objective
To compare the efficacy of two hormonal therapies in treating symptoms caused by bowel endometriosis.
Design
Patient preference study.
Setting
University hospital.
Population
A total of 143 women with rectovaginal endometriosis infiltrating the rectum.
Methods
This study was performed between January 2008 and June 2011. Patients were treated with a desogestrel‐only contraceptive pill or with the sequential combined contraceptive vaginal ring for 12 months.
Main outcome measures
The primary endpoint of the study was the rate of satisfied patients at 12‐month follow up. The changes in symptoms and in the volume of the nodules were secondary endpoints.
Results
At 12‐month follow up, the rate of satisfied patients was higher in the group treated with the desogestrel‐only contraceptive pill than in the group treated with the sequential combined contraceptive vaginal ring (p = 0.004). When only changes in gastrointestinal symptoms were considered, 50% of patients treated with the desogestrel‐only contraceptive pill and 31.3% of those treated with the sequential combined contraceptive vaginal ring were satisfied (p = 0.037). The reduction in the volume of the nodules, the percentages of patients who discontinued the therapy after the completion of the study and of those who decided to undergo surgery were similar between the two groups.
Conclusions
Both hormonal therapies are efficacious in treating symptoms caused by rectovaginal endometriosis infiltrating the rectum. Patient satisfaction is higher with the desogestrel‐only pill than with a vaginal ring. |
| doi_str_mv | 10.1111/aogs.12326 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1534472329</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1534472329</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4616-426108c32d0b82e471dd8cbf636a10c52ed765bf08542ce5b2a96736d030261c3</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxiMEokvhwgMgS1wQUortOM6GWymwIEor_qncLMeZLG6dONjOwj4fL8aE7fbQA75YM_p933j8ZdljRo8Ynhfar-MR4wWXd7IFk5TmVDB-N1tQSlkuC1EfZA9ivMSKV2J5Pzvgoqh4yapF9uc1RL-GmAK43A9uS4wfUtAGxmQ3QEbrHNlAiFMkEX5OMCSr3S1oo9d2wG6ww5rYgaQfQNBQpx5x4jsSwCS_p2BofQ8pWB9tRLyzDr3SrJ2FMzv1L4kmY_BxxGoe4UcYcqcbmGf3o54F2I5parcPs3uddhEeXd-H2be3b76evMtPz1fvT45PcyMkk7ngktGlKXhLmyUHUbG2XZqmk4XUjJqSQ1vJsunoshTcQNlwXcuqkC0tKEpNcZg92_niw_AnYlK9jQac0wP4KSpWFkJUmEON6NNb6KWfAm6PlKhrQWktBFLPd5TBTWOATo3B9jpsFaNqjlbN0ap_0SL85Npyanpob9B9lgiwHfDLOtj-x0odn6--7E3zncbGBL9vNDpcKVy9KtXF2UqdffwkPr_6fqE-FH8B3zTDWQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1499400944</pqid></control><display><type>article</type><title>Desogestrel-only contraceptive pill versus sequential contraceptive vaginal ring in the treatment of rectovaginal endometriosis infiltrating the rectum: a prospective open-label comparative study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Leone Roberti Maggiore, Umberto ; Remorgida, Valentino ; Scala, Carolina ; Tafi, Emanuela ; Venturini, Pier L. ; Ferrero, Simone</creator><creatorcontrib>Leone Roberti Maggiore, Umberto ; Remorgida, Valentino ; Scala, Carolina ; Tafi, Emanuela ; Venturini, Pier L. ; Ferrero, Simone</creatorcontrib><description>Objective
To compare the efficacy of two hormonal therapies in treating symptoms caused by bowel endometriosis.
Design
Patient preference study.
Setting
University hospital.
Population
A total of 143 women with rectovaginal endometriosis infiltrating the rectum.
Methods
This study was performed between January 2008 and June 2011. Patients were treated with a desogestrel‐only contraceptive pill or with the sequential combined contraceptive vaginal ring for 12 months.
Main outcome measures
The primary endpoint of the study was the rate of satisfied patients at 12‐month follow up. The changes in symptoms and in the volume of the nodules were secondary endpoints.
Results
At 12‐month follow up, the rate of satisfied patients was higher in the group treated with the desogestrel‐only contraceptive pill than in the group treated with the sequential combined contraceptive vaginal ring (p = 0.004). When only changes in gastrointestinal symptoms were considered, 50% of patients treated with the desogestrel‐only contraceptive pill and 31.3% of those treated with the sequential combined contraceptive vaginal ring were satisfied (p = 0.037). The reduction in the volume of the nodules, the percentages of patients who discontinued the therapy after the completion of the study and of those who decided to undergo surgery were similar between the two groups.
Conclusions
Both hormonal therapies are efficacious in treating symptoms caused by rectovaginal endometriosis infiltrating the rectum. Patient satisfaction is higher with the desogestrel‐only pill than with a vaginal ring.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.1111/aogs.12326</identifier><identifier>PMID: 24372517</identifier><identifier>CODEN: AOGSAE</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Bowel endometriosis ; Contraceptive Devices, Female ; Contraceptives, Oral, Synthetic - administration & dosage ; Contraceptives, Oral, Synthetic - adverse effects ; desogestrel ; Desogestrel - administration & dosage ; Desogestrel - adverse effects ; Desogestrel - analogs & derivatives ; Drug Combinations ; endometriosis ; Endometriosis - complications ; Endometriosis - drug therapy ; Endometriosis - pathology ; Ethinyl Estradiol - administration & dosage ; Ethinyl Estradiol - adverse effects ; Female ; Follow-Up Studies ; hormonal therapy ; Humans ; Patient Satisfaction ; Prospective Studies ; Rectal Diseases - drug therapy ; Rectal Diseases - etiology ; vaginal ring</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 2014-03, Vol.93 (3), p.239-247</ispartof><rights>2013 Nordic Federation of Societies of Obstetrics and Gynecology</rights><rights>2013 Nordic Federation of Societies of Obstetrics and Gynecology.</rights><rights>2014 Nordic Federation of Societies of Obstetrics and Gynecology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4616-426108c32d0b82e471dd8cbf636a10c52ed765bf08542ce5b2a96736d030261c3</citedby><cites>FETCH-LOGICAL-c4616-426108c32d0b82e471dd8cbf636a10c52ed765bf08542ce5b2a96736d030261c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faogs.12326$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faogs.12326$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24372517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leone Roberti Maggiore, Umberto</creatorcontrib><creatorcontrib>Remorgida, Valentino</creatorcontrib><creatorcontrib>Scala, Carolina</creatorcontrib><creatorcontrib>Tafi, Emanuela</creatorcontrib><creatorcontrib>Venturini, Pier L.</creatorcontrib><creatorcontrib>Ferrero, Simone</creatorcontrib><title>Desogestrel-only contraceptive pill versus sequential contraceptive vaginal ring in the treatment of rectovaginal endometriosis infiltrating the rectum: a prospective open-label comparative study</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description>Objective
To compare the efficacy of two hormonal therapies in treating symptoms caused by bowel endometriosis.
Design
Patient preference study.
Setting
University hospital.
Population
A total of 143 women with rectovaginal endometriosis infiltrating the rectum.
Methods
This study was performed between January 2008 and June 2011. Patients were treated with a desogestrel‐only contraceptive pill or with the sequential combined contraceptive vaginal ring for 12 months.
Main outcome measures
The primary endpoint of the study was the rate of satisfied patients at 12‐month follow up. The changes in symptoms and in the volume of the nodules were secondary endpoints.
Results
At 12‐month follow up, the rate of satisfied patients was higher in the group treated with the desogestrel‐only contraceptive pill than in the group treated with the sequential combined contraceptive vaginal ring (p = 0.004). When only changes in gastrointestinal symptoms were considered, 50% of patients treated with the desogestrel‐only contraceptive pill and 31.3% of those treated with the sequential combined contraceptive vaginal ring were satisfied (p = 0.037). The reduction in the volume of the nodules, the percentages of patients who discontinued the therapy after the completion of the study and of those who decided to undergo surgery were similar between the two groups.
Conclusions
Both hormonal therapies are efficacious in treating symptoms caused by rectovaginal endometriosis infiltrating the rectum. Patient satisfaction is higher with the desogestrel‐only pill than with a vaginal ring.</description><subject>Adult</subject><subject>Bowel endometriosis</subject><subject>Contraceptive Devices, Female</subject><subject>Contraceptives, Oral, Synthetic - administration & dosage</subject><subject>Contraceptives, Oral, Synthetic - adverse effects</subject><subject>desogestrel</subject><subject>Desogestrel - administration & dosage</subject><subject>Desogestrel - adverse effects</subject><subject>Desogestrel - analogs & derivatives</subject><subject>Drug Combinations</subject><subject>endometriosis</subject><subject>Endometriosis - complications</subject><subject>Endometriosis - drug therapy</subject><subject>Endometriosis - pathology</subject><subject>Ethinyl Estradiol - administration & dosage</subject><subject>Ethinyl Estradiol - adverse effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>hormonal therapy</subject><subject>Humans</subject><subject>Patient Satisfaction</subject><subject>Prospective Studies</subject><subject>Rectal Diseases - drug therapy</subject><subject>Rectal Diseases - etiology</subject><subject>vaginal ring</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxiMEokvhwgMgS1wQUortOM6GWymwIEor_qncLMeZLG6dONjOwj4fL8aE7fbQA75YM_p933j8ZdljRo8Ynhfar-MR4wWXd7IFk5TmVDB-N1tQSlkuC1EfZA9ivMSKV2J5Pzvgoqh4yapF9uc1RL-GmAK43A9uS4wfUtAGxmQ3QEbrHNlAiFMkEX5OMCSr3S1oo9d2wG6ww5rYgaQfQNBQpx5x4jsSwCS_p2BofQ8pWB9tRLyzDr3SrJ2FMzv1L4kmY_BxxGoe4UcYcqcbmGf3o54F2I5parcPs3uddhEeXd-H2be3b76evMtPz1fvT45PcyMkk7ngktGlKXhLmyUHUbG2XZqmk4XUjJqSQ1vJsunoshTcQNlwXcuqkC0tKEpNcZg92_niw_AnYlK9jQac0wP4KSpWFkJUmEON6NNb6KWfAm6PlKhrQWktBFLPd5TBTWOATo3B9jpsFaNqjlbN0ap_0SL85Npyanpob9B9lgiwHfDLOtj-x0odn6--7E3zncbGBL9vNDpcKVy9KtXF2UqdffwkPr_6fqE-FH8B3zTDWQ</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Leone Roberti Maggiore, Umberto</creator><creator>Remorgida, Valentino</creator><creator>Scala, Carolina</creator><creator>Tafi, Emanuela</creator><creator>Venturini, Pier L.</creator><creator>Ferrero, Simone</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>Desogestrel-only contraceptive pill versus sequential contraceptive vaginal ring in the treatment of rectovaginal endometriosis infiltrating the rectum: a prospective open-label comparative study</title><author>Leone Roberti Maggiore, Umberto ; Remorgida, Valentino ; Scala, Carolina ; Tafi, Emanuela ; Venturini, Pier L. ; Ferrero, Simone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4616-426108c32d0b82e471dd8cbf636a10c52ed765bf08542ce5b2a96736d030261c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Bowel endometriosis</topic><topic>Contraceptive Devices, Female</topic><topic>Contraceptives, Oral, Synthetic - administration & dosage</topic><topic>Contraceptives, Oral, Synthetic - adverse effects</topic><topic>desogestrel</topic><topic>Desogestrel - administration & dosage</topic><topic>Desogestrel - adverse effects</topic><topic>Desogestrel - analogs & derivatives</topic><topic>Drug Combinations</topic><topic>endometriosis</topic><topic>Endometriosis - complications</topic><topic>Endometriosis - drug therapy</topic><topic>Endometriosis - pathology</topic><topic>Ethinyl Estradiol - administration & dosage</topic><topic>Ethinyl Estradiol - adverse effects</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>hormonal therapy</topic><topic>Humans</topic><topic>Patient Satisfaction</topic><topic>Prospective Studies</topic><topic>Rectal Diseases - drug therapy</topic><topic>Rectal Diseases - etiology</topic><topic>vaginal ring</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leone Roberti Maggiore, Umberto</creatorcontrib><creatorcontrib>Remorgida, Valentino</creatorcontrib><creatorcontrib>Scala, Carolina</creatorcontrib><creatorcontrib>Tafi, Emanuela</creatorcontrib><creatorcontrib>Venturini, Pier L.</creatorcontrib><creatorcontrib>Ferrero, Simone</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leone Roberti Maggiore, Umberto</au><au>Remorgida, Valentino</au><au>Scala, Carolina</au><au>Tafi, Emanuela</au><au>Venturini, Pier L.</au><au>Ferrero, Simone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Desogestrel-only contraceptive pill versus sequential contraceptive vaginal ring in the treatment of rectovaginal endometriosis infiltrating the rectum: a prospective open-label comparative study</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>2014-03</date><risdate>2014</risdate><volume>93</volume><issue>3</issue><spage>239</spage><epage>247</epage><pages>239-247</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><coden>AOGSAE</coden><abstract>Objective
To compare the efficacy of two hormonal therapies in treating symptoms caused by bowel endometriosis.
Design
Patient preference study.
Setting
University hospital.
Population
A total of 143 women with rectovaginal endometriosis infiltrating the rectum.
Methods
This study was performed between January 2008 and June 2011. Patients were treated with a desogestrel‐only contraceptive pill or with the sequential combined contraceptive vaginal ring for 12 months.
Main outcome measures
The primary endpoint of the study was the rate of satisfied patients at 12‐month follow up. The changes in symptoms and in the volume of the nodules were secondary endpoints.
Results
At 12‐month follow up, the rate of satisfied patients was higher in the group treated with the desogestrel‐only contraceptive pill than in the group treated with the sequential combined contraceptive vaginal ring (p = 0.004). When only changes in gastrointestinal symptoms were considered, 50% of patients treated with the desogestrel‐only contraceptive pill and 31.3% of those treated with the sequential combined contraceptive vaginal ring were satisfied (p = 0.037). The reduction in the volume of the nodules, the percentages of patients who discontinued the therapy after the completion of the study and of those who decided to undergo surgery were similar between the two groups.
Conclusions
Both hormonal therapies are efficacious in treating symptoms caused by rectovaginal endometriosis infiltrating the rectum. Patient satisfaction is higher with the desogestrel‐only pill than with a vaginal ring.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24372517</pmid><doi>10.1111/aogs.12326</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6349 |
| ispartof | Acta obstetricia et gynecologica Scandinavica, 2014-03, Vol.93 (3), p.239-247 |
| issn | 0001-6349 1600-0412 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Bowel endometriosis Contraceptive Devices, Female Contraceptives, Oral, Synthetic - administration & dosage Contraceptives, Oral, Synthetic - adverse effects desogestrel Desogestrel - administration & dosage Desogestrel - adverse effects Desogestrel - analogs & derivatives Drug Combinations endometriosis Endometriosis - complications Endometriosis - drug therapy Endometriosis - pathology Ethinyl Estradiol - administration & dosage Ethinyl Estradiol - adverse effects Female Follow-Up Studies hormonal therapy Humans Patient Satisfaction Prospective Studies Rectal Diseases - drug therapy Rectal Diseases - etiology vaginal ring |
| title | Desogestrel-only contraceptive pill versus sequential contraceptive vaginal ring in the treatment of rectovaginal endometriosis infiltrating the rectum: a prospective open-label comparative study |
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