Influence of apolipoprotein E, age and aortic site on calcium phosphate induced abdominal aortic aneurysm in mice

Abstract Objective To assess relevant features of abdominal aortic aneurysms (AAA) induced by calcium phosphate within a mouse model. Specifically we investigated: (1) whether apolipoprotein E deficiency and older age promoted AAA formation, and (2) whether the local application of calcium phosphate...

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Veröffentlicht in:	Atherosclerosis 2014-07, Vol.235 (1), p.204-212
Hauptverfasser:	Wang, Yutang, Krishna, Smriti M, Moxon, Joseph, Dinh, Tam Nguyen, Jose, Roby J, Yu, Hongyou, Golledge, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal aortic aneurysm Age Animals Aorta - pathology Aortic Aneurysm, Abdominal - blood Aortic Aneurysm, Abdominal - genetics Apolipoprotein E Apolipoproteins E - blood Apolipoproteins E - genetics Apoptosis Blood Pressure Calcium phosphate Calcium Phosphates - chemistry Cardiovascular Cholesterol Cholesterol - blood Cholesterol, LDL - blood Cholesterol, VLDL - blood Cytokines - metabolism Immunohistochemistry Inflammation Macrophages - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout
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