Lymphadenectomy in surgical stage I epithelial ovarian cancer
Objective To identify the extent of lymphadenectomy performed in women presenting with epithelial ovarian cancer macroscopically confined to the ovary. Furthermore, the effect of lymphadenectomy on overall survival is evaluated. Design A prospective nationwide case‐only study. Setting Denmark 2005–2...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 2014-03, Vol.93 (3), p.256-260 |
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| creator | Svolgaard, Olivia Lidegaard, Øjvind Nielsen, Marie Louise S. Nedergaard, Lotte Mosgaard, Berit J. Lidang, Marianne Mogensen, Ole Kock, Kirsten Blaakær, Jan Stæhr, Estrid Andersen, Erik S. Grove, Anni Høgdall, Claus |
| description | Objective
To identify the extent of lymphadenectomy performed in women presenting with epithelial ovarian cancer macroscopically confined to the ovary. Furthermore, the effect of lymphadenectomy on overall survival is evaluated.
Design
A prospective nationwide case‐only study.
Setting
Denmark 2005–2011.
Sample
All women registered in the nationwide Danish Gynecologic Cancer Database from 1 January 2005 to 1 May 2011, presenting with a tumor macroscopically confined to the ovary without visible evidence of abdominal spread at the time of the initial exploration (surgical stage I).
Method
Descriptive and survival analyses of data from Danish Gynecologic Cancer Database.
Main outcome measures
The annual proportion of women with surgical stage I disease who received lymphadenectomy and the survival in the two groups.
Results
Of 2361 women with epithelial ovarian cancer, 627 were identified with surgical stage I. Lymphadenectomy was performed in 216 women (34%) of whom 13 (6%) had lymph node metastases. At 5‐year follow up 85% remained alive in the lymphadenectomy group compared with 80% in the control group (p = 0.064). The lymphadenectomy fraction increased from 24% in 2005 to 55% in 2011. When univariate and multivariate analyses were conducted only an insignificant difference in the survival probability was found between lymphadenectomy and no lymphadenectomy in women presenting with tumor macroscopically confined to the ovary.
Conclusion
Although increasing, the number of women with surgical stage I disease in Denmark who receive lymphadenectomy remains low, but this did not seem to make a difference to survival. |
| doi_str_mv | 10.1111/aogs.12322 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1534466836</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3222117341</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4972-31bcf4cb13eece6c21a6274c933d2464960c01170a90bdbbc0d3105e8e1cde3d3</originalsourceid><addsrcrecordid>eNp9kE9PGzEQxS1EVQL00g9QrcSlQlqYsR07e-CAopLSRiBBK46W1zsJhv2T2ruFfHtMAxx6YC6jGf3e09Nj7DPCEaY5tt0yHiEXnG-xESqAHCTybTYCAMyVkMUO243xLl1cy8lHtsOllJqDGLGT-bpZ3dqKWnJ916wz32ZxCEvvbJ3F3i4pO89o5ftbqn16dX9t8LbNnG0dhX32YWHrSJ9e9h77ffbt1_R7Pr-cnU9P57mThea5wNItpCtREDlSjqNVKYkrhKi4VLJQ4ABRgy2grMrSQSUQxjQhdBWJSuyxrxvfVej-DBR70_joqK5tS90QDY6FlEpNhErowX_oXTeENqUzKItCAhR6kqjDDeVCF2OghVkF39iwNgjmuVTzXKr5V2qCv7xYDmVD1Rv62mICcAM8-JrW71iZ08vZ9atpvtH42NPjm8aGe6O00GNzczEzmk_x6of8abR4Ahyijy4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1499400978</pqid></control><display><type>article</type><title>Lymphadenectomy in surgical stage I epithelial ovarian cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Svolgaard, Olivia ; Lidegaard, Øjvind ; Nielsen, Marie Louise S. ; Nedergaard, Lotte ; Mosgaard, Berit J. ; Lidang, Marianne ; Mogensen, Ole ; Kock, Kirsten ; Blaakær, Jan ; Stæhr, Estrid ; Andersen, Erik S. ; Grove, Anni ; Høgdall, Claus</creator><creatorcontrib>Svolgaard, Olivia ; Lidegaard, Øjvind ; Nielsen, Marie Louise S. ; Nedergaard, Lotte ; Mosgaard, Berit J. ; Lidang, Marianne ; Mogensen, Ole ; Kock, Kirsten ; Blaakær, Jan ; Stæhr, Estrid ; Andersen, Erik S. ; Grove, Anni ; Høgdall, Claus</creatorcontrib><description>Objective
To identify the extent of lymphadenectomy performed in women presenting with epithelial ovarian cancer macroscopically confined to the ovary. Furthermore, the effect of lymphadenectomy on overall survival is evaluated.
Design
A prospective nationwide case‐only study.
Setting
Denmark 2005–2011.
Sample
All women registered in the nationwide Danish Gynecologic Cancer Database from 1 January 2005 to 1 May 2011, presenting with a tumor macroscopically confined to the ovary without visible evidence of abdominal spread at the time of the initial exploration (surgical stage I).
Method
Descriptive and survival analyses of data from Danish Gynecologic Cancer Database.
Main outcome measures
The annual proportion of women with surgical stage I disease who received lymphadenectomy and the survival in the two groups.
Results
Of 2361 women with epithelial ovarian cancer, 627 were identified with surgical stage I. Lymphadenectomy was performed in 216 women (34%) of whom 13 (6%) had lymph node metastases. At 5‐year follow up 85% remained alive in the lymphadenectomy group compared with 80% in the control group (p = 0.064). The lymphadenectomy fraction increased from 24% in 2005 to 55% in 2011. When univariate and multivariate analyses were conducted only an insignificant difference in the survival probability was found between lymphadenectomy and no lymphadenectomy in women presenting with tumor macroscopically confined to the ovary.
Conclusion
Although increasing, the number of women with surgical stage I disease in Denmark who receive lymphadenectomy remains low, but this did not seem to make a difference to survival.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.1111/aogs.12322</identifier><identifier>PMID: 24447203</identifier><identifier>CODEN: AOGSAE</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Ovarian Epithelial ; Denmark ; Female ; Humans ; lymph node dissection ; Lymph Node Excision - methods ; lymph node metastases ; Lymph Nodes - pathology ; lymphadenectomy ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Staging ; Neoplasms, Glandular and Epithelial - mortality ; Neoplasms, Glandular and Epithelial - pathology ; Neoplasms, Glandular and Epithelial - surgery ; Ovarian cancer ; Ovarian epithelial cancer ; Ovarian Neoplasms - mortality ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - surgery ; Prospective Studies ; Registries ; surgical staging ; Survival Analysis</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 2014-03, Vol.93 (3), p.256-260</ispartof><rights>2013 Nordic Federation of Societies of Obstetrics and Gynecology</rights><rights>2013 Nordic Federation of Societies of Obstetrics and Gynecology.</rights><rights>2014 Nordic Federation of Societies of Obstetrics and Gynecology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4972-31bcf4cb13eece6c21a6274c933d2464960c01170a90bdbbc0d3105e8e1cde3d3</citedby><cites>FETCH-LOGICAL-c4972-31bcf4cb13eece6c21a6274c933d2464960c01170a90bdbbc0d3105e8e1cde3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faogs.12322$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faogs.12322$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24447203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Svolgaard, Olivia</creatorcontrib><creatorcontrib>Lidegaard, Øjvind</creatorcontrib><creatorcontrib>Nielsen, Marie Louise S.</creatorcontrib><creatorcontrib>Nedergaard, Lotte</creatorcontrib><creatorcontrib>Mosgaard, Berit J.</creatorcontrib><creatorcontrib>Lidang, Marianne</creatorcontrib><creatorcontrib>Mogensen, Ole</creatorcontrib><creatorcontrib>Kock, Kirsten</creatorcontrib><creatorcontrib>Blaakær, Jan</creatorcontrib><creatorcontrib>Stæhr, Estrid</creatorcontrib><creatorcontrib>Andersen, Erik S.</creatorcontrib><creatorcontrib>Grove, Anni</creatorcontrib><creatorcontrib>Høgdall, Claus</creatorcontrib><title>Lymphadenectomy in surgical stage I epithelial ovarian cancer</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description>Objective
To identify the extent of lymphadenectomy performed in women presenting with epithelial ovarian cancer macroscopically confined to the ovary. Furthermore, the effect of lymphadenectomy on overall survival is evaluated.
Design
A prospective nationwide case‐only study.
Setting
Denmark 2005–2011.
Sample
All women registered in the nationwide Danish Gynecologic Cancer Database from 1 January 2005 to 1 May 2011, presenting with a tumor macroscopically confined to the ovary without visible evidence of abdominal spread at the time of the initial exploration (surgical stage I).
Method
Descriptive and survival analyses of data from Danish Gynecologic Cancer Database.
Main outcome measures
The annual proportion of women with surgical stage I disease who received lymphadenectomy and the survival in the two groups.
Results
Of 2361 women with epithelial ovarian cancer, 627 were identified with surgical stage I. Lymphadenectomy was performed in 216 women (34%) of whom 13 (6%) had lymph node metastases. At 5‐year follow up 85% remained alive in the lymphadenectomy group compared with 80% in the control group (p = 0.064). The lymphadenectomy fraction increased from 24% in 2005 to 55% in 2011. When univariate and multivariate analyses were conducted only an insignificant difference in the survival probability was found between lymphadenectomy and no lymphadenectomy in women presenting with tumor macroscopically confined to the ovary.
Conclusion
Although increasing, the number of women with surgical stage I disease in Denmark who receive lymphadenectomy remains low, but this did not seem to make a difference to survival.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Ovarian Epithelial</subject><subject>Denmark</subject><subject>Female</subject><subject>Humans</subject><subject>lymph node dissection</subject><subject>Lymph Node Excision - methods</subject><subject>lymph node metastases</subject><subject>Lymph Nodes - pathology</subject><subject>lymphadenectomy</subject><subject>Lymphatic Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Glandular and Epithelial - mortality</subject><subject>Neoplasms, Glandular and Epithelial - pathology</subject><subject>Neoplasms, Glandular and Epithelial - surgery</subject><subject>Ovarian cancer</subject><subject>Ovarian epithelial cancer</subject><subject>Ovarian Neoplasms - mortality</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>surgical staging</subject><subject>Survival Analysis</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PGzEQxS1EVQL00g9QrcSlQlqYsR07e-CAopLSRiBBK46W1zsJhv2T2ruFfHtMAxx6YC6jGf3e09Nj7DPCEaY5tt0yHiEXnG-xESqAHCTybTYCAMyVkMUO243xLl1cy8lHtsOllJqDGLGT-bpZ3dqKWnJ916wz32ZxCEvvbJ3F3i4pO89o5ftbqn16dX9t8LbNnG0dhX32YWHrSJ9e9h77ffbt1_R7Pr-cnU9P57mThea5wNItpCtREDlSjqNVKYkrhKi4VLJQ4ABRgy2grMrSQSUQxjQhdBWJSuyxrxvfVej-DBR70_joqK5tS90QDY6FlEpNhErowX_oXTeENqUzKItCAhR6kqjDDeVCF2OghVkF39iwNgjmuVTzXKr5V2qCv7xYDmVD1Rv62mICcAM8-JrW71iZ08vZ9atpvtH42NPjm8aGe6O00GNzczEzmk_x6of8abR4Ahyijy4</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Svolgaard, Olivia</creator><creator>Lidegaard, Øjvind</creator><creator>Nielsen, Marie Louise S.</creator><creator>Nedergaard, Lotte</creator><creator>Mosgaard, Berit J.</creator><creator>Lidang, Marianne</creator><creator>Mogensen, Ole</creator><creator>Kock, Kirsten</creator><creator>Blaakær, Jan</creator><creator>Stæhr, Estrid</creator><creator>Andersen, Erik S.</creator><creator>Grove, Anni</creator><creator>Høgdall, Claus</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>Lymphadenectomy in surgical stage I epithelial ovarian cancer</title><author>Svolgaard, Olivia ; Lidegaard, Øjvind ; Nielsen, Marie Louise S. ; Nedergaard, Lotte ; Mosgaard, Berit J. ; Lidang, Marianne ; Mogensen, Ole ; Kock, Kirsten ; Blaakær, Jan ; Stæhr, Estrid ; Andersen, Erik S. ; Grove, Anni ; Høgdall, Claus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4972-31bcf4cb13eece6c21a6274c933d2464960c01170a90bdbbc0d3105e8e1cde3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Ovarian Epithelial</topic><topic>Denmark</topic><topic>Female</topic><topic>Humans</topic><topic>lymph node dissection</topic><topic>Lymph Node Excision - methods</topic><topic>lymph node metastases</topic><topic>Lymph Nodes - pathology</topic><topic>lymphadenectomy</topic><topic>Lymphatic Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Glandular and Epithelial - mortality</topic><topic>Neoplasms, Glandular and Epithelial - pathology</topic><topic>Neoplasms, Glandular and Epithelial - surgery</topic><topic>Ovarian cancer</topic><topic>Ovarian epithelial cancer</topic><topic>Ovarian Neoplasms - mortality</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>surgical staging</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Svolgaard, Olivia</creatorcontrib><creatorcontrib>Lidegaard, Øjvind</creatorcontrib><creatorcontrib>Nielsen, Marie Louise S.</creatorcontrib><creatorcontrib>Nedergaard, Lotte</creatorcontrib><creatorcontrib>Mosgaard, Berit J.</creatorcontrib><creatorcontrib>Lidang, Marianne</creatorcontrib><creatorcontrib>Mogensen, Ole</creatorcontrib><creatorcontrib>Kock, Kirsten</creatorcontrib><creatorcontrib>Blaakær, Jan</creatorcontrib><creatorcontrib>Stæhr, Estrid</creatorcontrib><creatorcontrib>Andersen, Erik S.</creatorcontrib><creatorcontrib>Grove, Anni</creatorcontrib><creatorcontrib>Høgdall, Claus</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Svolgaard, Olivia</au><au>Lidegaard, Øjvind</au><au>Nielsen, Marie Louise S.</au><au>Nedergaard, Lotte</au><au>Mosgaard, Berit J.</au><au>Lidang, Marianne</au><au>Mogensen, Ole</au><au>Kock, Kirsten</au><au>Blaakær, Jan</au><au>Stæhr, Estrid</au><au>Andersen, Erik S.</au><au>Grove, Anni</au><au>Høgdall, Claus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphadenectomy in surgical stage I epithelial ovarian cancer</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>2014-03</date><risdate>2014</risdate><volume>93</volume><issue>3</issue><spage>256</spage><epage>260</epage><pages>256-260</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><coden>AOGSAE</coden><abstract>Objective
To identify the extent of lymphadenectomy performed in women presenting with epithelial ovarian cancer macroscopically confined to the ovary. Furthermore, the effect of lymphadenectomy on overall survival is evaluated.
Design
A prospective nationwide case‐only study.
Setting
Denmark 2005–2011.
Sample
All women registered in the nationwide Danish Gynecologic Cancer Database from 1 January 2005 to 1 May 2011, presenting with a tumor macroscopically confined to the ovary without visible evidence of abdominal spread at the time of the initial exploration (surgical stage I).
Method
Descriptive and survival analyses of data from Danish Gynecologic Cancer Database.
Main outcome measures
The annual proportion of women with surgical stage I disease who received lymphadenectomy and the survival in the two groups.
Results
Of 2361 women with epithelial ovarian cancer, 627 were identified with surgical stage I. Lymphadenectomy was performed in 216 women (34%) of whom 13 (6%) had lymph node metastases. At 5‐year follow up 85% remained alive in the lymphadenectomy group compared with 80% in the control group (p = 0.064). The lymphadenectomy fraction increased from 24% in 2005 to 55% in 2011. When univariate and multivariate analyses were conducted only an insignificant difference in the survival probability was found between lymphadenectomy and no lymphadenectomy in women presenting with tumor macroscopically confined to the ovary.
Conclusion
Although increasing, the number of women with surgical stage I disease in Denmark who receive lymphadenectomy remains low, but this did not seem to make a difference to survival.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24447203</pmid><doi>10.1111/aogs.12322</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6349 |
| ispartof | Acta obstetricia et gynecologica Scandinavica, 2014-03, Vol.93 (3), p.256-260 |
| issn | 0001-6349 1600-0412 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1534466836 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Carcinoma, Ovarian Epithelial Denmark Female Humans lymph node dissection Lymph Node Excision - methods lymph node metastases Lymph Nodes - pathology lymphadenectomy Lymphatic Metastasis Middle Aged Neoplasm Staging Neoplasms, Glandular and Epithelial - mortality Neoplasms, Glandular and Epithelial - pathology Neoplasms, Glandular and Epithelial - surgery Ovarian cancer Ovarian epithelial cancer Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Prospective Studies Registries surgical staging Survival Analysis |
| title | Lymphadenectomy in surgical stage I epithelial ovarian cancer |
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