Epicutaneous immunization with protein antigen TNP-Ig and NOD2 ligand muramyl dipeptide (MDP) reverses skin-induced suppression of contact hypersensitivity

Epicutaneous (EC) immunization offers a new method of a needle-free and self-administrable immunization by using a topically applied patch to deliver vaccine. We have previously shown that EC immunization with hapten-conjugated protein antigen TNP-Ig prior to hapten sensitization inhibits Th1-mediat...

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Veröffentlicht in:	Pharmacological reports 2014-02, Vol.66 (1), p.137-142
Hauptverfasser:	Majewska-Szczepanik, Monika, Dorożyńska, Iwona, Strzępa, Anna, Szczepanik, Marian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylmuramyl-Alanyl-Isoglutamine - immunology Animals Contrasuppression Cytokines - biosynthesis Dermatitis, Contact - prevention & control Drug Safety and Pharmacovigilance Epicutaneous immunization Immunization Immunoglobulins - immunology Male Mice Mice, Inbred CBA NOD-like receptors Nod2 Signaling Adaptor Protein - agonists Original Research Article Pharmacotherapy Pharmacy Reversal of suppression Skin - immunology Trinitrobenzenes - immunology
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