Symptom burden and its association with change in glucose metabolism status over a 7-year period: the Hoorn Study
Aims To study symptom burden among older people and its associations with change in glucose metabolism status over a 7‐year period. Methods We conducted a prospective population‐based cohort study among 397 older people. We used the revised Diabetes Symptom Checklist to assess symptom burden. Glucos...
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| Veröffentlicht in: | Diabetic medicine 2014-06, Vol.31 (6), p.747-753 |
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| creator | van der Pols-Vijlbrief, R. Dekker, J. M. Stehouwer, C. D. de Boer, M. R. Nijpels, G. Snoek, F. J. Adriaanse, M. C. |
| description | Aims
To study symptom burden among older people and its associations with change in glucose metabolism status over a 7‐year period.
Methods
We conducted a prospective population‐based cohort study among 397 older people. We used the revised Diabetes Symptom Checklist to assess symptom burden. Glucose metabolism status was determined using an oral glucose tolerance test. Analyses were adjusted for multiple confounders, including cardiovascular risk and risk of depression (Center for Epidemiological Studies Depression Scale score ≥ 16).
Results
Revised Diabetes Symptom Checklist total scores (range 0–100) increased slightly over time among people with normal glucose metabolism (mean difference β1.04; P = 0.04) and those with impaired glucose metabolism (β1.96; P = 0.01), but not among people with Type 2 diabetes (β0.46; P = 0.55). These associations between symptom burden and glucose status were attenuated after full adjustment for multiple confounders and remained statistically significant for those with impaired glucose status. Linear mixed models showed significant mean differences in revised Diabetes Symptom Checklist total scores over time when comparing people with Type 2 diabetes with those with normal or impaired glucose metabolism, but not when comparing subjects with impaired vs normal glucose metabolism; these results did not alter after full adjustment.
Conclusions
Symptom burden increased gradually over time in the people with impaired glucose metabolism and those with normal glucose metabolism, but not in patients with Type 2 diabetes over a 7‐year follow‐up period.
What's new?
This is the first study investigating diabetes‐related symptom burden among older people and its associations with a change in glucose metabolism status over a 7‐year period.
The results indicate that symptom burden increases gradually over time among the participants with impaired glucose and those with normal glucose status, but not among patients with Type 2 diabetes.
Prospective studies are needed in larger populations, including data on comorbidities and information about diabetes treatment, given the potential of treatment to reduce diabetes complications and subsequent symptom burden
. |
| doi_str_mv | 10.1111/dme.12406 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1534269299</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1526131863</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4146-bfd4c46f62e3e1e7fa99c095061a0e62e99bee64c5ad66e50c3e24dccc70cbb53</originalsourceid><addsrcrecordid>eNqN0d9rFDEQB_Agij2rD_4DEpCCPmybX5s0vsm1tsJVH67ax5DNzvZSdzfXJGvd_94971pBEJqXgfCZGYYvQq8pOaTTO6o7OKRMEPkEzaiQoiiFpk_RjCjBCk4U3UMvUrohhDLN9XO0x4TQQmo1Q7fLsVvn0OFqiDX02PY19jlhm1Jw3mYfenzn8wq7le2vAfseX7eDCwlwB9lWofWpwynbPCQcfkLEFqtiBBvxGqIP9QecV4DPQ4g9XuahHl-iZ41tE7za1X307dPp5fy8WHw9-zz_uCicmG4oqqYWTshGMuBAQTVWa0d0SSS1BKZfrSsAKVxpaymhJI4DE7VzThFXVSXfR--2c9cx3A6Qsul8ctC2tocwJENLLpjUTOtHUCYpp8eST_TtP_QmDLGfDtmoUvJSkY16v1UuhpQiNGYdfWfjaCgxm8jMFJn5E9lk3-wmDlUH9YO8z2gCBztgk7NtE23vfPrrjoXSlJHJHW3dnW9h_P9Gc3Jxer-62Hb4lOHXQ4eNP4xUXJXm6suZmV9-l1dkqc2C_wbDvrwI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1525635703</pqid></control><display><type>article</type><title>Symptom burden and its association with change in glucose metabolism status over a 7-year period: the Hoorn Study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>van der Pols-Vijlbrief, R. ; Dekker, J. M. ; Stehouwer, C. D. ; de Boer, M. R. ; Nijpels, G. ; Snoek, F. J. ; Adriaanse, M. C.</creator><creatorcontrib>van der Pols-Vijlbrief, R. ; Dekker, J. M. ; Stehouwer, C. D. ; de Boer, M. R. ; Nijpels, G. ; Snoek, F. J. ; Adriaanse, M. C.</creatorcontrib><description>Aims
To study symptom burden among older people and its associations with change in glucose metabolism status over a 7‐year period.
Methods
We conducted a prospective population‐based cohort study among 397 older people. We used the revised Diabetes Symptom Checklist to assess symptom burden. Glucose metabolism status was determined using an oral glucose tolerance test. Analyses were adjusted for multiple confounders, including cardiovascular risk and risk of depression (Center for Epidemiological Studies Depression Scale score ≥ 16).
Results
Revised Diabetes Symptom Checklist total scores (range 0–100) increased slightly over time among people with normal glucose metabolism (mean difference β1.04; P = 0.04) and those with impaired glucose metabolism (β1.96; P = 0.01), but not among people with Type 2 diabetes (β0.46; P = 0.55). These associations between symptom burden and glucose status were attenuated after full adjustment for multiple confounders and remained statistically significant for those with impaired glucose status. Linear mixed models showed significant mean differences in revised Diabetes Symptom Checklist total scores over time when comparing people with Type 2 diabetes with those with normal or impaired glucose metabolism, but not when comparing subjects with impaired vs normal glucose metabolism; these results did not alter after full adjustment.
Conclusions
Symptom burden increased gradually over time in the people with impaired glucose metabolism and those with normal glucose metabolism, but not in patients with Type 2 diabetes over a 7‐year follow‐up period.
What's new?
This is the first study investigating diabetes‐related symptom burden among older people and its associations with a change in glucose metabolism status over a 7‐year period.
The results indicate that symptom burden increases gradually over time among the participants with impaired glucose and those with normal glucose status, but not among patients with Type 2 diabetes.
Prospective studies are needed in larger populations, including data on comorbidities and information about diabetes treatment, given the potential of treatment to reduce diabetes complications and subsequent symptom burden
.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/dme.12406</identifier><identifier>PMID: 24494697</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Aged ; Biological and medical sciences ; Blood Glucose - metabolism ; Cost of Illness ; Diabetes ; Diabetes Complications - blood ; Diabetes Mellitus, Type 2 - blood ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Glucose ; Glycated Hemoglobin A - metabolism ; Humans ; Insulin ; Male ; Medical sciences ; Metabolism ; Middle Aged ; Older people ; Prospective Studies ; Time Factors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>Diabetic medicine, 2014-06, Vol.31 (6), p.747-753</ispartof><rights>2014 The Authors. Diabetic Medicine © 2014 Diabetes UK</rights><rights>2015 INIST-CNRS</rights><rights>2014 The Authors. Diabetic Medicine © 2014 Diabetes UK.</rights><rights>Diabetic Medicine © 2014 Diabetes UK</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4146-bfd4c46f62e3e1e7fa99c095061a0e62e99bee64c5ad66e50c3e24dccc70cbb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdme.12406$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdme.12406$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28479120$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24494697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Pols-Vijlbrief, R.</creatorcontrib><creatorcontrib>Dekker, J. M.</creatorcontrib><creatorcontrib>Stehouwer, C. D.</creatorcontrib><creatorcontrib>de Boer, M. R.</creatorcontrib><creatorcontrib>Nijpels, G.</creatorcontrib><creatorcontrib>Snoek, F. J.</creatorcontrib><creatorcontrib>Adriaanse, M. C.</creatorcontrib><title>Symptom burden and its association with change in glucose metabolism status over a 7-year period: the Hoorn Study</title><title>Diabetic medicine</title><addtitle>Diabet. Med</addtitle><description>Aims
To study symptom burden among older people and its associations with change in glucose metabolism status over a 7‐year period.
Methods
We conducted a prospective population‐based cohort study among 397 older people. We used the revised Diabetes Symptom Checklist to assess symptom burden. Glucose metabolism status was determined using an oral glucose tolerance test. Analyses were adjusted for multiple confounders, including cardiovascular risk and risk of depression (Center for Epidemiological Studies Depression Scale score ≥ 16).
Results
Revised Diabetes Symptom Checklist total scores (range 0–100) increased slightly over time among people with normal glucose metabolism (mean difference β1.04; P = 0.04) and those with impaired glucose metabolism (β1.96; P = 0.01), but not among people with Type 2 diabetes (β0.46; P = 0.55). These associations between symptom burden and glucose status were attenuated after full adjustment for multiple confounders and remained statistically significant for those with impaired glucose status. Linear mixed models showed significant mean differences in revised Diabetes Symptom Checklist total scores over time when comparing people with Type 2 diabetes with those with normal or impaired glucose metabolism, but not when comparing subjects with impaired vs normal glucose metabolism; these results did not alter after full adjustment.
Conclusions
Symptom burden increased gradually over time in the people with impaired glucose metabolism and those with normal glucose metabolism, but not in patients with Type 2 diabetes over a 7‐year follow‐up period.
What's new?
This is the first study investigating diabetes‐related symptom burden among older people and its associations with a change in glucose metabolism status over a 7‐year period.
The results indicate that symptom burden increases gradually over time among the participants with impaired glucose and those with normal glucose status, but not among patients with Type 2 diabetes.
Prospective studies are needed in larger populations, including data on comorbidities and information about diabetes treatment, given the potential of treatment to reduce diabetes complications and subsequent symptom burden
.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Cost of Illness</subject><subject>Diabetes</subject><subject>Diabetes Complications - blood</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Insulin</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Prospective Studies</subject><subject>Time Factors</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0d9rFDEQB_Agij2rD_4DEpCCPmybX5s0vsm1tsJVH67ax5DNzvZSdzfXJGvd_94971pBEJqXgfCZGYYvQq8pOaTTO6o7OKRMEPkEzaiQoiiFpk_RjCjBCk4U3UMvUrohhDLN9XO0x4TQQmo1Q7fLsVvn0OFqiDX02PY19jlhm1Jw3mYfenzn8wq7le2vAfseX7eDCwlwB9lWofWpwynbPCQcfkLEFqtiBBvxGqIP9QecV4DPQ4g9XuahHl-iZ41tE7za1X307dPp5fy8WHw9-zz_uCicmG4oqqYWTshGMuBAQTVWa0d0SSS1BKZfrSsAKVxpaymhJI4DE7VzThFXVSXfR--2c9cx3A6Qsul8ctC2tocwJENLLpjUTOtHUCYpp8eST_TtP_QmDLGfDtmoUvJSkY16v1UuhpQiNGYdfWfjaCgxm8jMFJn5E9lk3-wmDlUH9YO8z2gCBztgk7NtE23vfPrrjoXSlJHJHW3dnW9h_P9Gc3Jxer-62Hb4lOHXQ4eNP4xUXJXm6suZmV9-l1dkqc2C_wbDvrwI</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>van der Pols-Vijlbrief, R.</creator><creator>Dekker, J. M.</creator><creator>Stehouwer, C. D.</creator><creator>de Boer, M. R.</creator><creator>Nijpels, G.</creator><creator>Snoek, F. J.</creator><creator>Adriaanse, M. C.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope></search><sort><creationdate>201406</creationdate><title>Symptom burden and its association with change in glucose metabolism status over a 7-year period: the Hoorn Study</title><author>van der Pols-Vijlbrief, R. ; Dekker, J. M. ; Stehouwer, C. D. ; de Boer, M. R. ; Nijpels, G. ; Snoek, F. J. ; Adriaanse, M. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4146-bfd4c46f62e3e1e7fa99c095061a0e62e99bee64c5ad66e50c3e24dccc70cbb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Cost of Illness</topic><topic>Diabetes</topic><topic>Diabetes Complications - blood</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Insulin</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Prospective Studies</topic><topic>Time Factors</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Pols-Vijlbrief, R.</creatorcontrib><creatorcontrib>Dekker, J. M.</creatorcontrib><creatorcontrib>Stehouwer, C. D.</creatorcontrib><creatorcontrib>de Boer, M. R.</creatorcontrib><creatorcontrib>Nijpels, G.</creatorcontrib><creatorcontrib>Snoek, F. J.</creatorcontrib><creatorcontrib>Adriaanse, M. C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Pols-Vijlbrief, R.</au><au>Dekker, J. M.</au><au>Stehouwer, C. D.</au><au>de Boer, M. R.</au><au>Nijpels, G.</au><au>Snoek, F. J.</au><au>Adriaanse, M. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Symptom burden and its association with change in glucose metabolism status over a 7-year period: the Hoorn Study</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet. Med</addtitle><date>2014-06</date><risdate>2014</risdate><volume>31</volume><issue>6</issue><spage>747</spage><epage>753</epage><pages>747-753</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aims
To study symptom burden among older people and its associations with change in glucose metabolism status over a 7‐year period.
Methods
We conducted a prospective population‐based cohort study among 397 older people. We used the revised Diabetes Symptom Checklist to assess symptom burden. Glucose metabolism status was determined using an oral glucose tolerance test. Analyses were adjusted for multiple confounders, including cardiovascular risk and risk of depression (Center for Epidemiological Studies Depression Scale score ≥ 16).
Results
Revised Diabetes Symptom Checklist total scores (range 0–100) increased slightly over time among people with normal glucose metabolism (mean difference β1.04; P = 0.04) and those with impaired glucose metabolism (β1.96; P = 0.01), but not among people with Type 2 diabetes (β0.46; P = 0.55). These associations between symptom burden and glucose status were attenuated after full adjustment for multiple confounders and remained statistically significant for those with impaired glucose status. Linear mixed models showed significant mean differences in revised Diabetes Symptom Checklist total scores over time when comparing people with Type 2 diabetes with those with normal or impaired glucose metabolism, but not when comparing subjects with impaired vs normal glucose metabolism; these results did not alter after full adjustment.
Conclusions
Symptom burden increased gradually over time in the people with impaired glucose metabolism and those with normal glucose metabolism, but not in patients with Type 2 diabetes over a 7‐year follow‐up period.
What's new?
This is the first study investigating diabetes‐related symptom burden among older people and its associations with a change in glucose metabolism status over a 7‐year period.
The results indicate that symptom burden increases gradually over time among the participants with impaired glucose and those with normal glucose status, but not among patients with Type 2 diabetes.
Prospective studies are needed in larger populations, including data on comorbidities and information about diabetes treatment, given the potential of treatment to reduce diabetes complications and subsequent symptom burden
.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>24494697</pmid><doi>10.1111/dme.12406</doi><tpages>7</tpages></addata></record> |
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| ispartof | Diabetic medicine, 2014-06, Vol.31 (6), p.747-753 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Biological and medical sciences Blood Glucose - metabolism Cost of Illness Diabetes Diabetes Complications - blood Diabetes Mellitus, Type 2 - blood Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Glucose Glycated Hemoglobin A - metabolism Humans Insulin Male Medical sciences Metabolism Middle Aged Older people Prospective Studies Time Factors Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Symptom burden and its association with change in glucose metabolism status over a 7-year period: the Hoorn Study |
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