Metal-Free Azaphosphaannulation of Phosphonamides through Intramolecular Oxidative C–N Bond Formation

Metal-Free Azaphosphaannulation of Phosphonamides through Intramolecular Oxidative C–N Bond Formation

We report an efficient metal-free azaphosphaannulation of a myriad of phosphonamides through intramolecular oxidative C–N bond formation using PhI­(OAc)2 and iodine in acetonitrile under air, thus leading to the formation of benzazaphosphol-3-one 1-oxides, which are novel phosphorus heterocyclic pri...

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Veröffentlicht in:Organic letters 2014-06, Vol.16 (11), p.3098-3101
Hauptverfasser: Kim, Yea Rin, Cho, Seungyoon, Lee, Phil Ho
Format: Artikel
Sprache:eng
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Zusammenfassung:We report an efficient metal-free azaphosphaannulation of a myriad of phosphonamides through intramolecular oxidative C–N bond formation using PhI­(OAc)2 and iodine in acetonitrile under air, thus leading to the formation of benzazaphosphol-3-one 1-oxides, which are novel phosphorus heterocyclic privileged structures.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol501207w