Risk factors for deterioration of nodular bronchiectatic Mycobacterium avium complex lung disease
SETTINGThe long-term natural course of Mycobacterium avium complex (MAC) disease with nodular bronchiectasis, the most common pulmonary non-tuberculous mycobacterial disease, is not well described. OBJECTIVE:To identify risk factors for the deterioration of nodular bronchiectatic MAC lung disease ov...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2014-06, Vol.18 (6), p.730-736 |
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| container_title | The international journal of tuberculosis and lung disease |
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| creator | Kim, S. J. Park, J. Lee, H. Lee, Y. J. Park, J. S. Cho, Y-J. Yoon, H. I. Lee, C-T. Lee, J. H. |
| description | SETTINGThe long-term natural course of Mycobacterium avium complex (MAC) disease with nodular bronchiectasis, the most common pulmonary non-tuberculous mycobacterial disease, is not well described.
OBJECTIVE:To identify risk factors for the deterioration of nodular bronchiectatic MAC lung disease over a 5-year follow-up period. DESIGN:Clinical and laboratory data
of 67 patients with nodular bronchiectatic MAC lung disease were collected. Chest computerised tomographic images were used to count the number of lung segments involved at diagnosis and measure subcutaneous fat thickness during follow-up. RESULTS:
The 34 patients who showed deterioration had significantly lower body mass index (BMI) (P = 0.004) and % predicted forced vital capacity (P = 0.032), higher numbers of lung segments involved (P < 0.001) and MAC-positive sputum cultures (P = 0.028), and
thinner chest subcutaneous fat during follow-up (P < 0.001) than patients without deterioration. In particular, patients with both BMI |
| doi_str_mv | 10.5588/ijtld.13.0792 |
| format | Article |
| fullrecord | <record><control><sourceid>pubtec_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1534098534</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ingid>iuatld/ijtld/2014/00000018/00000006/art00019</ingid><sourcerecordid>iuatld/ijtld/2014/00000018/00000006/art00019</sourcerecordid><originalsourceid>FETCH-LOGICAL-c557t-c150598a68b5e6056d774695640829efbf53edc9ac508d05d2cdb779bb5ec9cf3</originalsourceid><addsrcrecordid>eNqNkktv1DAQgCMEoqVw5Ip8QeKSxXbi1xG1UJCKEAjOluPH4iWxFz8qyq-v093CCQkfxiP78zfSjLvuOYIbQjh_7XdlNhs0bCAT-EF3ijgifUvhw5ZDzPqBIXHSPcl5ByFGCLHH3QkeBRzESE879cXnH8ApXWLKwMUEjC02-ZhU8TGA6ECIps4qgSnFoL97q0u70uDjjY5Te9fgugB1vUYdl_1sf4G5hi0wPluV7dPukVNzts-O-1n37d3br-fv-6tPlx_O31z1mhBWeo0IJIIryidiKSTUMDZSQegIORbWTY4M1mihNIHcQGKwNhNjYmq4FtoNZ92rg3ef4s9qc5GLz9rOswo21iwRIYhiwjD-D3QYoeAtNrQ_oDrFnJN1cp_8otKNRFCuA5B3A5BokOsAGv_iqK7TYs0f-r7jDXh5BFTWanZJBe3zX46PfKB05S4OnA9bG4qSu1hTaA2Uvqq14qEuhmiU8G4hfkwglSqV9UQ0zed_afS9af0m6y-R14gH2pQYtZ4TiUbCpbFO1bnIopLc_pa5OW8BuQHBYQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1534098534</pqid></control><display><type>article</type><title>Risk factors for deterioration of nodular bronchiectatic Mycobacterium avium complex lung disease</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kim, S. J. ; Park, J. ; Lee, H. ; Lee, Y. J. ; Park, J. S. ; Cho, Y-J. ; Yoon, H. I. ; Lee, C-T. ; Lee, J. H.</creator><creatorcontrib>Kim, S. J. ; Park, J. ; Lee, H. ; Lee, Y. J. ; Park, J. S. ; Cho, Y-J. ; Yoon, H. I. ; Lee, C-T. ; Lee, J. H.</creatorcontrib><description>SETTINGThe long-term natural course of Mycobacterium avium complex (MAC) disease with nodular bronchiectasis, the most common pulmonary non-tuberculous mycobacterial disease, is not well described.
OBJECTIVE:To identify risk factors for the deterioration of nodular bronchiectatic MAC lung disease over a 5-year follow-up period. DESIGN:Clinical and laboratory data
of 67 patients with nodular bronchiectatic MAC lung disease were collected. Chest computerised tomographic images were used to count the number of lung segments involved at diagnosis and measure subcutaneous fat thickness during follow-up. RESULTS:
The 34 patients who showed deterioration had significantly lower body mass index (BMI) (P = 0.004) and % predicted forced vital capacity (P = 0.032), higher numbers of lung segments involved (P < 0.001) and MAC-positive sputum cultures (P = 0.028), and
thinner chest subcutaneous fat during follow-up (P < 0.001) than patients without deterioration. In particular, patients with both BMI <21.0 kg/m2 and more than four lung segments involved had a 240-fold increased risk of deterioration (P < 0.001).
CONCLUSION:Patients with poor nutritional status and extensive lung involvement tend to experience deterioration of nodular bronchiectatic MAC lung disease.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>DOI: 10.5588/ijtld.13.0792</identifier><identifier>PMID: 24903946</identifier><language>eng</language><publisher>Paris: International Union Against Tuberculosis and Lung Disease</publisher><subject>Aged ; Bacterial diseases ; Bacteriological Techniques ; Biological and medical sciences ; Body Mass Index ; Bronchiectasis ; Bronchiectasis - diagnosis ; Bronchiectasis - microbiology ; Bronchiectasis - physiopathology ; Disease Progression ; Female ; Forced Expiratory Volume ; Human bacterial diseases ; Humans ; Infectious diseases ; Lung - diagnostic imaging ; Lung - microbiology ; Lung - physiopathology ; M. Avium Complex ; Male ; Medical sciences ; Middle Aged ; Mycobacterium avium ; Mycobacterium avium Complex - isolation & purification ; Mycobacterium avium-intracellulare Infection - complications ; Mycobacterium avium-intracellulare Infection - diagnosis ; Mycobacterium avium-intracellulare Infection - microbiology ; Mycobacterium avium-intracellulare Infection - physiopathology ; Nutrition ; Nutritional Status ; Pneumology ; Predictive Value of Tests ; Registries ; Respiratory system : syndromes and miscellaneous diseases ; Risk Factors ; Spirometry ; Sputum - microbiology ; Subcutaneous Fat ; Subcutaneous Fat - diagnostic imaging ; Time Factors ; Tomography, X-Ray Computed ; Tuberculosis and atypical mycobacterial infections ; Vital Capacity</subject><ispartof>The international journal of tuberculosis and lung disease, 2014-06, Vol.18 (6), p.730-736</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-c150598a68b5e6056d774695640829efbf53edc9ac508d05d2cdb779bb5ec9cf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28483666$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24903946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, S. J.</creatorcontrib><creatorcontrib>Park, J.</creatorcontrib><creatorcontrib>Lee, H.</creatorcontrib><creatorcontrib>Lee, Y. J.</creatorcontrib><creatorcontrib>Park, J. S.</creatorcontrib><creatorcontrib>Cho, Y-J.</creatorcontrib><creatorcontrib>Yoon, H. I.</creatorcontrib><creatorcontrib>Lee, C-T.</creatorcontrib><creatorcontrib>Lee, J. H.</creatorcontrib><title>Risk factors for deterioration of nodular bronchiectatic Mycobacterium avium complex lung disease</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>SETTINGThe long-term natural course of Mycobacterium avium complex (MAC) disease with nodular bronchiectasis, the most common pulmonary non-tuberculous mycobacterial disease, is not well described.
OBJECTIVE:To identify risk factors for the deterioration of nodular bronchiectatic MAC lung disease over a 5-year follow-up period. DESIGN:Clinical and laboratory data
of 67 patients with nodular bronchiectatic MAC lung disease were collected. Chest computerised tomographic images were used to count the number of lung segments involved at diagnosis and measure subcutaneous fat thickness during follow-up. RESULTS:
The 34 patients who showed deterioration had significantly lower body mass index (BMI) (P = 0.004) and % predicted forced vital capacity (P = 0.032), higher numbers of lung segments involved (P < 0.001) and MAC-positive sputum cultures (P = 0.028), and
thinner chest subcutaneous fat during follow-up (P < 0.001) than patients without deterioration. In particular, patients with both BMI <21.0 kg/m2 and more than four lung segments involved had a 240-fold increased risk of deterioration (P < 0.001).
CONCLUSION:Patients with poor nutritional status and extensive lung involvement tend to experience deterioration of nodular bronchiectatic MAC lung disease.</description><subject>Aged</subject><subject>Bacterial diseases</subject><subject>Bacteriological Techniques</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Bronchiectasis</subject><subject>Bronchiectasis - diagnosis</subject><subject>Bronchiectasis - microbiology</subject><subject>Bronchiectasis - physiopathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - microbiology</subject><subject>Lung - physiopathology</subject><subject>M. Avium Complex</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycobacterium avium</subject><subject>Mycobacterium avium Complex - isolation & purification</subject><subject>Mycobacterium avium-intracellulare Infection - complications</subject><subject>Mycobacterium avium-intracellulare Infection - diagnosis</subject><subject>Mycobacterium avium-intracellulare Infection - microbiology</subject><subject>Mycobacterium avium-intracellulare Infection - physiopathology</subject><subject>Nutrition</subject><subject>Nutritional Status</subject><subject>Pneumology</subject><subject>Predictive Value of Tests</subject><subject>Registries</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Risk Factors</subject><subject>Spirometry</subject><subject>Sputum - microbiology</subject><subject>Subcutaneous Fat</subject><subject>Subcutaneous Fat - diagnostic imaging</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Vital Capacity</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktv1DAQgCMEoqVw5Ip8QeKSxXbi1xG1UJCKEAjOluPH4iWxFz8qyq-v093CCQkfxiP78zfSjLvuOYIbQjh_7XdlNhs0bCAT-EF3ijgifUvhw5ZDzPqBIXHSPcl5ByFGCLHH3QkeBRzESE879cXnH8ApXWLKwMUEjC02-ZhU8TGA6ECIps4qgSnFoL97q0u70uDjjY5Te9fgugB1vUYdl_1sf4G5hi0wPluV7dPukVNzts-O-1n37d3br-fv-6tPlx_O31z1mhBWeo0IJIIryidiKSTUMDZSQegIORbWTY4M1mihNIHcQGKwNhNjYmq4FtoNZ92rg3ef4s9qc5GLz9rOswo21iwRIYhiwjD-D3QYoeAtNrQ_oDrFnJN1cp_8otKNRFCuA5B3A5BokOsAGv_iqK7TYs0f-r7jDXh5BFTWanZJBe3zX46PfKB05S4OnA9bG4qSu1hTaA2Uvqq14qEuhmiU8G4hfkwglSqV9UQ0zed_afS9af0m6y-R14gH2pQYtZ4TiUbCpbFO1bnIopLc_pa5OW8BuQHBYQ</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Kim, S. J.</creator><creator>Park, J.</creator><creator>Lee, H.</creator><creator>Lee, Y. J.</creator><creator>Park, J. S.</creator><creator>Cho, Y-J.</creator><creator>Yoon, H. I.</creator><creator>Lee, C-T.</creator><creator>Lee, J. H.</creator><general>International Union Against Tuberculosis and Lung Disease</general><general>International Union against Tuberculosis and Lung Disease</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20140601</creationdate><title>Risk factors for deterioration of nodular bronchiectatic Mycobacterium avium complex lung disease</title><author>Kim, S. J. ; Park, J. ; Lee, H. ; Lee, Y. J. ; Park, J. S. ; Cho, Y-J. ; Yoon, H. I. ; Lee, C-T. ; Lee, J. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-c150598a68b5e6056d774695640829efbf53edc9ac508d05d2cdb779bb5ec9cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Bacterial diseases</topic><topic>Bacteriological Techniques</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Bronchiectasis</topic><topic>Bronchiectasis - diagnosis</topic><topic>Bronchiectasis - microbiology</topic><topic>Bronchiectasis - physiopathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - microbiology</topic><topic>Lung - physiopathology</topic><topic>M. Avium Complex</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mycobacterium avium</topic><topic>Mycobacterium avium Complex - isolation & purification</topic><topic>Mycobacterium avium-intracellulare Infection - complications</topic><topic>Mycobacterium avium-intracellulare Infection - diagnosis</topic><topic>Mycobacterium avium-intracellulare Infection - microbiology</topic><topic>Mycobacterium avium-intracellulare Infection - physiopathology</topic><topic>Nutrition</topic><topic>Nutritional Status</topic><topic>Pneumology</topic><topic>Predictive Value of Tests</topic><topic>Registries</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Risk Factors</topic><topic>Spirometry</topic><topic>Sputum - microbiology</topic><topic>Subcutaneous Fat</topic><topic>Subcutaneous Fat - diagnostic imaging</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, S. J.</creatorcontrib><creatorcontrib>Park, J.</creatorcontrib><creatorcontrib>Lee, H.</creatorcontrib><creatorcontrib>Lee, Y. J.</creatorcontrib><creatorcontrib>Park, J. S.</creatorcontrib><creatorcontrib>Cho, Y-J.</creatorcontrib><creatorcontrib>Yoon, H. I.</creatorcontrib><creatorcontrib>Lee, C-T.</creatorcontrib><creatorcontrib>Lee, J. H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, S. J.</au><au>Park, J.</au><au>Lee, H.</au><au>Lee, Y. J.</au><au>Park, J. S.</au><au>Cho, Y-J.</au><au>Yoon, H. I.</au><au>Lee, C-T.</au><au>Lee, J. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for deterioration of nodular bronchiectatic Mycobacterium avium complex lung disease</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>18</volume><issue>6</issue><spage>730</spage><epage>736</epage><pages>730-736</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>SETTINGThe long-term natural course of Mycobacterium avium complex (MAC) disease with nodular bronchiectasis, the most common pulmonary non-tuberculous mycobacterial disease, is not well described.
OBJECTIVE:To identify risk factors for the deterioration of nodular bronchiectatic MAC lung disease over a 5-year follow-up period. DESIGN:Clinical and laboratory data
of 67 patients with nodular bronchiectatic MAC lung disease were collected. Chest computerised tomographic images were used to count the number of lung segments involved at diagnosis and measure subcutaneous fat thickness during follow-up. RESULTS:
The 34 patients who showed deterioration had significantly lower body mass index (BMI) (P = 0.004) and % predicted forced vital capacity (P = 0.032), higher numbers of lung segments involved (P < 0.001) and MAC-positive sputum cultures (P = 0.028), and
thinner chest subcutaneous fat during follow-up (P < 0.001) than patients without deterioration. In particular, patients with both BMI <21.0 kg/m2 and more than four lung segments involved had a 240-fold increased risk of deterioration (P < 0.001).
CONCLUSION:Patients with poor nutritional status and extensive lung involvement tend to experience deterioration of nodular bronchiectatic MAC lung disease.</abstract><cop>Paris</cop><pub>International Union Against Tuberculosis and Lung Disease</pub><pmid>24903946</pmid><doi>10.5588/ijtld.13.0792</doi><tpages>7</tpages></addata></record> |
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| ispartof | The international journal of tuberculosis and lung disease, 2014-06, Vol.18 (6), p.730-736 |
| issn | 1027-3719 1815-7920 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Bacterial diseases Bacteriological Techniques Biological and medical sciences Body Mass Index Bronchiectasis Bronchiectasis - diagnosis Bronchiectasis - microbiology Bronchiectasis - physiopathology Disease Progression Female Forced Expiratory Volume Human bacterial diseases Humans Infectious diseases Lung - diagnostic imaging Lung - microbiology Lung - physiopathology M. Avium Complex Male Medical sciences Middle Aged Mycobacterium avium Mycobacterium avium Complex - isolation & purification Mycobacterium avium-intracellulare Infection - complications Mycobacterium avium-intracellulare Infection - diagnosis Mycobacterium avium-intracellulare Infection - microbiology Mycobacterium avium-intracellulare Infection - physiopathology Nutrition Nutritional Status Pneumology Predictive Value of Tests Registries Respiratory system : syndromes and miscellaneous diseases Risk Factors Spirometry Sputum - microbiology Subcutaneous Fat Subcutaneous Fat - diagnostic imaging Time Factors Tomography, X-Ray Computed Tuberculosis and atypical mycobacterial infections Vital Capacity |
| title | Risk factors for deterioration of nodular bronchiectatic Mycobacterium avium complex lung disease |
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