Effect of dose of sodium saccharin on the induction of rat urinary bladder proliferation

The effect of sodium saccharin fed to male F344 rats at levels of 5.0, 2.5, 1.0, 0.5, and 0.1% of the diet for 10 weeks was evaluated by autoradiography and scanning electron microscopy. A dose response was evident with both techniques. The labeling index was statistically significantly elevated at...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1981-03, Vol.41 (3), p.942-944
Hauptverfasser:	Murasaki, G, Cohen, S M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autoradiography cancer Dose-Response Relationship, Drug Hyperplasia Male microscopy Microscopy, Electron, Scanning radiology Rats Saccharin - toxicity sodium saccharin statistical analysis Urinary Bladder Diseases - chemically induced Urinary Bladder Diseases - pathology
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