Cigarette sidestream smoke induces histone H3 phosphorylation via JNK and PI3K/Akt pathways, leading to the expression of proto-oncogenes

Post-translational modifications in histones have been associated with cancer. Although cigarette sidestream smoke (CSS) as well as mainstream smoke are carcinogens, the relationship between carcinogenicity and histone modifications has not yet been clarified. Here, we demonstrated that CSS induced...

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Veröffentlicht in:	Carcinogenesis (New York) 2014-06, Vol.35 (6), p.1228-1237
Hauptverfasser:	Ibuki, Yuko, Toyooka, Tatsushi, Zhao, Xiaoxu, Yoshida, Ikuma
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor DNA Damage Gene Expression Regulation, Neoplastic Histones - metabolism Humans JNK Mitogen-Activated Protein Kinases - metabolism MAP Kinase Signaling System Neoplasms - etiology Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-jun - genetics Proto-Oncogenes - genetics Signal Transduction Tobacco Smoke Pollution - adverse effects Transcriptional Activation
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