Antioxidant status in patients with psoriasis
Psoriasis is a chronic inflammatory skin disease with an unknown aetiology that has been associated with abnormal plasma lipid metabolism and oxidative stress. There are controversial results in the previous studies investigating oxidant/antioxidant systems in psoriasis. The aim of this work was to...
Gespeichert in:
| Veröffentlicht in: | Cell biochemistry and function 2014-04, Vol.32 (3), p.268-273 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 273 |
|---|---|
| container_issue | 3 |
| container_start_page | 268 |
| container_title | Cell biochemistry and function |
| container_volume | 32 |
| creator | Houshang, Nemati Reza, Khodarahmi Masoud, Sadeghi Ali, Ebrahimi Mansour, Rezaei Vaisi‐Raygani, Asad |
| description | Psoriasis is a chronic inflammatory skin disease with an unknown aetiology that has been associated with abnormal plasma lipid metabolism and oxidative stress. There are controversial results in the previous studies investigating oxidant/antioxidant systems in psoriasis.
The aim of this work was to evaluate the plasma levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total bilirubin (T. Bili), direct bilirubin (D. Bili), uric acid (UA), apolipoproteins (ApoA1 and ApoB), Lp(a) and activities of paraxonase 1 (PON1) in 100 patients with psoriasis and 100 controls, and to look for a correlation between these parameters in psoriasis.
PON1, bilirubin and UA were measured spectrophotometrically, MDA by the high‐performance liquid chromatography method, apolipoproteins and Lp(a) by immunoprecipitation assays, and lipid and other biochemical parameters were determined by routine laboratory methods.
In patients with psoriasis, there was a significant decrease in PON1, SOD and CAT activities (P |
| doi_str_mv | 10.1002/cbf.3011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1532949669</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1532949669</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3491-4195b50f0354d8a03a08fd02f3d43c89b2a4feef7f4f9e3f6e5eaa449e98c6243</originalsourceid><addsrcrecordid>eNp10E9LwzAYx_EgiptT8BVIwYuXzCfNk9gc53AqDLzoOaRtghldW5uUuXdv5_wDgqfn8uHLw4-QcwZTBpBeF7mbcmDsgIwZKEUhQzwkY0glpxIzHJGTEFYAoCSHYzJKMVNCKjkmdFZH37z70tQxCdHEPiS-TloTva1jSDY-viZtaDpvgg-n5MiZKtizrzshL4u75_kDXT7dP85nS1pwVIwiUyIX4IALLDMD3EDmSkgdL5EXmcpTg85ad-PQKcudtMIag6isygqZIp-Qq3237Zq33oao1z4UtqpMbZs-aCZ4qlBJqQZ6-Yeumr6rh-8GxZCDFAJ-g0XXhNBZp9vOr0231Qz0bkI9TKh3Ew704ivY52tb_sDvzQZA92DjK7v9N6Tnt4vP4AfZF3hT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1514306550</pqid></control><display><type>article</type><title>Antioxidant status in patients with psoriasis</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Houshang, Nemati ; Reza, Khodarahmi ; Masoud, Sadeghi ; Ali, Ebrahimi ; Mansour, Rezaei ; Vaisi‐Raygani, Asad</creator><creatorcontrib>Houshang, Nemati ; Reza, Khodarahmi ; Masoud, Sadeghi ; Ali, Ebrahimi ; Mansour, Rezaei ; Vaisi‐Raygani, Asad</creatorcontrib><description>Psoriasis is a chronic inflammatory skin disease with an unknown aetiology that has been associated with abnormal plasma lipid metabolism and oxidative stress. There are controversial results in the previous studies investigating oxidant/antioxidant systems in psoriasis.
The aim of this work was to evaluate the plasma levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total bilirubin (T. Bili), direct bilirubin (D. Bili), uric acid (UA), apolipoproteins (ApoA1 and ApoB), Lp(a) and activities of paraxonase 1 (PON1) in 100 patients with psoriasis and 100 controls, and to look for a correlation between these parameters in psoriasis.
PON1, bilirubin and UA were measured spectrophotometrically, MDA by the high‐performance liquid chromatography method, apolipoproteins and Lp(a) by immunoprecipitation assays, and lipid and other biochemical parameters were determined by routine laboratory methods.
In patients with psoriasis, there was a significant decrease in PON1, SOD and CAT activities (P < 0.05) and an increase in MDA levels (P < 0.01). Also, the levels of bilirubin (total and direct) and UA were decreased in patients with psoriasis but were not significant (P > 0.05).
These results suggest that psoriasis was in a state of oxidative stress and that the protective effects of high‐density lipoprotein against atherosclerosis may be dependent on PON1 activity. Moreover, there is a negative correlation between antioxidant with Lp(a), apoB and MDA levels, suggesting that subjects with higher levels of Lp(a) and apoB and lower levels of antioxidant are more exposed to oxidative damage. These findings may explain in part the reported increase in cardiovascular mortality in psoriasis. Copyright © 2013 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0263-6484</identifier><identifier>EISSN: 1099-0844</identifier><identifier>DOI: 10.1002/cbf.3011</identifier><identifier>PMID: 24895696</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; antioxidant ; Antioxidants - metabolism ; Apolipoprotein A-I - blood ; apolipoproteins ; Apolipoproteins B - blood ; Aryldialkylphosphatase - blood ; Bilirubin - blood ; Case-Control Studies ; Catalase - blood ; Female ; Humans ; lipids ; Male ; Middle Aged ; oxidant ; Oxidation-Reduction ; Oxidative Stress ; psoriasis ; Psoriasis - blood ; Superoxide Dismutase - blood ; Uric Acid - blood ; Young Adult</subject><ispartof>Cell biochemistry and function, 2014-04, Vol.32 (3), p.268-273</ispartof><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3491-4195b50f0354d8a03a08fd02f3d43c89b2a4feef7f4f9e3f6e5eaa449e98c6243</citedby><cites>FETCH-LOGICAL-c3491-4195b50f0354d8a03a08fd02f3d43c89b2a4feef7f4f9e3f6e5eaa449e98c6243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbf.3011$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbf.3011$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24895696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Houshang, Nemati</creatorcontrib><creatorcontrib>Reza, Khodarahmi</creatorcontrib><creatorcontrib>Masoud, Sadeghi</creatorcontrib><creatorcontrib>Ali, Ebrahimi</creatorcontrib><creatorcontrib>Mansour, Rezaei</creatorcontrib><creatorcontrib>Vaisi‐Raygani, Asad</creatorcontrib><title>Antioxidant status in patients with psoriasis</title><title>Cell biochemistry and function</title><addtitle>Cell Biochem Funct</addtitle><description>Psoriasis is a chronic inflammatory skin disease with an unknown aetiology that has been associated with abnormal plasma lipid metabolism and oxidative stress. There are controversial results in the previous studies investigating oxidant/antioxidant systems in psoriasis.
The aim of this work was to evaluate the plasma levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total bilirubin (T. Bili), direct bilirubin (D. Bili), uric acid (UA), apolipoproteins (ApoA1 and ApoB), Lp(a) and activities of paraxonase 1 (PON1) in 100 patients with psoriasis and 100 controls, and to look for a correlation between these parameters in psoriasis.
PON1, bilirubin and UA were measured spectrophotometrically, MDA by the high‐performance liquid chromatography method, apolipoproteins and Lp(a) by immunoprecipitation assays, and lipid and other biochemical parameters were determined by routine laboratory methods.
In patients with psoriasis, there was a significant decrease in PON1, SOD and CAT activities (P < 0.05) and an increase in MDA levels (P < 0.01). Also, the levels of bilirubin (total and direct) and UA were decreased in patients with psoriasis but were not significant (P > 0.05).
These results suggest that psoriasis was in a state of oxidative stress and that the protective effects of high‐density lipoprotein against atherosclerosis may be dependent on PON1 activity. Moreover, there is a negative correlation between antioxidant with Lp(a), apoB and MDA levels, suggesting that subjects with higher levels of Lp(a) and apoB and lower levels of antioxidant are more exposed to oxidative damage. These findings may explain in part the reported increase in cardiovascular mortality in psoriasis. Copyright © 2013 John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>antioxidant</subject><subject>Antioxidants - metabolism</subject><subject>Apolipoprotein A-I - blood</subject><subject>apolipoproteins</subject><subject>Apolipoproteins B - blood</subject><subject>Aryldialkylphosphatase - blood</subject><subject>Bilirubin - blood</subject><subject>Case-Control Studies</subject><subject>Catalase - blood</subject><subject>Female</subject><subject>Humans</subject><subject>lipids</subject><subject>Male</subject><subject>Middle Aged</subject><subject>oxidant</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>psoriasis</subject><subject>Psoriasis - blood</subject><subject>Superoxide Dismutase - blood</subject><subject>Uric Acid - blood</subject><subject>Young Adult</subject><issn>0263-6484</issn><issn>1099-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E9LwzAYx_EgiptT8BVIwYuXzCfNk9gc53AqDLzoOaRtghldW5uUuXdv5_wDgqfn8uHLw4-QcwZTBpBeF7mbcmDsgIwZKEUhQzwkY0glpxIzHJGTEFYAoCSHYzJKMVNCKjkmdFZH37z70tQxCdHEPiS-TloTva1jSDY-viZtaDpvgg-n5MiZKtizrzshL4u75_kDXT7dP85nS1pwVIwiUyIX4IALLDMD3EDmSkgdL5EXmcpTg85ad-PQKcudtMIag6isygqZIp-Qq3237Zq33oao1z4UtqpMbZs-aCZ4qlBJqQZ6-Yeumr6rh-8GxZCDFAJ-g0XXhNBZp9vOr0231Qz0bkI9TKh3Ew704ivY52tb_sDvzQZA92DjK7v9N6Tnt4vP4AfZF3hT</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Houshang, Nemati</creator><creator>Reza, Khodarahmi</creator><creator>Masoud, Sadeghi</creator><creator>Ali, Ebrahimi</creator><creator>Mansour, Rezaei</creator><creator>Vaisi‐Raygani, Asad</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Antioxidant status in patients with psoriasis</title><author>Houshang, Nemati ; Reza, Khodarahmi ; Masoud, Sadeghi ; Ali, Ebrahimi ; Mansour, Rezaei ; Vaisi‐Raygani, Asad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3491-4195b50f0354d8a03a08fd02f3d43c89b2a4feef7f4f9e3f6e5eaa449e98c6243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>antioxidant</topic><topic>Antioxidants - metabolism</topic><topic>Apolipoprotein A-I - blood</topic><topic>apolipoproteins</topic><topic>Apolipoproteins B - blood</topic><topic>Aryldialkylphosphatase - blood</topic><topic>Bilirubin - blood</topic><topic>Case-Control Studies</topic><topic>Catalase - blood</topic><topic>Female</topic><topic>Humans</topic><topic>lipids</topic><topic>Male</topic><topic>Middle Aged</topic><topic>oxidant</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>psoriasis</topic><topic>Psoriasis - blood</topic><topic>Superoxide Dismutase - blood</topic><topic>Uric Acid - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Houshang, Nemati</creatorcontrib><creatorcontrib>Reza, Khodarahmi</creatorcontrib><creatorcontrib>Masoud, Sadeghi</creatorcontrib><creatorcontrib>Ali, Ebrahimi</creatorcontrib><creatorcontrib>Mansour, Rezaei</creatorcontrib><creatorcontrib>Vaisi‐Raygani, Asad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell biochemistry and function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Houshang, Nemati</au><au>Reza, Khodarahmi</au><au>Masoud, Sadeghi</au><au>Ali, Ebrahimi</au><au>Mansour, Rezaei</au><au>Vaisi‐Raygani, Asad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant status in patients with psoriasis</atitle><jtitle>Cell biochemistry and function</jtitle><addtitle>Cell Biochem Funct</addtitle><date>2014-04</date><risdate>2014</risdate><volume>32</volume><issue>3</issue><spage>268</spage><epage>273</epage><pages>268-273</pages><issn>0263-6484</issn><eissn>1099-0844</eissn><abstract>Psoriasis is a chronic inflammatory skin disease with an unknown aetiology that has been associated with abnormal plasma lipid metabolism and oxidative stress. There are controversial results in the previous studies investigating oxidant/antioxidant systems in psoriasis.
The aim of this work was to evaluate the plasma levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total bilirubin (T. Bili), direct bilirubin (D. Bili), uric acid (UA), apolipoproteins (ApoA1 and ApoB), Lp(a) and activities of paraxonase 1 (PON1) in 100 patients with psoriasis and 100 controls, and to look for a correlation between these parameters in psoriasis.
PON1, bilirubin and UA were measured spectrophotometrically, MDA by the high‐performance liquid chromatography method, apolipoproteins and Lp(a) by immunoprecipitation assays, and lipid and other biochemical parameters were determined by routine laboratory methods.
In patients with psoriasis, there was a significant decrease in PON1, SOD and CAT activities (P < 0.05) and an increase in MDA levels (P < 0.01). Also, the levels of bilirubin (total and direct) and UA were decreased in patients with psoriasis but were not significant (P > 0.05).
These results suggest that psoriasis was in a state of oxidative stress and that the protective effects of high‐density lipoprotein against atherosclerosis may be dependent on PON1 activity. Moreover, there is a negative correlation between antioxidant with Lp(a), apoB and MDA levels, suggesting that subjects with higher levels of Lp(a) and apoB and lower levels of antioxidant are more exposed to oxidative damage. These findings may explain in part the reported increase in cardiovascular mortality in psoriasis. Copyright © 2013 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24895696</pmid><doi>10.1002/cbf.3011</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0263-6484 |
| ispartof | Cell biochemistry and function, 2014-04, Vol.32 (3), p.268-273 |
| issn | 0263-6484 1099-0844 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1532949669 |
| source | MEDLINE; Wiley Journals |
| subjects | Adult antioxidant Antioxidants - metabolism Apolipoprotein A-I - blood apolipoproteins Apolipoproteins B - blood Aryldialkylphosphatase - blood Bilirubin - blood Case-Control Studies Catalase - blood Female Humans lipids Male Middle Aged oxidant Oxidation-Reduction Oxidative Stress psoriasis Psoriasis - blood Superoxide Dismutase - blood Uric Acid - blood Young Adult |
| title | Antioxidant status in patients with psoriasis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T02%3A52%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antioxidant%20status%20in%20patients%20with%20psoriasis&rft.jtitle=Cell%20biochemistry%20and%20function&rft.au=Houshang,%20Nemati&rft.date=2014-04&rft.volume=32&rft.issue=3&rft.spage=268&rft.epage=273&rft.pages=268-273&rft.issn=0263-6484&rft.eissn=1099-0844&rft_id=info:doi/10.1002/cbf.3011&rft_dat=%3Cproquest_cross%3E1532949669%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1514306550&rft_id=info:pmid/24895696&rfr_iscdi=true |