The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review
Salvia miltiorrhiza Bunge (Danshen in Chinese) is a classical Huoxue Huayu (a traditional Chinese medical term means promoting blood circulation and removing blood stasis) herb with 1000 years of clinical application. It mainly contains two groups of ingredients: the hydrophilic phenolic acids and t...
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| Veröffentlicht in: | Medicinal research reviews 2014-07, Vol.34 (4), p.768-794 |
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| creator | Chen, Xiuping Guo, Jiajie Bao, Jiaolin Lu, Jinjian Wang, Yitao |
| description | Salvia miltiorrhiza Bunge (Danshen in Chinese) is a classical Huoxue Huayu (a traditional Chinese medical term means promoting blood circulation and removing blood stasis) herb with 1000 years of clinical application. It mainly contains two groups of ingredients: the hydrophilic phenolic acids and the lipophilic tanshinones. Both groups have demonstrated multiple bioactivities, such as antioxidative stress, antiplatelet aggregation, anti‐inflammation, among others. Recent data have demonstrated that its lipophilic compounds, especially the tanshinones, show potent anticancer activities both in vitro and in vivo. The anticancer effects of the hydrophilic phenolic acids have also been reported. Furthermore, tanshinones provide structural skeletons for chemical modifications, allowing for a series of derivatives of interests. This review provides a systematic summary of the anticancer profile and the underlying mechanisms of the bioactive compounds isolated from Danshen with special emphasis on tanshinones, aiming to bring new insights for further research and development of this ancient herb. |
| doi_str_mv | 10.1002/med.21304 |
| format | Article |
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It mainly contains two groups of ingredients: the hydrophilic phenolic acids and the lipophilic tanshinones. Both groups have demonstrated multiple bioactivities, such as antioxidative stress, antiplatelet aggregation, anti‐inflammation, among others. Recent data have demonstrated that its lipophilic compounds, especially the tanshinones, show potent anticancer activities both in vitro and in vivo. The anticancer effects of the hydrophilic phenolic acids have also been reported. Furthermore, tanshinones provide structural skeletons for chemical modifications, allowing for a series of derivatives of interests. This review provides a systematic summary of the anticancer profile and the underlying mechanisms of the bioactive compounds isolated from Danshen with special emphasis on tanshinones, aiming to bring new insights for further research and development of this ancient herb.</description><identifier>ISSN: 0198-6325</identifier><identifier>EISSN: 1098-1128</identifier><identifier>DOI: 10.1002/med.21304</identifier><identifier>PMID: 24123144</identifier><identifier>CODEN: MRREDD</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Cancer ; derivatives ; Humans ; Hydrophobic and Hydrophilic Interactions ; phenolic acids ; Salvia miltiorrhiza - chemistry ; Salvia miltiorrhiza Bunge ; tanshinones</subject><ispartof>Medicinal research reviews, 2014-07, Vol.34 (4), p.768-794</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><rights>Copyright © 2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4574-2cdd4bf400c692f746775b0a619cdd6170e924a42e4f89fa4faa842049339e443</citedby><cites>FETCH-LOGICAL-c4574-2cdd4bf400c692f746775b0a619cdd6170e924a42e4f89fa4faa842049339e443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmed.21304$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmed.21304$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24123144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Xiuping</creatorcontrib><creatorcontrib>Guo, Jiajie</creatorcontrib><creatorcontrib>Bao, Jiaolin</creatorcontrib><creatorcontrib>Lu, Jinjian</creatorcontrib><creatorcontrib>Wang, Yitao</creatorcontrib><title>The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review</title><title>Medicinal research reviews</title><addtitle>Med. Res. Rev</addtitle><description>Salvia miltiorrhiza Bunge (Danshen in Chinese) is a classical Huoxue Huayu (a traditional Chinese medical term means promoting blood circulation and removing blood stasis) herb with 1000 years of clinical application. It mainly contains two groups of ingredients: the hydrophilic phenolic acids and the lipophilic tanshinones. Both groups have demonstrated multiple bioactivities, such as antioxidative stress, antiplatelet aggregation, anti‐inflammation, among others. Recent data have demonstrated that its lipophilic compounds, especially the tanshinones, show potent anticancer activities both in vitro and in vivo. The anticancer effects of the hydrophilic phenolic acids have also been reported. Furthermore, tanshinones provide structural skeletons for chemical modifications, allowing for a series of derivatives of interests. This review provides a systematic summary of the anticancer profile and the underlying mechanisms of the bioactive compounds isolated from Danshen with special emphasis on tanshinones, aiming to bring new insights for further research and development of this ancient herb.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Cancer</subject><subject>derivatives</subject><subject>Humans</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>phenolic acids</subject><subject>Salvia miltiorrhiza - chemistry</subject><subject>Salvia miltiorrhiza Bunge</subject><subject>tanshinones</subject><issn>0198-6325</issn><issn>1098-1128</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1vEzEQQC0EomnhwB9Alri0h2099uyHuYV-BFBaEE0F6sVyNrPEZbOb2rttw6_HIQ0HpJ5s2W-eRo-xNyAOQQh5tKDZoQQl8BkbgNBFAiCL52wgIN4zJdMdthvCjRAAKaiXbEciSAWIA3Y1mRMfNp0rbVOS5199uyTfOQq8rfilre-c5eeu7lzr_dz9tvxD3_wkvn9imzCn5uA9H_LLVehoYaOEf6M7R_ev2IvK1oFeP5577OrsdHL8MRl_GX06Ho6TEtMcE1nOZjitUIgy07LKMcvzdCpsBjr-ZJAL0hItSsKq0JXFytoCpUCtlCZEtcf2N96lb297Cp1ZuFBSXduG2j4YSJXUWKS5iOi7_9CbtvdN3G5NQaFjsixSBxuq9G0Iniqz9G5h_cqAMOvWJrY2f1tH9u2jsZ-uX7fkNm4EjjbAvatp9bTJnJ-ebJXJZsLFoA__Jqz_ZbJc5an5fjEy158nP9Lr8cgo9Qc1FJT0</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Chen, Xiuping</creator><creator>Guo, Jiajie</creator><creator>Bao, Jiaolin</creator><creator>Lu, Jinjian</creator><creator>Wang, Yitao</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201407</creationdate><title>The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review</title><author>Chen, Xiuping ; Guo, Jiajie ; Bao, Jiaolin ; Lu, Jinjian ; Wang, Yitao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4574-2cdd4bf400c692f746775b0a619cdd6170e924a42e4f89fa4faa842049339e443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Cancer</topic><topic>derivatives</topic><topic>Humans</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>phenolic acids</topic><topic>Salvia miltiorrhiza - chemistry</topic><topic>Salvia miltiorrhiza Bunge</topic><topic>tanshinones</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xiuping</creatorcontrib><creatorcontrib>Guo, Jiajie</creatorcontrib><creatorcontrib>Bao, Jiaolin</creatorcontrib><creatorcontrib>Lu, Jinjian</creatorcontrib><creatorcontrib>Wang, Yitao</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Medicinal research reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xiuping</au><au>Guo, Jiajie</au><au>Bao, Jiaolin</au><au>Lu, Jinjian</au><au>Wang, Yitao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review</atitle><jtitle>Medicinal research reviews</jtitle><addtitle>Med. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cancer derivatives Humans Hydrophobic and Hydrophilic Interactions phenolic acids Salvia miltiorrhiza - chemistry Salvia miltiorrhiza Bunge tanshinones |
| title | The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review |
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