Evidence for the metabolism of tumor promoter organic hydroperoxides into free radicals by human carcinoma skin keratinocytes: an ESR-spin trapping study

Humans are exposed to various peroxy and hydroperoxy compounds which are in use in the cosmetic, pharmaceutical and polymer industries and which are also generated as a result of the peroxidative metabolic conversion of certain lipids. This study was designed to determine whether the organic hydrope...

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Veröffentlicht in:	Carcinogenesis (New York) 1989-08, Vol.10 (8), p.1499-1503
Hauptverfasser:	Athar, Mohammad, Mukhtar, Hasan, Bickers, David R., Khan, Islam U., Kalyanaraman, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzene Derivatives - metabolism Benzenesulfonates Benzoates - metabolism Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinoma, Squamous Cell - metabolism Cell Line Chemical agents Electron Spin Resonance Spectroscopy - methods Epidermal Cells Epidermis - metabolism Free Radicals Humans Keratins - metabolism Kinetics Medical sciences Nitroso Compounds Peroxides - metabolism Skin Neoplasms - metabolism Spin Labels tert-Butylhydroperoxide Tumors
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