Sexual dimorphism in autonomic changes and in the renin–angiotensin system in the hearts of mice subjected to thyroid hormone‐induced cardiac hypertrophy
New Findings What is the central question of this study? Based on the relevance of the renin–angiotensin system and the controversy regarding the role of the sympathetic nervous system in thyroid hormone‐related cardiac hypertrophy, the present study sought to establish whether there is a gender dif...
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| Veröffentlicht in: | Experimental physiology 2014-06, Vol.99 (6), p.868-880 |
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| creator | Bezerra da Silveira, Anderson Luiz Souza Miranda, Manuela França Mecawi, André Souza Melo, Roberto Laureano Marassi, Michelle Porto Matos da Silva, Alba Cenélia Antunes‐Rodrigues, José Olivares, Emerson Lopes |
| description | New Findings
What is the central question of this study?
Based on the relevance of the renin–angiotensin system and the controversy regarding the role of the sympathetic nervous system in thyroid hormone‐related cardiac hypertrophy, the present study sought to establish whether there is a gender difference in activation of these systems and the degree of cardiac hypertrophy in mice.
What is the main finding and its importance?
Triiodothyronine increased sympathetic modulation and induced higher levels of cardiac angiotensin II in male than in female mice. This could explain the greater degree of cardiac hypertrophy induced by thyroid hormone found in the male mice.
Based on the relevance of the renin–angiotensin system and the ongoing controversy regarding the role of the sympathetic nervous system in thyroid hormone‐induced cardiac hypertrophy, the aim of the present study was to establish whether the putative difference in the degree of cardiac hypertrophy exhibited by males and females might be related to differences in the sympathetic–vagal balance and/or in the cardiac renin–angiotensin system in mice of different genders. Male and female mice (n = 117) were given 0.1 mg kg−1 of triiodothyronine or normal saline each day for 10 days consecutively. At the end of that period, study of the heart rate variability, spectral analysis and histopathological examination were performed to assess the sympathetic–vagal balance and the diameter of cardiomyocytes. The cardiac levels of angiotensin I and II were also measured. Treatment with triiodothyronine induced a greater degree of cardiac hypertrophy in male (∼73%) than in female mice (∼42%). This difference was attributed to greater modulation of the sympathetic nervous system and higher levels of angiotensin I and II in male than in female mice. Our data indicate that thyroid hormone‐induced cardiac hypertrophy was more intense in male mice due to the synergic effect of the sympathetic nervous system and the cardiac renin–angiotensin system. |
| doi_str_mv | 10.1113/expphysiol.2013.076976 |
| format | Article |
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What is the central question of this study?
Based on the relevance of the renin–angiotensin system and the controversy regarding the role of the sympathetic nervous system in thyroid hormone‐related cardiac hypertrophy, the present study sought to establish whether there is a gender difference in activation of these systems and the degree of cardiac hypertrophy in mice.
What is the main finding and its importance?
Triiodothyronine increased sympathetic modulation and induced higher levels of cardiac angiotensin II in male than in female mice. This could explain the greater degree of cardiac hypertrophy induced by thyroid hormone found in the male mice.
Based on the relevance of the renin–angiotensin system and the ongoing controversy regarding the role of the sympathetic nervous system in thyroid hormone‐induced cardiac hypertrophy, the aim of the present study was to establish whether the putative difference in the degree of cardiac hypertrophy exhibited by males and females might be related to differences in the sympathetic–vagal balance and/or in the cardiac renin–angiotensin system in mice of different genders. Male and female mice (n = 117) were given 0.1 mg kg−1 of triiodothyronine or normal saline each day for 10 days consecutively. At the end of that period, study of the heart rate variability, spectral analysis and histopathological examination were performed to assess the sympathetic–vagal balance and the diameter of cardiomyocytes. The cardiac levels of angiotensin I and II were also measured. Treatment with triiodothyronine induced a greater degree of cardiac hypertrophy in male (∼73%) than in female mice (∼42%). This difference was attributed to greater modulation of the sympathetic nervous system and higher levels of angiotensin I and II in male than in female mice. Our data indicate that thyroid hormone‐induced cardiac hypertrophy was more intense in male mice due to the synergic effect of the sympathetic nervous system and the cardiac renin–angiotensin system.</description><identifier>ISSN: 0958-0670</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/expphysiol.2013.076976</identifier><identifier>PMID: 24659612</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Animals ; Autonomic Nervous System - drug effects ; Autonomic Nervous System - physiology ; Cardiomegaly - blood ; Cardiomegaly - chemically induced ; Female ; Male ; Mice ; Random Allocation ; Renin-Angiotensin System - drug effects ; Renin-Angiotensin System - physiology ; Sex Characteristics ; Thyroid Hormones - blood ; Thyroid Hormones - toxicity</subject><ispartof>Experimental physiology, 2014-06, Vol.99 (6), p.868-880</ispartof><rights>2014 The Authors. Experimental Physiology © 2014 The Physiological Society</rights><rights>2014 The Authors. Experimental Physiology © 2014 The Physiological Society.</rights><rights>2014 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4393-ad8158f8fb6398f63bc863f694606198b1433394ae9a6124f923628508189c033</citedby><cites>FETCH-LOGICAL-c4393-ad8158f8fb6398f63bc863f694606198b1433394ae9a6124f923628508189c033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2Fexpphysiol.2013.076976$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2Fexpphysiol.2013.076976$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24659612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bezerra da Silveira, Anderson Luiz</creatorcontrib><creatorcontrib>Souza Miranda, Manuela França</creatorcontrib><creatorcontrib>Mecawi, André Souza</creatorcontrib><creatorcontrib>Melo, Roberto Laureano</creatorcontrib><creatorcontrib>Marassi, Michelle Porto</creatorcontrib><creatorcontrib>Matos da Silva, Alba Cenélia</creatorcontrib><creatorcontrib>Antunes‐Rodrigues, José</creatorcontrib><creatorcontrib>Olivares, Emerson Lopes</creatorcontrib><title>Sexual dimorphism in autonomic changes and in the renin–angiotensin system in the hearts of mice subjected to thyroid hormone‐induced cardiac hypertrophy</title><title>Experimental physiology</title><addtitle>Exp Physiol</addtitle><description>New Findings
What is the central question of this study?
Based on the relevance of the renin–angiotensin system and the controversy regarding the role of the sympathetic nervous system in thyroid hormone‐related cardiac hypertrophy, the present study sought to establish whether there is a gender difference in activation of these systems and the degree of cardiac hypertrophy in mice.
What is the main finding and its importance?
Triiodothyronine increased sympathetic modulation and induced higher levels of cardiac angiotensin II in male than in female mice. This could explain the greater degree of cardiac hypertrophy induced by thyroid hormone found in the male mice.
Based on the relevance of the renin–angiotensin system and the ongoing controversy regarding the role of the sympathetic nervous system in thyroid hormone‐induced cardiac hypertrophy, the aim of the present study was to establish whether the putative difference in the degree of cardiac hypertrophy exhibited by males and females might be related to differences in the sympathetic–vagal balance and/or in the cardiac renin–angiotensin system in mice of different genders. Male and female mice (n = 117) were given 0.1 mg kg−1 of triiodothyronine or normal saline each day for 10 days consecutively. At the end of that period, study of the heart rate variability, spectral analysis and histopathological examination were performed to assess the sympathetic–vagal balance and the diameter of cardiomyocytes. The cardiac levels of angiotensin I and II were also measured. Treatment with triiodothyronine induced a greater degree of cardiac hypertrophy in male (∼73%) than in female mice (∼42%). This difference was attributed to greater modulation of the sympathetic nervous system and higher levels of angiotensin I and II in male than in female mice. Our data indicate that thyroid hormone‐induced cardiac hypertrophy was more intense in male mice due to the synergic effect of the sympathetic nervous system and the cardiac renin–angiotensin system.</description><subject>Animals</subject><subject>Autonomic Nervous System - drug effects</subject><subject>Autonomic Nervous System - physiology</subject><subject>Cardiomegaly - blood</subject><subject>Cardiomegaly - chemically induced</subject><subject>Female</subject><subject>Male</subject><subject>Mice</subject><subject>Random Allocation</subject><subject>Renin-Angiotensin System - drug effects</subject><subject>Renin-Angiotensin System - physiology</subject><subject>Sex Characteristics</subject><subject>Thyroid Hormones - blood</subject><subject>Thyroid Hormones - toxicity</subject><issn>0958-0670</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFqFTEUhoMo9lp9hRJw42auySSTm-BKSrVCQUEFdyGTOePkMpOMSQY7uz6C4NqX65OYy20VXLkK5P_OT04-hM4o2VJK2Uu4nudhTS6M25pQtiU7oXbiAdpQLlTFefPlIdoQ1ciKiB05QU9S2pMCEskfo5Oai0YJWm_Qr49wvZgRd24KcR5cmrDz2Cw5-DA5i-1g_FdI2PjuEOQBcATv_O3NzxK4kMGncp_WlGG6JwYwMSccelwqAKel3YPN0OEcSr7G4Do8hDgFD7c3P5zvFltCa2LnjMXDOkPMMZT9nqJHvRkTPLs7T9HnNxefzi-rq_dv352_vqosZ4pVppO0kb3sW8GU7AVrrRSsF4oLIqiSLeWMMcUNKFO25r2qmahlQySVyhLGTtGLY-8cw7cFUtaTSxbG0XgIS9K0YTWXvN7xgj7_B92HJfryugNFOKGcikKJI2VjSClCr-foJhNXTYk-CNR_BeqDQH0UWAbP7uqXdoLuz9i9sQK8OgLf3Qjrf9bqiw-XlJdP-A107LD_</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Bezerra da Silveira, Anderson Luiz</creator><creator>Souza Miranda, Manuela França</creator><creator>Mecawi, André Souza</creator><creator>Melo, Roberto Laureano</creator><creator>Marassi, Michelle Porto</creator><creator>Matos da Silva, Alba Cenélia</creator><creator>Antunes‐Rodrigues, José</creator><creator>Olivares, Emerson Lopes</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Sexual dimorphism in autonomic changes and in the renin–angiotensin system in the hearts of mice subjected to thyroid hormone‐induced cardiac hypertrophy</title><author>Bezerra da Silveira, Anderson Luiz ; Souza Miranda, Manuela França ; Mecawi, André Souza ; Melo, Roberto Laureano ; Marassi, Michelle Porto ; Matos da Silva, Alba Cenélia ; Antunes‐Rodrigues, José ; Olivares, Emerson Lopes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4393-ad8158f8fb6398f63bc863f694606198b1433394ae9a6124f923628508189c033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Autonomic Nervous System - drug effects</topic><topic>Autonomic Nervous System - physiology</topic><topic>Cardiomegaly - blood</topic><topic>Cardiomegaly - chemically induced</topic><topic>Female</topic><topic>Male</topic><topic>Mice</topic><topic>Random Allocation</topic><topic>Renin-Angiotensin System - drug effects</topic><topic>Renin-Angiotensin System - physiology</topic><topic>Sex Characteristics</topic><topic>Thyroid Hormones - blood</topic><topic>Thyroid Hormones - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bezerra da Silveira, Anderson Luiz</creatorcontrib><creatorcontrib>Souza Miranda, Manuela França</creatorcontrib><creatorcontrib>Mecawi, André Souza</creatorcontrib><creatorcontrib>Melo, Roberto Laureano</creatorcontrib><creatorcontrib>Marassi, Michelle Porto</creatorcontrib><creatorcontrib>Matos da Silva, Alba Cenélia</creatorcontrib><creatorcontrib>Antunes‐Rodrigues, José</creatorcontrib><creatorcontrib>Olivares, Emerson Lopes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bezerra da Silveira, Anderson Luiz</au><au>Souza Miranda, Manuela França</au><au>Mecawi, André Souza</au><au>Melo, Roberto Laureano</au><au>Marassi, Michelle Porto</au><au>Matos da Silva, Alba Cenélia</au><au>Antunes‐Rodrigues, José</au><au>Olivares, Emerson Lopes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexual dimorphism in autonomic changes and in the renin–angiotensin system in the hearts of mice subjected to thyroid hormone‐induced cardiac hypertrophy</atitle><jtitle>Experimental physiology</jtitle><addtitle>Exp Physiol</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>99</volume><issue>6</issue><spage>868</spage><epage>880</epage><pages>868-880</pages><issn>0958-0670</issn><eissn>1469-445X</eissn><abstract>New Findings
What is the central question of this study?
Based on the relevance of the renin–angiotensin system and the controversy regarding the role of the sympathetic nervous system in thyroid hormone‐related cardiac hypertrophy, the present study sought to establish whether there is a gender difference in activation of these systems and the degree of cardiac hypertrophy in mice.
What is the main finding and its importance?
Triiodothyronine increased sympathetic modulation and induced higher levels of cardiac angiotensin II in male than in female mice. This could explain the greater degree of cardiac hypertrophy induced by thyroid hormone found in the male mice.
Based on the relevance of the renin–angiotensin system and the ongoing controversy regarding the role of the sympathetic nervous system in thyroid hormone‐induced cardiac hypertrophy, the aim of the present study was to establish whether the putative difference in the degree of cardiac hypertrophy exhibited by males and females might be related to differences in the sympathetic–vagal balance and/or in the cardiac renin–angiotensin system in mice of different genders. Male and female mice (n = 117) were given 0.1 mg kg−1 of triiodothyronine or normal saline each day for 10 days consecutively. At the end of that period, study of the heart rate variability, spectral analysis and histopathological examination were performed to assess the sympathetic–vagal balance and the diameter of cardiomyocytes. The cardiac levels of angiotensin I and II were also measured. Treatment with triiodothyronine induced a greater degree of cardiac hypertrophy in male (∼73%) than in female mice (∼42%). This difference was attributed to greater modulation of the sympathetic nervous system and higher levels of angiotensin I and II in male than in female mice. Our data indicate that thyroid hormone‐induced cardiac hypertrophy was more intense in male mice due to the synergic effect of the sympathetic nervous system and the cardiac renin–angiotensin system.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>24659612</pmid><doi>10.1113/expphysiol.2013.076976</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Autonomic Nervous System - drug effects Autonomic Nervous System - physiology Cardiomegaly - blood Cardiomegaly - chemically induced Female Male Mice Random Allocation Renin-Angiotensin System - drug effects Renin-Angiotensin System - physiology Sex Characteristics Thyroid Hormones - blood Thyroid Hormones - toxicity |
| title | Sexual dimorphism in autonomic changes and in the renin–angiotensin system in the hearts of mice subjected to thyroid hormone‐induced cardiac hypertrophy |
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