Functional role and mechanisms of sialyllactose and other sialylated milk oligosaccharides
Human milk is a rich source of oligosaccharides. Acidic oligosaccharides, such as sialyllactose (SL), contain sialic acid (SA) residues. In human milk, approximately 73% of SA is bound to oligosaccharides, whereas only 3% is present in free form. Oligosaccharides are highly resistant to hydrolysis i...
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| Veröffentlicht in: | Nutrition reviews 2014-06, Vol.72 (6), p.377-389 |
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| creator | Bruggencate, Sandra JM Bovee‐Oudenhoven, Ingeborg MJ Feitsma, Anouk L Hoffen, Els Schoterman, Margriet HC |
| description | Human milk is a rich source of oligosaccharides. Acidic oligosaccharides, such as sialyllactose (SL), contain sialic acid (SA) residues. In human milk, approximately 73% of SA is bound to oligosaccharides, whereas only 3% is present in free form. Oligosaccharides are highly resistant to hydrolysis in the gastrointestinal tract. Only a small portion of the available oligosaccharides in breast milk is absorbed in the neonatal small intestine. SL and sialylated oligosaccharides are thought to have significant health benefits for the neonate, because of their roles in supporting resistance to pathogens, gut maturation, immune function, and cognitive development. The need for SA to allow proper development during the neonatal period is thought to exceed the endogenous synthesis. Therefore, these structures are important nutrients for the neonate. Based on the potential benefits, SL and sialylated oligosaccharides may be interesting components for application in infant nutrition. Once the hurdle of limited availability of these oligosaccharides has been overcome, their functionality can be explored in more detail, and supplementation of infant formula may become feasible. |
| doi_str_mv | 10.1111/nure.12106 |
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Acidic oligosaccharides, such as sialyllactose (SL), contain sialic acid (SA) residues. In human milk, approximately 73% of SA is bound to oligosaccharides, whereas only 3% is present in free form. Oligosaccharides are highly resistant to hydrolysis in the gastrointestinal tract. Only a small portion of the available oligosaccharides in breast milk is absorbed in the neonatal small intestine. SL and sialylated oligosaccharides are thought to have significant health benefits for the neonate, because of their roles in supporting resistance to pathogens, gut maturation, immune function, and cognitive development. The need for SA to allow proper development during the neonatal period is thought to exceed the endogenous synthesis. Therefore, these structures are important nutrients for the neonate. Based on the potential benefits, SL and sialylated oligosaccharides may be interesting components for application in infant nutrition. Once the hurdle of limited availability of these oligosaccharides has been overcome, their functionality can be explored in more detail, and supplementation of infant formula may become feasible.</description><identifier>ISSN: 0029-6643</identifier><identifier>EISSN: 1753-4887</identifier><identifier>DOI: 10.1111/nure.12106</identifier><identifier>PMID: 24828428</identifier><identifier>CODEN: NUREA8</identifier><language>eng</language><publisher>Hoboken, NJ: International Life Sciences Institute</publisher><subject>Animals ; Biological and medical sciences ; Breast Feeding ; breast milk ; cognitive development ; Diet ; Dietary Supplements ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal Tract - metabolism ; health effects ; human milk oligosaccharides ; Humans ; hydrolysis ; Infant ; Infant Formula - chemistry ; infant formulas ; infant nutrition ; Infant Nutritional Physiological Phenomena ; Lactose - analogs & derivatives ; Lactose - metabolism ; Milk ; Milk, Human - chemistry ; neonates ; nutrients ; Nutritional Requirements ; oligosaccharides ; Oligosaccharides - metabolism ; Pathogens ; sialic acid ; Sialic Acids - metabolism ; sialylated oligosaccharides ; sialyllactose ; Small intestine ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Nutrition reviews, 2014-06, Vol.72 (6), p.377-389</ispartof><rights>2014 International Life Sciences Institute</rights><rights>2015 INIST-CNRS</rights><rights>2014 International Life Sciences Institute.</rights><rights>Copyright International Life Sciences Institute Jun 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5546-bc7afa3af5361f71fc77f94ed23155a92539583af2f2509b5bbbc29c92c0c9773</citedby><cites>FETCH-LOGICAL-c5546-bc7afa3af5361f71fc77f94ed23155a92539583af2f2509b5bbbc29c92c0c9773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnure.12106$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnure.12106$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28575665$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24828428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bruggencate, Sandra JM</creatorcontrib><creatorcontrib>Bovee‐Oudenhoven, Ingeborg MJ</creatorcontrib><creatorcontrib>Feitsma, Anouk L</creatorcontrib><creatorcontrib>Hoffen, Els</creatorcontrib><creatorcontrib>Schoterman, Margriet HC</creatorcontrib><title>Functional role and mechanisms of sialyllactose and other sialylated milk oligosaccharides</title><title>Nutrition reviews</title><addtitle>Nutr Rev</addtitle><description>Human milk is a rich source of oligosaccharides. Acidic oligosaccharides, such as sialyllactose (SL), contain sialic acid (SA) residues. In human milk, approximately 73% of SA is bound to oligosaccharides, whereas only 3% is present in free form. Oligosaccharides are highly resistant to hydrolysis in the gastrointestinal tract. Only a small portion of the available oligosaccharides in breast milk is absorbed in the neonatal small intestine. SL and sialylated oligosaccharides are thought to have significant health benefits for the neonate, because of their roles in supporting resistance to pathogens, gut maturation, immune function, and cognitive development. The need for SA to allow proper development during the neonatal period is thought to exceed the endogenous synthesis. Therefore, these structures are important nutrients for the neonate. Based on the potential benefits, SL and sialylated oligosaccharides may be interesting components for application in infant nutrition. Once the hurdle of limited availability of these oligosaccharides has been overcome, their functionality can be explored in more detail, and supplementation of infant formula may become feasible.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Breast Feeding</subject><subject>breast milk</subject><subject>cognitive development</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>health effects</subject><subject>human milk oligosaccharides</subject><subject>Humans</subject><subject>hydrolysis</subject><subject>Infant</subject><subject>Infant Formula - chemistry</subject><subject>infant formulas</subject><subject>infant nutrition</subject><subject>Infant Nutritional Physiological Phenomena</subject><subject>Lactose - analogs & derivatives</subject><subject>Lactose - metabolism</subject><subject>Milk</subject><subject>Milk, Human - chemistry</subject><subject>neonates</subject><subject>nutrients</subject><subject>Nutritional Requirements</subject><subject>oligosaccharides</subject><subject>Oligosaccharides - metabolism</subject><subject>Pathogens</subject><subject>sialic acid</subject><subject>Sialic Acids - metabolism</subject><subject>sialylated oligosaccharides</subject><subject>sialyllactose</subject><subject>Small intestine</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0029-6643</issn><issn>1753-4887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFrFTEQhYMo9lp98QfogggibM0km83mUUprhVJBvS--hNncpE3NbtpkF7n_3tzubQUfmpdA5jtnZk4IeQ30CMr5NM7JHgED2j4hK5CC103XyadkRSlTdds2_IC8yPmaUgpM8efkgDUd6xrWrciv03k0k48jhirFYCscN9VgzRWOPg-5iq7KHsM2BDRTzEs9Tlc27d9xskXgw-8qBn8ZM5qiTX5j80vyzGHI9tX-PiTr05Ofx2f1-bcvX48_n9dGiKateyPRIUcneAtOgjNSOtXYDeMgBComuBJdqTPHBFW96PveMGUUM9QoKfkh-bD43qR4O9s86cFnY8vEo41z1iB42RdUSwv67j_0Os6p7H5HyTIAdDvDjwtlUsw5Wadvkh8wbTVQvUtc7xLXd4kX-M3ecu4Hu3lA7yMuwPs9gNlgcAlH4_M_rhNStK0oHCzcHx_s9pGW-mL9_eS--dtF4zBqvEzFd_2DUWjKTwsQCvhfq_Ohyg</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Bruggencate, Sandra JM</creator><creator>Bovee‐Oudenhoven, Ingeborg MJ</creator><creator>Feitsma, Anouk L</creator><creator>Hoffen, Els</creator><creator>Schoterman, Margriet HC</creator><general>International Life Sciences Institute</general><general>Wiley</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201406</creationdate><title>Functional role and mechanisms of sialyllactose and other sialylated milk oligosaccharides</title><author>Bruggencate, Sandra JM ; Bovee‐Oudenhoven, Ingeborg MJ ; Feitsma, Anouk L ; Hoffen, Els ; Schoterman, Margriet HC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5546-bc7afa3af5361f71fc77f94ed23155a92539583af2f2509b5bbbc29c92c0c9773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Breast Feeding</topic><topic>breast milk</topic><topic>cognitive development</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>health effects</topic><topic>human milk oligosaccharides</topic><topic>Humans</topic><topic>hydrolysis</topic><topic>Infant</topic><topic>Infant Formula - chemistry</topic><topic>infant formulas</topic><topic>infant nutrition</topic><topic>Infant Nutritional Physiological Phenomena</topic><topic>Lactose - analogs & derivatives</topic><topic>Lactose - metabolism</topic><topic>Milk</topic><topic>Milk, Human - chemistry</topic><topic>neonates</topic><topic>nutrients</topic><topic>Nutritional Requirements</topic><topic>oligosaccharides</topic><topic>Oligosaccharides - metabolism</topic><topic>Pathogens</topic><topic>sialic acid</topic><topic>Sialic Acids - metabolism</topic><topic>sialylated oligosaccharides</topic><topic>sialyllactose</topic><topic>Small intestine</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bruggencate, Sandra JM</creatorcontrib><creatorcontrib>Bovee‐Oudenhoven, Ingeborg MJ</creatorcontrib><creatorcontrib>Feitsma, Anouk L</creatorcontrib><creatorcontrib>Hoffen, Els</creatorcontrib><creatorcontrib>Schoterman, Margriet HC</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bruggencate, Sandra JM</au><au>Bovee‐Oudenhoven, Ingeborg MJ</au><au>Feitsma, Anouk L</au><au>Hoffen, Els</au><au>Schoterman, Margriet HC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional role and mechanisms of sialyllactose and other sialylated milk oligosaccharides</atitle><jtitle>Nutrition reviews</jtitle><addtitle>Nutr Rev</addtitle><date>2014-06</date><risdate>2014</risdate><volume>72</volume><issue>6</issue><spage>377</spage><epage>389</epage><pages>377-389</pages><issn>0029-6643</issn><eissn>1753-4887</eissn><coden>NUREA8</coden><abstract>Human milk is a rich source of oligosaccharides. Acidic oligosaccharides, such as sialyllactose (SL), contain sialic acid (SA) residues. In human milk, approximately 73% of SA is bound to oligosaccharides, whereas only 3% is present in free form. Oligosaccharides are highly resistant to hydrolysis in the gastrointestinal tract. Only a small portion of the available oligosaccharides in breast milk is absorbed in the neonatal small intestine. SL and sialylated oligosaccharides are thought to have significant health benefits for the neonate, because of their roles in supporting resistance to pathogens, gut maturation, immune function, and cognitive development. The need for SA to allow proper development during the neonatal period is thought to exceed the endogenous synthesis. Therefore, these structures are important nutrients for the neonate. Based on the potential benefits, SL and sialylated oligosaccharides may be interesting components for application in infant nutrition. Once the hurdle of limited availability of these oligosaccharides has been overcome, their functionality can be explored in more detail, and supplementation of infant formula may become feasible.</abstract><cop>Hoboken, NJ</cop><pub>International Life Sciences Institute</pub><pmid>24828428</pmid><doi>10.1111/nure.12106</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences Breast Feeding breast milk cognitive development Diet Dietary Supplements Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - metabolism health effects human milk oligosaccharides Humans hydrolysis Infant Infant Formula - chemistry infant formulas infant nutrition Infant Nutritional Physiological Phenomena Lactose - analogs & derivatives Lactose - metabolism Milk Milk, Human - chemistry neonates nutrients Nutritional Requirements oligosaccharides Oligosaccharides - metabolism Pathogens sialic acid Sialic Acids - metabolism sialylated oligosaccharides sialyllactose Small intestine Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Functional role and mechanisms of sialyllactose and other sialylated milk oligosaccharides |
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