Rhythm and Mood: Relationships Between the Circadian Clock and Mood-Related Behavior
Mood disorders are multifactorial and heterogeneous diseases caused by the interplay of several genetic and environmental factors. In humans, mood disorders are often accompanied by abnormalities in the organization of the circadian system, which normally synchronizes activities and functions of cel...
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| Veröffentlicht in: | Behavioral neuroscience 2014-06, Vol.128 (3), p.326-343 |
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| creator | Schnell, Anna Albrecht, Urs Sandrelli, Federica |
| description | Mood disorders are multifactorial and heterogeneous diseases caused by the interplay of several genetic and environmental factors. In humans, mood disorders are often accompanied by abnormalities in the organization of the circadian system, which normally synchronizes activities and functions of cells and tissues. Studies on animal models suggest that the basic circadian clock mechanism, which runs in essentially all cells, is implicated in the modulation of biological phenomena regulating affective behaviors. In particular, recent findings highlight the importance of the circadian clock mechanisms in neurological pathways involved in mood, such as monoaminergic neurotransmission, hypothalamus-pituitary-adrenal axis regulation, suprachiasmatic nucleus and olfactory bulb activities, and neurogenesis. Defects at the level of both, the circadian clock mechanism and system, may contribute to the etiology of mood disorders. Modification of the circadian system using chronotherapy appears to be an effective treatment for mood disorders. Additionally, understanding the role of circadian clock mechanisms, which affect the regulation of different mood pathways, will open up the possibility for targeted pharmacological treatments. |
| doi_str_mv | 10.1037/a0035883 |
| format | Article |
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In humans, mood disorders are often accompanied by abnormalities in the organization of the circadian system, which normally synchronizes activities and functions of cells and tissues. Studies on animal models suggest that the basic circadian clock mechanism, which runs in essentially all cells, is implicated in the modulation of biological phenomena regulating affective behaviors. In particular, recent findings highlight the importance of the circadian clock mechanisms in neurological pathways involved in mood, such as monoaminergic neurotransmission, hypothalamus-pituitary-adrenal axis regulation, suprachiasmatic nucleus and olfactory bulb activities, and neurogenesis. Defects at the level of both, the circadian clock mechanism and system, may contribute to the etiology of mood disorders. Modification of the circadian system using chronotherapy appears to be an effective treatment for mood disorders. Additionally, understanding the role of circadian clock mechanisms, which affect the regulation of different mood pathways, will open up the possibility for targeted pharmacological treatments.</description><identifier>ISSN: 0735-7044</identifier><identifier>ISBN: 1433818418</identifier><identifier>ISBN: 9781433818417</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/a0035883</identifier><identifier>PMID: 24660658</identifier><language>eng</language><publisher>United States: American Psychological Association</publisher><subject>Affect ; Affective Disorders ; Animal ; Animal Circadian Rhythms ; Animal Models ; Animals ; Antidepressive Agents - therapeutic use ; Biogenic Monoamines - metabolism ; Chronobiology Disorders - complications ; Chronotherapy - methods ; Circadian Clocks - genetics ; Circadian Clocks - physiology ; Human ; Humans ; Hypothalamic Pituitary Adrenal Axis ; Hypothalamo-Hypophyseal System - physiopathology ; Models, Biological ; Mood Disorders - complications ; Mood Disorders - drug therapy ; Mood Disorders - genetics ; Mood Disorders - metabolism ; Mood Disorders - physiopathology ; Mood Disorders - therapy ; Neurogenesis ; Neurogenesis - physiology ; Neurotransmission ; Olfactory Bulb ; Olfactory Bulb - physiopathology ; Photoperiod ; Pituitary-Adrenal System - physiopathology ; Suprachiasmatic Nucleus ; Suprachiasmatic Nucleus - physiopathology ; Time ; Treatment</subject><ispartof>Behavioral neuroscience, 2014-06, Vol.128 (3), p.326-343</ispartof><rights>2014 American Psychological Association</rights><rights>PsycINFO Database Record (c) 2014 APA, all rights reserved.</rights><rights>2014, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a348t-88250c2f7aacbc22dc493a36820d2cd8ed3cac672c85672dca6502f1a97162b3</citedby><orcidid>0000-0002-5631-7467 ; 0000-0002-0663-8676</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24660658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Blumberg, Mark S</contributor><contributor>Nelson, Randy J</contributor><contributor>Weil, Zachary M</contributor><creatorcontrib>Schnell, Anna</creatorcontrib><creatorcontrib>Albrecht, Urs</creatorcontrib><creatorcontrib>Sandrelli, Federica</creatorcontrib><title>Rhythm and Mood: Relationships Between the Circadian Clock and Mood-Related Behavior</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Mood disorders are multifactorial and heterogeneous diseases caused by the interplay of several genetic and environmental factors. In humans, mood disorders are often accompanied by abnormalities in the organization of the circadian system, which normally synchronizes activities and functions of cells and tissues. Studies on animal models suggest that the basic circadian clock mechanism, which runs in essentially all cells, is implicated in the modulation of biological phenomena regulating affective behaviors. In particular, recent findings highlight the importance of the circadian clock mechanisms in neurological pathways involved in mood, such as monoaminergic neurotransmission, hypothalamus-pituitary-adrenal axis regulation, suprachiasmatic nucleus and olfactory bulb activities, and neurogenesis. Defects at the level of both, the circadian clock mechanism and system, may contribute to the etiology of mood disorders. Modification of the circadian system using chronotherapy appears to be an effective treatment for mood disorders. Additionally, understanding the role of circadian clock mechanisms, which affect the regulation of different mood pathways, will open up the possibility for targeted pharmacological treatments.</description><subject>Affect</subject><subject>Affective Disorders</subject><subject>Animal</subject><subject>Animal Circadian Rhythms</subject><subject>Animal Models</subject><subject>Animals</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biogenic Monoamines - metabolism</subject><subject>Chronobiology Disorders - complications</subject><subject>Chronotherapy - methods</subject><subject>Circadian Clocks - genetics</subject><subject>Circadian Clocks - physiology</subject><subject>Human</subject><subject>Humans</subject><subject>Hypothalamic Pituitary Adrenal Axis</subject><subject>Hypothalamo-Hypophyseal System - physiopathology</subject><subject>Models, Biological</subject><subject>Mood Disorders - complications</subject><subject>Mood Disorders - drug therapy</subject><subject>Mood Disorders - genetics</subject><subject>Mood Disorders - metabolism</subject><subject>Mood Disorders - physiopathology</subject><subject>Mood Disorders - therapy</subject><subject>Neurogenesis</subject><subject>Neurogenesis - physiology</subject><subject>Neurotransmission</subject><subject>Olfactory Bulb</subject><subject>Olfactory Bulb - physiopathology</subject><subject>Photoperiod</subject><subject>Pituitary-Adrenal System - physiopathology</subject><subject>Suprachiasmatic Nucleus</subject><subject>Suprachiasmatic Nucleus - physiopathology</subject><subject>Time</subject><subject>Treatment</subject><issn>0735-7044</issn><issn>1939-0084</issn><isbn>1433818418</isbn><isbn>9781433818417</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0MFO3DAQBmCrBcEClXiCKlIvHBo69jiOw62sKCBtVQnt3Zq1vUq22Ti1k1b79oTCgsRl5vLNr9HP2DmHSw5YfiMALLTGD2zGK6xyAC0_shMuETXXkusDNoMSi7wEKY_ZSUobAJAgiyN2LKRSoAo9Y8uHejfU24w6l_0MwV1lD76loQldqps-Zdd--Od9lw21z-ZNtOQa6rJ5G-zv15v8_4l3E67pbxPiGTtcU5v8p5d9ypY_bpbzu3zx6_Z-_n2RE0o95FqLAqxYl0R2ZYVwVlZIqLQAJ6zT3qElq0phdTFNZ0kVINacqpIrscJTdvEc28fwZ_RpMNsmWd-21PkwJsMLFFJz5GqiX97RTRhjNz03KaiUqEqs3gJtDClFvzZ9bLYUd4aDeWrd7Fuf6OeXwHG19e4V7pudwNdnQD2ZPu0sxaGxrU92jNF3g1l13nChDRoUCh8BIlaH8Q</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Schnell, Anna</creator><creator>Albrecht, Urs</creator><creator>Sandrelli, Federica</creator><general>American Psychological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5631-7467</orcidid><orcidid>https://orcid.org/0000-0002-0663-8676</orcidid></search><sort><creationdate>20140601</creationdate><title>Rhythm and Mood: Relationships Between the Circadian Clock and Mood-Related Behavior</title><author>Schnell, Anna ; Albrecht, Urs ; Sandrelli, Federica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a348t-88250c2f7aacbc22dc493a36820d2cd8ed3cac672c85672dca6502f1a97162b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Affect</topic><topic>Affective Disorders</topic><topic>Animal</topic><topic>Animal Circadian Rhythms</topic><topic>Animal Models</topic><topic>Animals</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Biogenic Monoamines - metabolism</topic><topic>Chronobiology Disorders - complications</topic><topic>Chronotherapy - methods</topic><topic>Circadian Clocks - genetics</topic><topic>Circadian Clocks - physiology</topic><topic>Human</topic><topic>Humans</topic><topic>Hypothalamic Pituitary Adrenal Axis</topic><topic>Hypothalamo-Hypophyseal System - physiopathology</topic><topic>Models, Biological</topic><topic>Mood Disorders - complications</topic><topic>Mood Disorders - drug therapy</topic><topic>Mood Disorders - genetics</topic><topic>Mood Disorders - metabolism</topic><topic>Mood Disorders - physiopathology</topic><topic>Mood Disorders - therapy</topic><topic>Neurogenesis</topic><topic>Neurogenesis - physiology</topic><topic>Neurotransmission</topic><topic>Olfactory Bulb</topic><topic>Olfactory Bulb - physiopathology</topic><topic>Photoperiod</topic><topic>Pituitary-Adrenal System - physiopathology</topic><topic>Suprachiasmatic Nucleus</topic><topic>Suprachiasmatic Nucleus - physiopathology</topic><topic>Time</topic><topic>Treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schnell, Anna</creatorcontrib><creatorcontrib>Albrecht, Urs</creatorcontrib><creatorcontrib>Sandrelli, Federica</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Access via APA PsycArticles® (ProQuest)</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schnell, Anna</au><au>Albrecht, Urs</au><au>Sandrelli, Federica</au><au>Blumberg, Mark S</au><au>Nelson, Randy J</au><au>Weil, Zachary M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rhythm and Mood: Relationships Between the Circadian Clock and Mood-Related Behavior</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>128</volume><issue>3</issue><spage>326</spage><epage>343</epage><pages>326-343</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><isbn>1433818418</isbn><isbn>9781433818417</isbn><abstract>Mood disorders are multifactorial and heterogeneous diseases caused by the interplay of several genetic and environmental factors. In humans, mood disorders are often accompanied by abnormalities in the organization of the circadian system, which normally synchronizes activities and functions of cells and tissues. Studies on animal models suggest that the basic circadian clock mechanism, which runs in essentially all cells, is implicated in the modulation of biological phenomena regulating affective behaviors. In particular, recent findings highlight the importance of the circadian clock mechanisms in neurological pathways involved in mood, such as monoaminergic neurotransmission, hypothalamus-pituitary-adrenal axis regulation, suprachiasmatic nucleus and olfactory bulb activities, and neurogenesis. Defects at the level of both, the circadian clock mechanism and system, may contribute to the etiology of mood disorders. Modification of the circadian system using chronotherapy appears to be an effective treatment for mood disorders. 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| subjects | Affect Affective Disorders Animal Animal Circadian Rhythms Animal Models Animals Antidepressive Agents - therapeutic use Biogenic Monoamines - metabolism Chronobiology Disorders - complications Chronotherapy - methods Circadian Clocks - genetics Circadian Clocks - physiology Human Humans Hypothalamic Pituitary Adrenal Axis Hypothalamo-Hypophyseal System - physiopathology Models, Biological Mood Disorders - complications Mood Disorders - drug therapy Mood Disorders - genetics Mood Disorders - metabolism Mood Disorders - physiopathology Mood Disorders - therapy Neurogenesis Neurogenesis - physiology Neurotransmission Olfactory Bulb Olfactory Bulb - physiopathology Photoperiod Pituitary-Adrenal System - physiopathology Suprachiasmatic Nucleus Suprachiasmatic Nucleus - physiopathology Time Treatment |
| title | Rhythm and Mood: Relationships Between the Circadian Clock and Mood-Related Behavior |
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