The structure, occurrence and biological activity of ellagitannins: a general review
The present paper deals with the structure, occurrence and biological activity of ellagitannins. Ellagitannins belong to the class of hydrolysable tannins, they are esters of hexahydroxydiphenoic acid and monosaccharide (most commonly glucose). Ellagitannins are slowly hydrolysed in the digestive tr...
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| Veröffentlicht in: | Acta Scientiarum Polonorum. Technologia Alimentaria 2014-07, Vol.13 (3), p.289-299 |
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| container_title | Acta Scientiarum Polonorum. Technologia Alimentaria |
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| creator | Lipińska, Lidia Klewicka, Elżbieta Sójka, Michał |
| description | The present paper deals with the structure, occurrence and biological activity of ellagitannins. Ellagitannins belong to the class of hydrolysable tannins, they are esters of hexahydroxydiphenoic acid and monosaccharide (most commonly glucose). Ellagitannins are slowly hydrolysed in the digestive tract, releasing the ellagic acid molecule. Their chemical structure determines physical and chemical properties and biological activity. Ellagitannins occur naturally in some fruits (pomegranate, strawberry, blackberry, raspberry), nuts (walnuts, almonds), and seeds. They form a diverse group of bioactive polyphenols with anti-inflammatory, anticancer, antioxidant and antimicrobial (antibacterial, antifungal and antiviral) activity. Furthermore, they improve the health of blood vessels. The paper discusses the metabolism and bioavailability of ellagitannins and ellagic acid. Ellagitannins are metabolized in the gastrointestinal tract by intestinal microbiota. They are stable in the stomach and undergo neither hydrolysis to free ellagic acid nor degradation. In turn, ellagic acid can be absorbed in the stomach. This paper shows the role of cancer cell lines in the studies of ellagitannins and ellagic acid metabolism. The biological activity of these compounds is broad and thus the focus is on their antimicrobial, anti-inflammatory and antitumor properties. Ellagitannins exhibit antimicrobial activity against fungi, viruses, and importantly, bacteria, including antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus. |
| doi_str_mv | 10.17306/J.AFS.2014.3.7 |
| format | Article |
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Ellagitannins belong to the class of hydrolysable tannins, they are esters of hexahydroxydiphenoic acid and monosaccharide (most commonly glucose). Ellagitannins are slowly hydrolysed in the digestive tract, releasing the ellagic acid molecule. Their chemical structure determines physical and chemical properties and biological activity. Ellagitannins occur naturally in some fruits (pomegranate, strawberry, blackberry, raspberry), nuts (walnuts, almonds), and seeds. They form a diverse group of bioactive polyphenols with anti-inflammatory, anticancer, antioxidant and antimicrobial (antibacterial, antifungal and antiviral) activity. Furthermore, they improve the health of blood vessels. The paper discusses the metabolism and bioavailability of ellagitannins and ellagic acid. Ellagitannins are metabolized in the gastrointestinal tract by intestinal microbiota. They are stable in the stomach and undergo neither hydrolysis to free ellagic acid nor degradation. In turn, ellagic acid can be absorbed in the stomach. This paper shows the role of cancer cell lines in the studies of ellagitannins and ellagic acid metabolism. The biological activity of these compounds is broad and thus the focus is on their antimicrobial, anti-inflammatory and antitumor properties. 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Technologia Alimentaria</title><addtitle>Acta Sci Pol Technol Aliment</addtitle><description>The present paper deals with the structure, occurrence and biological activity of ellagitannins. Ellagitannins belong to the class of hydrolysable tannins, they are esters of hexahydroxydiphenoic acid and monosaccharide (most commonly glucose). Ellagitannins are slowly hydrolysed in the digestive tract, releasing the ellagic acid molecule. Their chemical structure determines physical and chemical properties and biological activity. Ellagitannins occur naturally in some fruits (pomegranate, strawberry, blackberry, raspberry), nuts (walnuts, almonds), and seeds. They form a diverse group of bioactive polyphenols with anti-inflammatory, anticancer, antioxidant and antimicrobial (antibacterial, antifungal and antiviral) activity. Furthermore, they improve the health of blood vessels. The paper discusses the metabolism and bioavailability of ellagitannins and ellagic acid. Ellagitannins are metabolized in the gastrointestinal tract by intestinal microbiota. They are stable in the stomach and undergo neither hydrolysis to free ellagic acid nor degradation. In turn, ellagic acid can be absorbed in the stomach. This paper shows the role of cancer cell lines in the studies of ellagitannins and ellagic acid metabolism. The biological activity of these compounds is broad and thus the focus is on their antimicrobial, anti-inflammatory and antitumor properties. Ellagitannins exhibit antimicrobial activity against fungi, viruses, and importantly, bacteria, including antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus.</description><subject>Anti-Infective Agents - metabolism</subject><subject>Anti-Inflammatory Agents - metabolism</subject><subject>Antineoplastic Agents - metabolism</subject><subject>Ellagic Acid - chemistry</subject><subject>Ellagic Acid - metabolism</subject><subject>Fruit - chemistry</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Humans</subject><subject>Hydrolyzable Tannins - chemistry</subject><subject>Hydrolyzable Tannins - metabolism</subject><subject>Nuts - chemistry</subject><subject>Polyphenols - chemistry</subject><subject>Polyphenols - metabolism</subject><issn>1644-0730</issn><issn>1898-9594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kLFOwzAURS0EoqUwsyGPDCS1Y8d22KqKAlUlBspsOe5zMUqTYidF_XtSKEz3DeddXR2ErilJqWREjOfpZPaaZoTylKXyBA2pKlRS5AU_7W_BeUJ6boAuYvwgJFeEZudokHGlZMH5EC2X74BjGzrbdgHucGNtFwLUFrCpV7j0TdWsvTUVNrb1O9_uceMwVJVZ-9bUta_jPTZ4DTWEHgqw8_B1ic6cqSJcHXOE3mYPy-lTsnh5fJ5OFollTLVJaRgBroxluVQ5NYaK0q1WtlCMWJeBcLJ0QhrhDOOZUKoURDFgypbcloVgI3T727sNzWcHsdUbH-1hXA1NFzXNWcal5Crv0fEvakMTYwCnt8FvTNhrSvSPSj3XvUp9UKmZlv3HzbG8Kzew-uf_3LFvsIlwLQ</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Lipińska, Lidia</creator><creator>Klewicka, Elżbieta</creator><creator>Sójka, Michał</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>The structure, occurrence and biological activity of ellagitannins: a general review</title><author>Lipińska, Lidia ; Klewicka, Elżbieta ; Sójka, Michał</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-ba30e48ac357851aa16bfddc9830cf2e6f7bf67a6fa342688b6083e38cb4cb963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Anti-Infective Agents - metabolism</topic><topic>Anti-Inflammatory Agents - metabolism</topic><topic>Antineoplastic Agents - metabolism</topic><topic>Ellagic Acid - chemistry</topic><topic>Ellagic Acid - metabolism</topic><topic>Fruit - chemistry</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>Humans</topic><topic>Hydrolyzable Tannins - chemistry</topic><topic>Hydrolyzable Tannins - metabolism</topic><topic>Nuts - chemistry</topic><topic>Polyphenols - chemistry</topic><topic>Polyphenols - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lipińska, Lidia</creatorcontrib><creatorcontrib>Klewicka, Elżbieta</creatorcontrib><creatorcontrib>Sójka, Michał</creatorcontrib><creatorcontrib>Institute of Fermentation Technology and Microbiology, Lodz University of Technology, Poland</creatorcontrib><creatorcontrib>Institute of Chemical Technology of Food, LoLodz University of Technology, Poland</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Scientiarum Polonorum. 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They form a diverse group of bioactive polyphenols with anti-inflammatory, anticancer, antioxidant and antimicrobial (antibacterial, antifungal and antiviral) activity. Furthermore, they improve the health of blood vessels. The paper discusses the metabolism and bioavailability of ellagitannins and ellagic acid. Ellagitannins are metabolized in the gastrointestinal tract by intestinal microbiota. They are stable in the stomach and undergo neither hydrolysis to free ellagic acid nor degradation. In turn, ellagic acid can be absorbed in the stomach. This paper shows the role of cancer cell lines in the studies of ellagitannins and ellagic acid metabolism. The biological activity of these compounds is broad and thus the focus is on their antimicrobial, anti-inflammatory and antitumor properties. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Anti-Infective Agents - metabolism Anti-Inflammatory Agents - metabolism Antineoplastic Agents - metabolism Ellagic Acid - chemistry Ellagic Acid - metabolism Fruit - chemistry Gastrointestinal Tract - metabolism Humans Hydrolyzable Tannins - chemistry Hydrolyzable Tannins - metabolism Nuts - chemistry Polyphenols - chemistry Polyphenols - metabolism |
| title | The structure, occurrence and biological activity of ellagitannins: a general review |
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