Insulin suppresses hepatitis B surface antigen expression in human hepatoma cells

The human hepatoma Hep3B cells contain integrated hepatitis B viral genome and continually secret hepatitis B surface antigen (HBsAg). The production of HBsAg (but not α-fetoprotein) was suppressed by addition of low concentrations (0.1-1 nM) of insulin into serum-free medium. In addition, the suppr...

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Veröffentlicht in:	The Journal of biological chemistry 1989-09, Vol.264 (26), p.15304-15308
Hauptverfasser:	Chou, C K, Su, T S, Chang, C M, Hu, C P, Huang, M Y, Suen, C S, Chou, N W, Ting, L P
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Fetoproteins - genetics Biological and medical sciences Blotting, Northern Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - microbiology Cell Line Cell physiology Fundamental and applied biological sciences. Psychology Genes - drug effects Genes, Viral - drug effects Hepatitis B Surface Antigens - genetics Hepatitis B virus - genetics Hormonal regulation Humans Insulin - pharmacology Insulin-Like Growth Factor I - pharmacology Kinetics Liver Neoplasms - genetics Liver Neoplasms - microbiology Molecular and cellular biology Phosphorylation Proinsulin - pharmacology Receptor, Insulin - metabolism RNA, Messenger - genetics Suppression, Genetic Transcription, Genetic
Online-Zugang:	Volltext
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