Anti-Parkinson effects of a selective alpha2C-adrenoceptor antagonist in the MPTP marmoset model

•Indirect targeting dopaminergic neurotransmission may provide innovative therapeutic potential in Parkinson's disease.•The alpha2C-adrenoceptor antagonist JNJ27063699 mitigates motor deterioration in MPTP monkey model of Parkinson's disease.•The anti-parkinsonian therapeutic dose of JNJ27...

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Veröffentlicht in:	Behavioural brain research 2014-08, Vol.269, p.81-86
Hauptverfasser:	Philippens, Ingrid H.C.H.M., Joosen, Marloes J.A., Ahnaou, Abdellah, Andres, Ignacio, Drinkenburg, Wilhelmus (Pim) H.I.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Administration, Oral Adrenergic alpha-2 Receptor Antagonists - pharmacology Alpha2C-adrenergic Animals Antiparkinson Agents - pharmacology Behavioral psychophysiology Biological and medical sciences Body Temperature - drug effects Body Weight - drug effects Callithrix Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Male Marmoset monkey Motor Activity - drug effects Motor behavior Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Motor Skills - drug effects MPTP Non-human primate Parkinson's disease Parkinsonian Disorders - drug therapy Parkinsonian Disorders - physiopathology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Receptors, Adrenergic, alpha-2 - metabolism Severity of Illness Index Vertebrates: nervous system and sense organs
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