Stimulation of Soluble Guanylate Cyclase Prevents Cigarette Smoke-induced Pulmonary Hypertension and Emphysema

Chronic obstructive pulmonary disease (COPD) is a major cause of death worldwide. No therapy stopping progress of the disease is available. To investigate the role of the soluble guanylate cyclase (sGC)-cGMP axis in development of lung emphysema and pulmonary hypertension (PH) and to test whether th...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2014-06, Vol.189 (11), p.1359-1373
Hauptverfasser:	WEISSMANN, Norbert, LOBO, Borja, STASCH, Johannes-Peter, GHOFRANI, Hossein A, COLL-BONFILL, Núria, FREY, Reiner, SCHERMULY, Ralph T, GARCIA-LUCIO, Jéssica, BLANCO, Isabel, BEDNORZ, Mariola, TURA-CEIDE, Olga, TADELE, Elsa, PICHL, Alexandra, BRANDES, Ralf P, GRIMMINGER, Jan, KLEPETKO, Walter, JAKSCH, Peter, RODRIGUEZ-ROISIN, Robert, SEEGER, Werner, GRIMMINGER, Friedrich, BARBERA, Joan A, PARAJULI, Nirmal, SEIMETZ, Michael, PUIG-PEY, Raquel, FERRER, Elisabet, PEINADO, Víctor I, DOMINGUEZ-FANDOS, David, FYSIKOPOULOS, Athanasios
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Apoptosis Biological and medical sciences Biomarkers - metabolism Blotting, Western Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Disease Models, Animal Down-Regulation Emphysema Emphysema - enzymology Emphysema - prevention & control Ethics Guanylate Cyclase - metabolism Guinea Pigs Humans Hypertension, Pulmonary - enzymology Hypertension, Pulmonary - prevention & control Hypotheses In Vitro Techniques Intensive care medicine Medical sciences Mice Neutrophils Pathogenesis Patients Pneumology Pulmonary Disease, Chronic Obstructive - enzymology Pulmonary Disease, Chronic Obstructive - prevention & control Pulmonary hypertension Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Real-Time Polymerase Chain Reaction Receptors, Cytoplasmic and Nuclear - metabolism Smoking - adverse effects Smoking - metabolism Soluble Guanylyl Cyclase
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